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  1. No Access

    Article

    Modulation of melanoma-associated antigens by monoclonal antibodies as visualized by radioimmunoelectron microscopy and radioantibody binding assay

    There is a wealth of information about monoclonal antibody (MAb) specificity and function on fixed tissues, yet little is known about formation and release of antigen-antibody complexes and their functional be...

    W. Tilgen, S. Matzku, I. Kaufmann, M. Engstner… in Archives of Dermatological Research (1987)

  2. No Access

    Chapter

    Immunologische Aspekte maligner Melanome

    Klinische und histologische Beobachtungen führten zu der Vorstellung, daß immunologische Vorgänge bei der Melanomerkrankung eine wichtige Rolle spielen.

    E.-B. Bröcker, J. Brüggen, L. Suter, C. Sorg, E. Macher in Malignes Melanom (1986)

  3. No Access

    Article

    Selective toxicity of neocarzinostatin-monoclonal antibody conjugates to the antigen-bearing human melanoma cell line in vitro

    Monoclonal antibodies (IgG1) against high molecular weight antigen A-1-43 on human melanoma cell line A-375 were successfully linked to the anti-tumour protein neocarzinostatin (NCS) using the heterobifunctional ...

    G. Lüders, W. Köhnlein, C. Sorg, J. Brüggen in Cancer Immunology, Immunotherapy (1985)

  4. No Access

    Chapter

    Cellular and Molecular Parameters of Tumor Progression in Human Malignant Melanoma

    Human malignant melanoma is a spontaneous tumor, which progresses from the initial premalignant lesion to highly metastatic forms. Tumor progression seems to be a complex multistage process, during which sever...

    J. Brüggen, E.-B. Bröcker, L. Suter, K. Redmann… in Cutaneous Melanoma and Precursor Lesions (1984)

  5. No Access

    Article

    Detection of phenotypic differences on human malignant melanoma lines and their variant sublines with monoclonal antibodies

    The hybridoma technique was used to generate monoclonal antibodies against a wide spectrum of melanoma-associated surface antigens. Mice were immunized against the human melanoma lines Mel A-375, SK Mel-25, an...

    J. Brüggen, C. Sorg in Cancer Immunology, Immunotherapy (1983)

  6. No Access

    Article

    Tumor production in the nude mouse, fibrinolytic activity and cross-reactivity with antimelanoma sera of various human tumor cell lines

    It has been reported previously that antisera produced in non human primates against many cultured human melanoma lines recognize tumorassociated antigens on the melanoma cells. The reactivity correlated with ...

    J. Brüggen, J. Fogh, C. Sorg in Journal of Cancer Research and Clinical Oncology (1981)

  7. No Access

    Chapter and Conference Paper

    Expression of Tumor-Associated Surface Antigens and Their Correlation to Parameters of Malignancy in Human Malignant Melanoma

    While there is wide agreement, that tumor cells express different sets of structural elements on their cell surface compared to their normal counterparts, the question is still unsettled, whether the different...

    C. Sorg, J. Brüggen, V. Klimetzek, E. Macher in Immunodiagnosis and Immunotherapy of Malig… (1979)

  8. No Access

    Article

    Membrane associated antigens of human malignant melanoma V: Serological ty** of cell lines using antisera from nonhuman primates

    Antisera against various melanoma cell lines were raised in nonhuman primates (Cercopithecus aethiop.). After exhaustive absorption with AB Rh + red blood cells and pooled platelets from about 200 donors the sera...

    J. Brüggen, C. Sorg, E. Macher in Cancer Immunology, Immunotherapy (1978)

  9. No Access

    Article

    Membrane-associated antigens of human malignant melanoma IV: Changes in expression of antigens on cultured melanoma cells

    Established melanoma cell lines were cultured for one passage (approximately 1 week) in different lots of fetal calf and new born calf sera and then tested against a panel of previously positively reacting ser...

    C. Sorg, J. Brüggen, Edelgard Seibert, E. Macher in Cancer Immunology, Immunotherapy (1978)

  10. No Access

    Article

    Zur Glazialgeologie der chilenischen Anden

    J. Brüggen in Geologische Rundschau (1929)