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  1. No Access

    Chapter

    Regulation and Dysregulation of Glutamate Transporters

    Glutamate is the primary excitatory neurotransmitter in the central nervous system. During synaptic activity, glutamate is released into the synaptic cleft and binds to glutamate receptors on the pre- and post...

    R. Sattler, J. D. Rothstein in Neurotransmitter Transporters (2006)

  2. No Access

    Chapter

    Amyotrophic Lateral Sclerosis

    Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurological disorder that results from loss of motor neurons. Many hypotheses have been put forward, including the involvement of environmental facto...

    M. Jackson, J. D. Rothstein in CNS Neuroprotection (2002)

  3. No Access

    Article

    The expression of glutamate transporter GLT-1 in the rat cerebral cortex is down-regulated by the antipsychotic drug clozapine

    We show here that clozapine, a beneficial antipsychotic, down-regulates the expression of the glutamate transporter GLT-1 in the rat cerebral cortex, thereby reducing glutamate transport and raising extracellu...

    M Melone, L Vitellaro-Zuccarello, A Vallejo-Illarramendi… in Molecular Psychiatry (2001)

  4. No Access

    Chapter

    Glutamate Transporter Dysfunction and Neuronal Death

    This chapter summarizes the normal function of the four major glutamate transporters in the mammalian central nervous system (CNS), as well as their structure, distribution, and cellular localization. We will ...

    R. Ganel, J. D. Rothstein in Ionotropic Glutamate Receptors in the CNS (1999)

  5. No Access

    Article

    Differential expression of three glutamate transporter subtypes in the rat retina

    The immunocytochemical distribution of the three excitatory amino acid transporter subtypes GLT-1, GLAST-1 and EAAC-1 was studied in the rat retina using antibodies raised against synthetic peptides correspond...

    T. Rauen, J. D. Rothstein, H. Wässle in Cell and Tissue Research (1996)

  6. No Access

    Chapter

    Brainstem Motoneuron Cell Groups that die in Amyotrophic Lateral Sclerosis are Rich in the GLT-1 Glutamate Transporter

    Several studies have suggested that excessive Ca2+ influx into cells may underlie the selective destruction of motoneurons observed in the sporadic form of Amyotrophic Lateral Sclerosis (ALS)1–4. Consistent with ...

    Loreta Medina, Griselle Figueredo-Cardenas, J. D. Rothstein… in Neurodegenerative Diseases (1996)