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Cellular and Molecular Parameters of Tumor Progression in Human Malignant Melanoma

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Cutaneous Melanoma and Precursor Lesions

Part of the book series: Developments in Oncology ((DION,volume 25))

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Abstract

Human malignant melanoma is a spontaneous tumor, which progresses from the initial premalignant lesion to highly metastatic forms. Tumor progression seems to be a complex multistage process, during which several distinct properties have to be aquired by the tumor cells either sequentially or in parallel (1,2). Properties of prime importance are believed to be invasiveness, neovascularization, resistance to rejection mechanism and adaptation to and growth in different organs or tissues (2). There is growing evidence that a certain stage of malignancy is not fixed, but phenotypically instable and may move to stages of higher, respectively lower malignancy depending on exogeneous and endogeneous signals (3-5). The highly malignant cells differ from the premalignant precursors in the expression of different biochemical biological proper-ties, which also include the cell surface (6,7).

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Authors
  1. J. Brüggen
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  2. E.-B. Bröcker
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  3. L. Suter
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  4. K. Redmann
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  5. C. Sorg
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Editor information

Editors and Affiliations

  1. Department of Pathology, University Medical Center, Leiden, The Netherlands

    Dirk J. Ruiter MD

  2. Department of Pathology, Faculty of Medicine, University of Leiden, Wassenaarseweg 62, 2333 AL, Leiden, The Netherlands

    Dirk J. Ruiter MD

  3. Department of Surgical Oncology, University Medical Center, Leiden, The Netherlands

    Kees Welvaart MD

  4. Department of Surgery, University Hospital, Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands

    Kees Welvaart MD

  5. Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA

    Soldano Ferrone MD

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© 1984 Martinus Nijhoff Publishers, Dordrecht

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Brüggen, J., Bröcker, EB., Suter, L., Redmann, K., Sorg, C. (1984). Cellular and Molecular Parameters of Tumor Progression in Human Malignant Melanoma. In: Ruiter, D.J., Welvaart, K., Ferrone, S. (eds) Cutaneous Melanoma and Precursor Lesions. Developments in Oncology, vol 25. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6057-2_4

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  • DOI: https://doi.org/10.1007/978-94-009-6057-2_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6059-6

  • Online ISBN: 978-94-009-6057-2

  • eBook Packages: Springer Book Archive

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