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  1. No Access

    Chapter

    Purged Autologous Bone Marrow: Better or Worse than Circulating Stem Cells?

    Autologous bone marrow tranplantation (ABMT) has been extensively used as treatment for hematological malignancies over the last decade [1]. The main cause of failure after ABMT is relapse or recurrence of the...

    J. Reiffers in Advances in haemapheresis (1991)

  2. No Access

    Article

    Allogeneic bone marrow transplantation for acute leukemia in patients over the age of 40 years

    Extension of allogeneic transplants to older patients has been limited by a high risk of transplant-related death and graft-versus-host disease. To evaluate the feasibility in older patients, a retrospective a...

    J-Y Cahn, M Labopin, A Schattenberg, J Reiffers, R Willemze, R Zittoun… in Leukemia (1997)

  3. No Access

    Article

    All-trans retinoic acid potentiates the inhibitory effects of interferon α on chronic myeloid leukemia progenitors in vitro

    All-trans retinoic acid (ATRA) has recently been shown to synergise with the inhibitory effect of interferon alpha (IFNα) on the growth of malignant cells isolated from solid tumors. We investigated whether ATRA ...

    FX Mahon, H Chahine, C Barbot, V Pigeonnier, B Jazwiec, J Reiffers, J Ripoche in Leukemia (1997)

  4. No Access

    Article

    Early allogeneic transplantation favorably influences the outcome of adult patients suffering from acute myeloid leukemia

    Allogeneic BMT for patients with acute myeloid leukemia (AML) is presently a reference therapy. The indications for this therapy mainly rely upon prognostic factors, and their importance is constantly reassess...

    E Jourdan, D Maraninchi, J Reiffers, E Gluckman, B Rio… in Bone Marrow Transplantation (1997)

  5. No Access

    Article

    Gene transfer of the uroporphyrinogen III synthase cDNA into haematopoietic progenitor cells in view of a future gene therapy in congenital erythropoietic porphyria

    Congenital erythropoietic porphyria (CEP) is an inherited metabolic disorder characterized by an overproduction and accumulation of porphyrins in bone marrow. This autosomal recessive disease results from a de...

    F. Mazurier, F. Moreau-Gaudry, S. Salesse… in Journal of Inherited Metabolic Disease (1997)

  6. No Access

    Article

    European results of matched unrelated donor bone marrow transplantation for chronic myeloid leukemia. Impact of HLA class II matching

    We have retrospectively analyzed the impact of prognostic factors on the outcome of serologically HLA-matched unrelated donor (UD) BMT for CML. For this purpose, we have studied a cohort of 366 patients transp...

    A Devergie, JF Apperley, M Labopin, A Madrigal, N Jacobsen… in Bone Marrow Transplantation (1997)

  7. No Access

    Article

    Long-term results after allogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic phase: a report from the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation

    The purpose of this study was to determine the long-term results of allogeneic bone marrow transplantation for chronic myeloid leukemia. A retrospective analysis was carried out of the outcome of 373 consecuti...

    F van Rhee, RM Szydlo, J Hermans, A Devergie, F Frassoni… in Bone Marrow Transplantation (1997)

  8. No Access

    Article

    Flow cytometry CD45 gating for immunophenoty** of acute myeloid leukemia

    A flow cytometry method has been introduced into the routine investigation of whole bone marrow samples following red blood cell lysis on the basis of a primary CD45/side scatter (SSC) gating procedure. Blast ...

    F Lacombe, F Durrieu, A Briais, P Dumain, F Belloc, E Bascans, J Reiffers… in Leukemia (1997)

  9. No Access

    Article

    Endothelial cell support of hematopoiesis is differentially altered by IL-1 and glucocorticoids

    We investigated the ability of endothelial cells (EC) to support hematopoiesis in contact and non-contact cocultures with isolated CD34+ or CD34+/CD38low cells. In the absence of exogenous cytokines, umbilical ve...

    B Jazwiec, A Solanilla, C Grosset, F-X Mahon, M Dupouy, V Pigeonnier-Lagarde… in Leukemia (1998)

  10. No Access

    Article

    Factors affecting both peripheral blood progenitor cell mobilization and hematopoietic recovery following autologous blood progenitor cell transplantation in multiple myeloma patients: a monocentric study

    The aim of the study was to analyze the factors influencing peripheral blood progenitor cell (PBPC) collection after high-dose cyclophosphamide (HDCYC) (7 g/m2) and hematopoietic recovery after autologous transpl...

    G Marit, F Thiessard, C Faberes, P Cony-Makhoul, JM Boiron, P Bernard… in Leukemia (1998)

  11. No Access

    Article

    Stable mixed chimerism without relapse after related allogeneic umbilical cord blood transplantation in a child with severe aplastic anemia

    Umbilical cord blood (UCB) cells from HLA-matched donors are used as an alternative to bone marrow for allogeneic transplantation and reports of successful UCB transplantation in patients with severe aplastic ...

    J-M Boiron, S Cotterêt, P Cony-Makhoul, P Merel, M Micheau… in Bone Marrow Transplantation (1998)

  12. No Access

    Article

    Factors influencing haemopoietic recovery following chemotherapy-mobilised autologous peripheral blood progenitor cell transplantation for haematological malignancies: a retrospective analysis of a 10-year single institution experience

    We retrospectively analysed the factors that influenced rate of haemopoietic recovery (HR) in 243 patients after transplantation with chemotherapy-mobilised autologous peripheral blood progenitor cells (PBPC)....

    RM Lowenthal, C Fabères, G Marit, JM Boiron, P Cony-Makhoul… in Bone Marrow Transplantation (1998)

  13. No Access

    Article

    Chronic myeloid leukemia in first chronic phase not responding to α-interferon: outcome and prognostic factors after autologous transplantation

    We report the data obtained from the European Bone Marrow Transplant Registry for patients with CML who received autologous transplantation (AT) in chronic phase (CP) because α-IFN was ineffective. Forty-one C...

    J-M Boiron, J-Y Cahn, G Meloni, C Carlo-Stella, G Bandini… in Bone Marrow Transplantation (1999)

  14. No Access

    Article

    Allogeneic bone marrow transplant or second autograft in patients with acute leukemia who relapse after an autograft

    Among 2752 patients with acute leukemia who had recurrent leukemia after autograft in remission and were reported to the EBMT, 94 underwent an allogeneic bone marrow transplant and 74 received a second autogra...

    O Ringdén, M Labopin, F Frassoni, GF Sanz, F Demeocq… in Bone Marrow Transplantation (1999)

  15. No Access

    Article

    Autologous stem cell transplantation in chronic myeloid leukemia: a single center experience

    Between 1980 and 1996, we transplanted 72 patients with CML using blood stem cells collected at diagnosis before treatment and without any mobilization. The median age of patients at diagnosis was 47.5 years (...

    A Pigneux, C Faberes, JM Boiron, FX Mahon, P Cony-Makhoul… in Bone Marrow Transplantation (1999)

  16. No Access

    Article

    Syngeneic transplantation in multiple myeloma – a case-matched comparison with autologous and allogeneic transplantation

    Twenty-five patients with multiple myeloma received bone marrow grafts (n = 24) or peripheral blood stem cells (n = 1) from twin donors. The outcome was compared in a case-matched analysis to 125 patients who und...

    G Gahrton, H Svensson, B Björkstrand, J Apperley, K Carlson… in Bone Marrow Transplantation (1999)

  17. No Access

    Article

    Expression of Flt3-ligand by the endothelial cell

    Flt3-ligand (FL) is a cytokine that is of paramount importance in the proliferation of primitive hematopoietic progenitors. In this study, we show that endothelial cells (EC) produce large amounts of soluble F...

    A Solanilla, C Grosset, C Lemercier, M Dupouy, FX Mahon, K Schweitzer… in Leukemia (2000)

  18. No Access

    Article

    The dismal outcome in patients with acute leukaemia who relapse after an autograft is improved if a second autograft or a matched allograft is performed

    All patients receiving autografts for acute leukaemia in remission between 1 January 1981 and 31 December 1996 and reported to the European Group for Blood and Marrow Transplantation and had a relapse, were in...

    O Ringdén, M Labopin, NC Gorin, G Meloni, D Blaise… in Bone Marrow Transplantation (2000)

  19. No Access

    Article

    Autologous blood cell vs marrow transplantation for acute myeloid leukemia in complete remission: an EBMT retrospective analysis

    In order to compare autologous bone marrow (BMT) and blood cell transplantation (BCT) in patients with acute myeloid leukemia (AML) in first remission (CR1), we retrospectively reviewed the data of 1393 patien...

    J Reiffers, M Labopin, M Sanz, M Korbling, D Blaise… in Bone Marrow Transplantation (2000)

  20. No Access

    Article

    Study of apoptosis-related responses of leukemic blast cells to in vitro anthracycline treatment

    Anthracyclines trigger an apoptotic cell death but their molecular targets are not totally explored. We investigated the apoptotic response of blast cells and lymphocytes from medullary samples of 31 de novo acut...

    M-A Belaud-Rotureau, F Durrieu, G Labroille, F Lacombe, O Fitoussi, P Agape… in Leukemia (2000)

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