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Article
Open AccessImmunoscore and Immunoprofiling in cancer: an update from the melanoma and immunotherapy bridge 2015
The fifth “Melanoma Bridge Meeting” took place in Naples, December 1–5th, 2015. The main topics discussed at this meeting were: Molecular and Immuno advances, Immunotherapies and Combination Therapies, Tumor M...
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Article
Open AccessS47. Tumour infiltrating lymphocytes - a predictive marker?
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Article
Immune infiltration in human tumors: a prognostic factor that should not be ignored
The natural history of a tumor includes phases of ‘in situ’ growth, invasion, extravasation and metastasis. During these phases, tumor cells interact with their microenvironment and are influenced by signals comi...
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Chapter and Conference Paper
Glucocorticoid-Inducible Genes That Regulate T-Cell Function
Upon antigenic challenge, the immune system must detect and respond to subtle perturbations in local microenvironments. While many important transactions entail cell-to-cell contact, coordination between multi...
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Chapter
Soluble FcγR, a biological perspective
Soluble FcγR (sFcγR) were discovered in supernatants of cells of the immune system during the 1970s, and called immunoglobulin G-binding factors. Twenty years later, although the structure and mechanisms of ge...
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Chapter
Soluble CD16/FcγRIII Induces Maturation of Dendritic Cells and Production of Several Cytokines Including IL-12
FcγRIII (CD16), a low affinity FcR which binds IgG-containing immune-complexes, exists under membrane-associated forms and under a soluble form (sFcγRIII). The latter, present in biological fluids (serum, sali...