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  1. No Access

    Article

    Serum metabolome analysis by 1H-NMR reveals differences between chronic lymphocytic leukaemia molecular subgroups

    Chronic lymphocytic leukaemia (CLL) is a heterogeneous disease exhibiting variable clinical course and survival rates. Mutational status of the immunoglobulin heavy chain variable regions (IGHVs) of CLL cells ...

    D A MacIntyre, B Jiménez, E Jantus Lewintre, C Reinoso Martín, H Schäfer… in Leukemia (2010)

  2. No Access

    Article

    Engraftment kinetics of human CD34+ cells from cord blood and mobilized peripheral blood co-transplanted into NOD/SCID mice

    We have reported short periods of post transplant neutropenia in human patients co-transplanted with cord blood (CB) and low numbers of haploidentical mobilized peripheral blood (MPB) CD34+ cells. To investiga...

    M Ramírez, C Regidor, I Marugán, J García-Conde, J A Bueren… in Bone Marrow Transplantation (2005)

  3. No Access

    Article

    Bcl-6 mutation status provides clinically valuable information in early-stage B-cell chronic lymphocytic leukemia

    In B-cell chronic lymphocytic leukemia (B-CLL), somatic mutation of IgVH genes defines a subgroup with favorable prognosis, whereas the absence of IgVH mutations is correlated with a worse outcome. Mutations of t...

    E Sarsotti, I Marugan, I Benet, M J Terol, D Sanchez-Izquierdo, M Tormo… in Leukemia (2004)

  4. No Access

    Article

    Mobilization of peripheral blood progenitor cells with a combination of cyclophosphamide, r-metHuSCF and filgrastim in patients with breast cancer previously treated with chemotherapy

    The objective of our study was to determine the effect of adding r-metHuSCF to Filgrastim and cyclophosphamide for mobilization of peripheral blood progenitor cells (PBPC), on collection of CD34+ cells and engraf...

    F Prósper, C Solá, J Hornedo, C Arbona, P Menéndez, A Orfao, A Lluch… in Leukemia (2003)

  5. No Access

    Article

    Allogeneic transplantation of CD34+-selected cells from peripheral blood in patients with myeloid malignancies in early phase: a case control comparison with unmodified peripheral blood transplantation

    An allogeneic transplantation of CD34+-selected cells from peripheral blood (allo-PBT/CD34+) from HLA-identical sibling donors was performed in 50 adult patients with acute myeloid leukemia in first complete remi...

    A Urbano-Ispizua, S Brunet, C Solano, JM Moraleda, M Rovira… in Bone Marrow Transplantation (2001)

  6. No Access

    Article

    Sequential analysis of CD34+ and CD34− cell subsets in peripheral blood and leukapheresis products from breast cancer patients mobilized with SCF plus G-CSF and cyclophosphamide

    Administration of stem cell factor (SCF) has been proven to enhance cytokine-induced mobilization of CD34+ hematopoietic progenitor cells (HPC) into the peripheral blood (PB). The aim of the present study was to ...

    P Menéndez, F Prósper, C Bueno, C Arbona, JF San Miguel, J García-Conde, C Solá… in Leukemia (2001)

  7. No Access

    Article

    Autologous stem cell transplantation for clinically aggressive non-Hodgkin's lymphoma: the role of preparative regimens

    We investigated the impact of the most commonly used preparative regimens on the outcome of 395 patients with diffuse large cell lymphoma (DLCL), consecutively reported to the registry of the Spanish GEL/TAMO....

    A Salar, J Sierra, M Gandarillas, MD Caballero, J Marín… in Bone Marrow Transplantation (2001)

  8. No Access

    Article

    Prognostic significance of the immunocytochemical detection of contaminating tumor cells (CTC) in apheresis products of patients with high-risk breast cancer treated with high-dose chemotherapy and stem cell transplantation

    The aim of this study was to determine whether the detection of CTC in the apheresis product contribute significantly to treatment failure of patients with high-risk breast carcinoma treated with high-dose che...

    C Solano, B Badia, A Lluch, I Marugan, I Benet, C Arbona… in Bone Marrow Transplantation (2001)

  9. No Access

    Article

    Chromosomal abnormalities in women with breast cancer after autologous stem cell transplantation are infrequent and may not predict development of therapy-related leukemia or myelodysplastic syndrome

    We determined prospectively the incidence of chromosomal abnormalities in patients with high-risk breast cancer (HRBC) after high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT), and c...

    JA Martínez-Climent, AM Comes, E Vizcarra, I Benet, C Arbona… in Bone Marrow Transplantation (2000)

  10. Article

    Mutational analysis of BRCA1 and BRCA2 genes in Spanish women with early-onset breast cancer

    JI Martínez-Ferrandis, A Vega, P Marín-Garcia, F Barros… in Breast Cancer Research (2000)

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  11. No Access

    Article

    Chronic graft-versus-host disease after allogeneic peripheral blood progenitor cell or bone marrow transplantation from matched related donors. A case-control study

    We retrospectively compared the incidence and clinical characteristics of cGVHD in 37 allo-PBT recipients transplanted between July 1994 and October 1996 and 37 historical control allo-BMT recipients in a case...

    C Solano, C Martinez, S Brunet, JF Tomás, A Urbano-Ispizua… in Bone Marrow Transplantation (1998)

  12. No Access

    Article

    Allogeneic transplantation of selected CD34+ cells from peripheral blood: experience of 62 cases using immunoadsorption or immunomagnetic technique

    The objective of this study was to analyze CD34+ cell recovery and T cell depletion (TCD) achieved in CD34+ cell grafts using either immunoadsorption or immunomagnetic methods applied to leukapheresis products fr...

    A Urbano-Ispizua, C Solano, S Brunet, J de la Rubia… in Bone Marrow Transplantation (1998)

  13. No Access

    Article

    Maintenance treatment with interferon alpha-2b in multiple myeloma: a prospective randomized study from PETHEMA (Program for the Study and Treatment of Hematological Malignancies, Spanish Society of Hematology)

    The objectives of the present study were to investigate whether interferon alpha (IFN) maintenance could prolong response duration and survival in patients with multiple myeloma (MM) in objective response and ...

    J Bladé, JF San Miguel, ML Escudero, M Fontanillas, J Besalduch, S Gardella… in Leukemia (1998)

  14. No Access

    Article

    Cytogenetic response induced by interferon alpha in the myeloproliferative disorder with eosinophilia, T cell lymphoma and the chromosomal translocation t(8;13)(p11;q12)

    JA Martinez-Climent, E Vizcarra, I Benet, I Marugan, MJ Terol, C Solano… in Leukemia (1998)

  15. No Access

    Chapter and Conference Paper

    Treatment of High-Risk Acute Lymphoblastic Leukemia. Preliminary Results of the Protocol PETHEMA ALL-93

    Objective. To analyze the results of a multicenter prospective randomized protocol, PETHEMA ALL-93, for high-risk acute lymphoblastic leukemia (HRALL).

    J. M. Ribera, J. J. Ortega, A. Oriol, M. Fontanillas, J. Maldonado… in Acute Leukemias VII (1998)

  16. No Access

    Article

    Autologous stem cell transplantation for poor prognosis Hodgkin’s disease in first complete remission: a retrospective study from the Spanish GEL-TAMO cooperative group

    Although more than 50% of Hodgkin’s disease patients are cured with conventional chemotherapy, many will relapse and eventually die from their disease. Many efforts have been made to identify poor prognostic f...

    A Sureda, R Mataix, F Hernández-Navarro, I Jarque… in Bone Marrow Transplantation (1997)

  17. No Access

    Article

    Value of CA 15.3 in breast cancer and comparison with CEA and TPA: A study of specificity in disease-free follow-up patients and sensitivity in patients at diagnosis of the first metastasis

    The specificity and sensitivity of a tumor marker (TM) are important in establishing its potential clinical utility for a specific type of neoplasm. CA 15.3 is a TM specific for breast cancer; it is defined by...

    E. Vizcarra, A. Lluch, R. Cibrián, F. Jarque… in Breast Cancer Research and Treatment (1996)

  18. No Access

    Article

    Frozen vs. nonfrozen bone marrow for autologous transplantation in lymphomas: A report from the Spanish GEL/TAMO Cooperative Group

    To investigate the impact of frozen and nonfrozen bone marrow on engraftment kinetics and disease outcome, 94 patients with non-Hodgkin's lymphoma (NHL) autografted with frozen marrow (F group) were retrospect...

    J. Sierra, E. Conde, A. Iriondo, S. Brunet, J. Marín… in Annals of Hematology (1993)

  19. No Access

    Article

    A randomized multicentric study comparing alternating combination chemotherapy (VCMP/VBAP) and melphalan-prednisone in multiple myeloma

    Between January 1985 and December 1988, 386 patients with multiple myeloma were randomized to receive either MP or combination chemotherapy based on alternating cycles of VCMP and VBAP. The major prognostic pa...

    J. Bladé, J. San Miguel, A. Alcalá, J. Maldonado, J. García-Conde, M. J. Moro… in Blut (1990)

  20. No Access

    Article

    Abstracts

    A. Gulbis, F. Dunham, M. Deltenre, A. Burette, M. de Reuck, Ph. Drabs… in Acta Endoscopica (1984)