-
Chapter
Arenavirus Diversity and Evolution: Quasispecies In Vivo
Arenaviruses exist as viral quasispecies due to the high mutation rates of the low-fidelity viral RNA-dependent RNA polymerase (RdRp). This genomic heterogeneity is advantageous to the population, allowing for...
-
Chapter
Arenaviruses: Genomic RNAs, Transcription, and Replication
The arenavirus genome comprises two single-stranded RNA molecules of negative polarity, designated L and S, that contain essentially nonoverlap** sequence information (for extensively referenced reviews see Buc...
-
Chapter
Reverse Genetics of Arenaviruses
Arenaviruses merit significant attention both as experimental models to study acute and persistent infections and as clinically important human pathogens, including hemorrhagic fever agents such as Lassa virus.
-
Chapter
Contribution of LCMV Towards Deciphering Biology of Quasispecies In Vivo
Arenaviruses have often been viewed as relatively stable genetically with amino acid sequence homologies of 90%–95% among different strains of lymphocytic choriomeningitis virus (LCMV) and of 44%–63% for homol...
-
Chapter
Effects of Aging on the Human Nervous System
Elderly patients are known to represent a major proportion of problems affecting the central nervous system (CNS) and consequently make up a significant percentage of patients requiring elective or emergency s...
-
Article
Critical threshold cerebral hypoperfusion causes Alzheimer’s disease?
After nearly a century of inquiry, the cause of Alzheimer’s disease (AD) remains to be found. In this review, basic and clinical evidence is presented that assembles and hypothetically explains most of the ke...
-
Chapter
Cytochrome Oxidase
Cytochrome oxidase has been used in the past as a marker of neuronal activity. We propose that cytochrome oxidase may also serve as a useful marker for predicting potential neurodegeneration, particularly foll...
-
Chapter
Progressive Neurodegeneration in Rat Brain after Chronic 3-VO or 2-VO
Progressive neurodegeneration in the aging population is commonly associated with human dementia, including Alzheimer’s disease (AD) (Rose and Hennebery, 1994)
-
Chapter
Molecular Biology of Borna Disease Virus
Originally described in the early nineteenth century as a fatal encephalitis in horses, Borna disease (BD) has become an extraordinarily valuable model for the study of both molecular mechanisms and biological...
-
Article
Supraspinal fiber outgrowth and apparent synaptic remodelling across transected-reconstructed feline spinal cord
Following complete transection of the spinal cord at T 9, 12 cats were separated into two groups:
-
Article
The no-reflow phenomenon is a post-mortem artifact
Post-ischemic reperfusion impairment, (“no-reflow phenomenon”), was studied in rats subjected to 8–30 minutes of global brain ischemia. During ischemia, rapid and complete loss of cerebral blood flow, EEG and31P-...
-
Chapter
RNA Virus Populations as Quasispecies
This chapter discusses the high mutation frequencies and rapid evolution potential of RNA viruses. The concepts discussed are applicable to all “ordinary” RNA viruses (riboviruses), viroids and satellite RNAs;...
-
Article
Dimethly sulphoxide lowers ICP after closed head trauma
Ten patients with closed head trauma and elevated intracranial pressure (ICP) ranging from 40–127 mm Hg were treated with intravenous dimethyl sulphoxide (DMSO) every 6 h for 1–10 days. Four patients received ...
-
Article
Collagen-omental graft in experimental spinal cord transection
Spinal cord transection was induced in 3 groups of cats. The gap was surgically reconstructed using a collagen matrix bridge (Group COL), collagen matrix + pedicled omentum graft (Group COM), or gelfoam (Group...
-
Chapter and Conference Paper
Increased Blood Flow Augments CNS Axon Regeneration
Aging is known to increase the potential for progressive central nervous system (CNS) deterioration. Often, age-related loss of motor and cognitive function can be linked to reduced CNS blood flow (Grubb et al., ...
-
Chapter
Can transected spinal cord axons be bribed into regeneration?
Researchers in the field of spinal cord trauma generally recognize a number of factors that can influence the potential regrowth of transected CNS nerve fibres. These factors have been discussed in several rev...
-
Chapter
The Tilt Formula for CNS Lesions: Effects of Dimethyl Sulfoxide
There are presently no criteria to grade CNS lesions for the purpose of assessing the value of an experimental or clinical therapy. We have devised a simple formula to score CNS injuries that allows evaluation...
-
Chapter
Neurophysiology of Movement Disorders
The relation of the cortex, cerebellum, and basal ganglia and their participation in movement disorders is presented. Studies have shown that lesions to the cortex will produce contralateral paralysis while da...
-
Article
A methodological approach to rapid and sensitive monoamine histofluorescence using a modified glyoxylic acid technique: The SPG method
A modified approach of the glyoxylic acid (GA) condensation reaction for the visualization of biogenic amines in tissue is described.
-
Chapter and Conference Paper
Ultrastructural Studies on Formation of Edema and Its Treatment Following Experimental Brain Infarction in Monkeys
A transorbital surgical approach was used in 20 rhesus monkeys to expose and occlude the left middle cerebral artery (MCA) 5 millimeters lateral to the supraclinoid portion of the internal carotid artery. This...
