53 Result(s)

Article

Genetic variability in response to infection: malaria and after

Recent studies have shown that the relatively short period of exposure of human populations to malaria has left in its wake a wide range of genetic diversity. And there is growing evidence that other infectiou...

D J Weatherall, J B Clegg in Genes & Immunity (2002)

Article

Minisatellite mutational processes reduce F_st estimates

We have used a new method for binning minisatellite alleles (semi-automated allele aggregation) and report the extent of population diversity detectable by eleven minisatellite loci in 2689 individuals from 1...

J. Flint, J. Bond, D. C. Rees, A. J. Boyce, J. M. Roberts-Thomson… in Human Genetics (1999)

Article

Rugged Thin Film Diode Liquid Crystal Switches Based on Amorphous Sin_x:H

Amorphous SiNx:H thin film diodes (TFDs) can be used for pixel addressing in active matrix liquid crystal displays. They depend on the application of high electric fields to switch from the ‘off’ to the ‘on’ s...

B. Mc Garvey, J. B. Clegg, S. C. Deane, J. N. Sandoe… in MRS Online Proceedings Library (1997)

Article

A gene tree for β-globin sequences from melanesia

We have analyzed allelic sequence variation in sixty-one 3-kb β-globin sequences from the Melanesian population of Vanuatu to demonstrate the value of (1) turning to the autosomal nuclear genome for studies on...

R. M. Harding, S. M. Fullerton, R. C. Griffiths… in Journal of Molecular Evolution (1997)

Article

High incidence of malaria in α-thalassaemic children

THE α⁺-thalassaemias are the commonest known human genetic disorders, affecting up to 80 per cent of some populations¹. Although there is good evidence from both epidemiological^2,3 and clinical⁴ studies that thes...

T. N. Williams, K. Maitland, S. Bennett, M. Ganczakowski, T. E. A. Peto… in Nature (1996)

Article

Thalassemia — a global public health problem

The thalassemias and related genetic diseases pose public health problems for many countries in the next millennium. Will it be possible to apply research results to their control and management on the scale r...

D.J. Weatherall, J.B. Clegg in Nature Medicine (1996)

Article

Preface

Alessandro Giacomello, G. J. Peters, Staffan Eriksson… in Pharmacy World and Science (1995)

Article

DNA from ancient Easter Islanders

Erika Hagelberg, Silvia Quevedo, Daniel Turbon, J. B. Clegg in Nature (1994)

Article

Demographic reductions and genetic bottlenecks in humans: minisatellite allele distributions in oceania

Polynesians have lower heterozygosities at minisatellite VNTR (Variable Number of Tandem Repeat) loci than have Melanesians; this has been taken as evidence of population-size bottlenecks during the colonisati...

J. J. Martinson, R. M. Harding, G. Philippon, F. Flye Sainte-Marie… in Human Genetics (1993)

Article

Why are some genetic diseases common?

Various processes (selection, mutation, migration and genetic dirft) are known to determine the frequency of genetic disease in human populations, but so far it has proved almost impossible to decide to what e...

J. Flint, Rosalind M. Harding, J. B. Clegg, A. J. Boyce in Human Genetics (1993)

Article

Comparison of theα-globin gene cluster structure in Perissodactyla

To investigate molecular evolution in a mammalian order with a comprehensive fossil record, we have constructedα-globin-like gene cluster maps for members of the order Perissodactyla. Although the arrangement of ...

J. Flint, O. A. Ryder, J. B. Clegg in Journal of Molecular Evolution (1990)

Article

Population bottlenecks in Polynesia revealed by minisatellites

Tandem-repetitive highly variable loci in the human genome (minisatellites) have been used in gene map** and as DNA “fingerprints”, but they have not yet found much application in population genetics. We hav...

J. Flint, A. J. Boyce, J. J. Martinson, J. B. Clegg in Human Genetics (1989)

Article

Electrically active defects in shallow pre-amorphisedp ⁺ n junctions in silicon

An examination of shallow pre-amorphisedp ⁺ n junctions in silicon has revealed three distinct defect related phenomena determined largely by the annealing temperat...

S. D. Brotherton, J. R. Ayres, J. B. Clegg, J. P. Gowers in Journal of Electronic Materials (1989)

Article

Electrical Characterisation of Shallow Pre-Amorphised p⁺n Junctions in Silicon

An examination of Si⁺ pre-amorphised p⁺n structures as a function of Si⁺ implantation energy and solid phase epitaxial regrowth temperature has revealed three different classes of defect all of which may influenc...

S.D. Brotherton, J.R. Ayres, J.B. Clegg, B.J. Goldsmith in MRS Online Proceedings Library (1987)

Article

Beryllium diffusion across GaAs/(Al, Ga)As heterojunctions and GaAs/AlAs superlattices during MBE growth

Beryllium diffusion during MBE growth of (Al, Ga)As layers, (Al, Ga)As/GaAs heterojunctions and GaAs/AlAs superlattices has been studied by electrochemical C-V and secondary ion mass spectrometry (SIMS) concen...

R. L. S. Devine, C. T. Foxon, B. A. Joyce, J. B. Clegg, J. P. Gowers in Applied Physics A (1987)

Article

Can the product of the θ gene be a real globin?

A new member (θ1, or ψα) of the α-globin gene family has recently been identified in a number of species^1–5. In higher primates the θ1 gene has all the structural features apparently necessary for expression, an...

J. B. Clegg in Nature (1987)

Article

Silicon migration during MBE growth of doped (A1, Ga)As films

Silicon migration during MBE growth of (Al, Ga)As and (Al, Ga)As/GaAs or AlAs/GaAs superlattices has been studied by electrochemical C-V and secondary ion mass spectrometry (SIMS) concentration-depth profiling...

Luisa Gonzalez, J. B. Clegg, D. Hilton, J. P. Gowers, C. T. Foxon… in Applied Physics A (1986)