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Article
Open AccessComputer-assisted femoral head reduction osteotomies: an approach for anatomic reconstruction of severely deformed Legg-Calvé-Perthes hips. A pilot study of six patients
Legg–Calvé–Perthes (LCP) is a common orthopedic childhood disease that causes a deformity of the femoral head and to an adaptive deformity of the acetabulum. The altered joint biomechanics can result in early ...
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Article
The magnetic two-centre problem: Nuclear fusion catalyzed by ultrastrong fields?
Employing the finite-element method (FEM), accurate potential energy curves for the ground state of the homonuclear system consisting of two (static) protons and one electron within a parallel homogeneous magn...
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Article
Bortezomib in relapsed multiple myeloma: response rates and duration of response are independent of a chromosome 13q-deletion
Studies of bortezomib in patients with relapsed multiple myeloma (MM) suggested that bortezomib may be active even in the presence of adverse prognostic factors. We therefore evaluated 62 patients with relapse...
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Article
Both IGH translocations and chromosome 13q deletions are early events in monoclonal gammopathy of undetermined significance and do not evolve during transition to multiple myeloma
Molecular and genetic events associated with the transition from monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM) are still poorly characterized. We investigated serial bone m...
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Chapter and Conference Paper
Experimental comparison of DNA libraries using microelectronic arrays
The problem of designing sets of modular DNA sequences (“words”) which hybridize in a predefined way is fundamental to many molecular biology procedures (e.q. multiplex PCR [1], readout of bar codes [3], const...
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Article
Diffuse large B-cell lymphomas with plasmablastic/plasmacytoid features are associated with TP53 deletions and poor clinical outcome
To define reproducible criteria for subgroups of diffuse large B-cell lymphomas (DLBCL), including lymphomas with plasmablastic/plasmacytoid features (PB/PC-Fs), we investigated 66 DLBCL; the samples were cate...
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Article
Simultaneous occurrence of chronic myeloid leukemia and multiple myeloma: Evaluation by FISH analysis and in vitro expansion of bone marrow cells
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Chapter
Self-Adaptive Finite Element Techniques for Stable Bound Matter-Antimatter Systems in Crossed Electric and Magnetic Fields
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Article
Absence of clonal chromosomal relationship between concomitant B-CLL and multiple myeloma – a report on two cases
B-cell chronic lymphocytic leukemia (B-CLL) and multiple myeloma (MM) are chronic B-cell malignancies that represent different stages of B-cell maturation. Occasionally, both diseases are present in the same ...
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Article
Advances in the biology and therapeutic management of multiple myeloma
During the past decade, new developments have increased our understanding of the biological features of multiple myeloma (MM), and novel therapeutic approaches have improved the outcome and quality of life. T...
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Article
Deletion of chromosome 13q14 detected by fluorescence in situ hybridization has prognostic impact on survival after high-dose therapy in patients with multiple myeloma
Interphase cytogenetic analysis of chromosome 13q14 was performed in 28 patients with multiple myeloma (MM) receiving high-dose therapy followed by autologous (n=24) or allogeneic (n=4) stem cell support. Eleven...
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Article
Interphase fluorescence in situ hybridization analysis of fibroblast-like synoviocytes of patients with rheumatoid arthritis and osteoarthritis
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Article
Deletions of chromosome 13q in monoclonal gammopathy of undetermined significance
Since deletion of chromosome 13q is a clinically relevant feature in multiple myeloma (MM), we analyzed bone marrow plasma cells from 29 patients with monoclonal gammopathy of undetermined significance (MGUS) ...
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Article
Hematopoietic donor chimerism and graft-versus-myeloma effect in relapse of multiple myeloma after allogeneic bone marrow transplantation
A large group of patients relapsing after allogeneic bone marrow transplantation (BMT) have obtained remission after infusion of leukocytes from their original donor, suggesting a graft-versus-myeloma effect....
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Article
Inherent robust stability of driver support systems
Presented are the fact that the transfer function from the front steering angle to yaw rate is strictly positive real, irrespective of the uncertain mass and uncertain velocity, how to determine the positivity...
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Article
Open AccessDeletions of the region 17p11-13 in advanced melanoma revealed by cytogenetic analysis and fluorescence in situ hybridization
The significance of the p53 tumour-suppressor gene in the oncogenesis of a variety of malignant tumours has been demonstrated over recent years. However, the role of p53 in human malignant melanoma is still un...
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Article
A case of bone marrow mastocytosis associated with multiple myeloma
Mastocytosis is a term used for a spectrum of disorders characterized by abnormal growth and accumulation of mast cells. The cutaneous variants of the disease have to be distinguished from systemic mastocytos...
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Article
Chromosomal imbalances in primary and metastatic pancreatic carcinoma as detected by interphase cytogenetics: basic findings and clinical aspects
To date, cytogenetic studies on pancreatic carcinoma are rare, and little is known about the frequency of cytogenetic aberrations in primary carcinomas compared with metastatic tumour cells. We therefore evalu...
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Article
Scanning force microscopy on heavy-ion tracks in muscovite mica: track diameter versus energy loss and loading force
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Article
In vitro DNA-based predator-prey system with oscillatory kinetics
A coupled system of two isothermal in vitro DNA/RNA amplification reactions using different primers is modeled kinetically with realistic rate parameters and shown to exhibit oscillatory behavior in a flow reacto...