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  1. No Access

    Article

    Incorporation of 5-Iodo-2′-deoxyuridine into the Deoxyribonucleic Acid of Vaccinia Virus

    THE in vitro development of animal viruses containing deoxyribonucleic acid, such as vaccinia or herpes simplex, is inhibited by the thymidine analogue 5-iodo-2′-deoxyuridine (IUdR), whereas RNA-containing viruse...

    WILLIAM H. PRUSOFF, Y. S. BAKHLE, J. F. MCCREA in Nature (1963)

  2. No Access

    Article

    Release of Deoxyribonucleic Acid from Vaccinia Virus by 2-Mercaptoethanol and Pronase

    IN an earlier report the isolation of a single-stranded DNA from highly purified vaccinia virus was described1. The DNA was extracted under mild conditions with water-saturated phenol and deoxycholate, according ...

    C. J. PFAU, J. F. McCREA in Nature (1962)

  3. No Access

    Article

    Use of Potassium Tartrate for Equilibrium Density-gradient Centrifugation of Animal Viruses

    DENSITY-GRADIENT centrifugation of both the velocity and equilibrium types has been applied for separating and purifying plant viruses such as tobacco mosaic and potato yellows1, and also very recently to animal ...

    J. F. McCREA, RICHARD S. EPSTEIN, WILLIAM H. BARRY in Nature (1961)

  4. No Access

    Article

    Effect of Concentrated Urea Solutions on the Infectivity and Hæmagglutinin of Vaccinia Virus

    DURING preliminary experiments attempting to extract deoxyribonucleic acid from vaccinia virus by various physical and chemical means, we incidentally observed that after exposure to 8 M urea the infectious prope...

    J. F. McCREA, JEAN O'LOUGHLIN in Nature (1959)

  5. No Access

    Article

    Turbidity-reducing Activity of Influenza Virus and Receptor-destroying Enzyme on Sheep Submandibular Mucoid

    A CHARACTERISTIC turbidity develops when polymerized hyaluronic acid is mixed with acidified horse serum; this turbidity, and its destruction by prior incubation with hyaluronidase, is the basis of the turbidi...

    J. F. McCREA in Nature (1953)

  6. No Access

    Article

    Mucin as Substrate of Enzyme Action by Viruses of the Mumps Influenza Group

    In previous work from this laboratory it has been found that the action of influenza viruses on red cells can be paralleled in almost complete detail by an enzyme produced by V. cholerce1 (Stone, 1947). In the co...

    F. M. BURNET, J. F. MCCREA, S. G. ANDERSON in Nature (1947)