-
Article
Open AccessBiomarker alterations associated with distinct patterns of metastatic spread in colorectal cancer
Metastatic spread is the most important life-threatening feature of colorectal cancer and is supposed to be mainly driven by alterations in different carcinogenic pathways. The present study compared mutation ...
-
Article
Open AccessCritical comparison of methods for fault diagnosis in metabolomics data
Platforms like metabolomics provide an unprecedented view on the chemical versatility in biomedical samples. Many diseases reflect themselves as perturbations in specific metabolite combinations. Multivariate ...
-
Article
Cancer of the ovary, fallopian tube, and peritoneum: a population-based comparison of the prognostic factors and outcomes
The objective was to compare the prognostic factors and outcomes among primary ovarian cancer (OC), fallopian tube cancer (FC), and peritoneal cancer (PC) patients in a population-based setting.
-
Article
Trends in surgery and outcomes of squamous cell vulvar cancer patients over a 16-year period (1998–2013): a population-based analysis
The objective was to identify trends in surgery and the outcomes of squamous cell vulvar cancer in a population-based setting.
-
Article
Open AccessData quality issues impede comparability of hospital treatment delay performance indicators
To assess the comparability of five performance indicator scores for treatment delay among patients diagnosed with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary in...
-
Article
Klassifikation der Endometriose
Endometriose ist eine chronische Erkrankung, die etwa 10 % der Frauen in der reproduktiven Phase ihres Lebens betrifft und die durch rezidivierende Unterbauchschmerzen sowie die Beeinträchtigung der Fertilität...
-
Article
Study of compaction and sintering of nanosized oxide powders by in situ electrical measurements and dilatometry: Nano CeO2—case study
Densification and sintering of CeO2 nanoparticles and their electrical properties were simultaneously studied as a function of temperature in controlled atmosphere using a modified dilatometer. CeO2 nanoparticles...
-
Article
Extant diversity of bryophytes emerged from successive post-Mesozoic diversification bursts
Unraveling the macroevolutionary history of bryophytes, which arose soon after the origin of land plants but exhibit substantially lower species richness than the more recently derived angiosperms, has been ch...
-
Article
L-type calcium channels in the auditory system
The voltage-activated L-type calcium channels Cav1.2 and Cav1.3 mediate Ca2+ influx into neurons at the soma or at dendrites, whereas they are not observed at the presynapse. Surprisingly, in the inner ear, Cav1....
-
Article
Open AccessMonitoring guideline adherence in the management of acute coronary syndrome in hospitals: design of a multicentre study
Increasing guideline adherence in the management of acute coronary syndrome (ACS) in hospitals potentially reduces heart failure and mortality. Therefore, an expert panel identified three guideline recommendat...
-
Chapter
Einführung: Wirkungen und Stoffwechsel der praxisrelevanten Hormongruppen
Um Signale im Körper generieren, weiterleiten und empfangen zu können, stehen 3 Systeme zur Verfügung: das Nervensystem, das Immunsystem und das endokrine System. Während die ortsständigen Organe des endokrine...
-
Article
Ungewöhnliche Pneumonie bei zwei immunkompetenten jungen Männern
-
Article
Open AccessSurgical treatment of early stage breast cancer in elderly: an international comparison
Over 40% of breast cancer patients are diagnosed above the age of 65. Treatment of these elderly patients will probably vary over countries. The aim of this study was to make an international comparison (sever...
-
Article
Stellenwert von Lymphknotendissektionen
-
Article
Open AccessPyruvate: immunonutritional effects on neutrophil intracellular amino or alpha-keto acid profiles and reactive oxygen species production
For the first time the immunonutritional role of pyruvate on neutrophils (PMN), free α-keto and amino acid profiles, important reactive oxygen species (ROS) produced [superoxide anion (O2
-
Article
Mammographiescreening
-
Article
Mammographiescreening
Bundesweit begann das deutsche Mammographie-Screeningprogramm (DMS) im Mai 2005, in Bayern (B) durchschnittlich im Februar 2007, in Thüringen (T) im Mai 2007 und im Februar 2009. Zwischen 2003 und 2006 wurde i...
-
Article
Effects of α-ketoglutarate on neutrophil intracellular amino and α-keto acid profiles and ROS production
The aim of this study was to determine the effects of α-ketoglutarate on neutrophil (PMN), free α-keto and amino-acid profiles as well as important reactive oxygen species (ROS) produced [superoxide anion (O2 ...
-
Article
Major upper extremity replantations
The usual mechanism of a major amputation creates a mutilating injury. Although survival rate is high, the functional results are guarded [1, 2]. The aim of this study is to review our experience with major up...
-
Article
Ergebnisse der interdisziplinären onkologischen Versorgung
Heutige „Change“-Aktivitäten in der Onkologie basieren nicht selten auf Meinungen. Sie sind vom Zeitgeist getragen und kopieren den Wettbewerb bis hin zur Businessterminologie. Die Versorgungsergebnisse der kr...
