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Article
Open AccessEffects of daily artificial gravity training on orthostatic tolerance following 60-day strict head-down tilt bedrest
Orthostatic intolerance commonly occurs following immobilization or space flight. We hypothesized that daily artificial gravity training through short-arm centrifugation could help to maintain orthostatic tole...
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Article
Open AccessTransitions for older people with learning disabilities and behaviours that challenge others, and their family carers: a merged protocol for two rapid sco** reviews of evidence
There are over 1 million adults with a learning disability in the UK, of whom approximately 20% displaying behaviours that challenge others. Two thirds of people with learning disabilities live in the family h...
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Article
Eye changes in space
More than ever research into changes in the eye caused by long-term space flight is becoming the focus of the international and national space agencies National Aeronautics and Space Administration (NASA), Eur...
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Article
Augenveränderungen im All
Mehr denn je rückt die Erforschung der Veränderungen am Auge, die durch den Aufenthalt im All verursacht werden, ins Zentrum des Interesses der internationalen und nationalen Weltraumagenturen NASA (National A...
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Article
Lageabhängigkeit des Augeninnendruckes bei Glaukompatienten
Der menschliche Augeninnendruck (intraokularer Druck [IOD]) ist abhängig von der Lage des Kopfes im Verhältnis zum Körper im Raum. Physiologisch steigt der IOD bei liegender Position im Vergleich zur aufrechte...
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Article
Baroreflexaktivierungstherapie bei therapieresistenter Hypertonie
Die Hemmung eines erhöhten Sympathikotonus stellt für verschiedene Erkrankungen ein effektives und in vielen Fällen kausales Therapieprinzip dar. Neben pharmakologischen Ansätzen mit Betablockern oder zentrale...
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Article
Open AccessThe effects of angiotensin receptor neprilysin inhibition by sacubitril/valsartan on adipose tissue transcriptome and protein expression in obese hypertensive patients
Increased activation of the renin-angiotensin system is involved in the onset and progression of cardiometabolic diseases, while natriuretic peptides (NP) may exert protective effects. We have recently demonst...
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Chapter and Conference Paper
MASEV: A MAS for the Analysis of Electric Vehicle Charging Stations Location
Electric vehicles are already a reality in many cities around the world. However, the penetration of the electric vehicle depends on several factors, including the existence of an adequate network of charging ...
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Article
The UCP2-866G/A Polymorphism Could be Considered as a Genetic Marker of Different Functional Prognosis in Ischemic Stroke After Recanalization
Recent studies based on experimental animal models of stroke have suggested that uncoupling protein 2 (UCP2), an inner mitochondrial membrane protein that is thought to regulate energy metabolism and reduce re...
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Article
Barorezeptorakivierungstherapie bei therapierefraktärer Hypertonie: Indikation und Patientenselektion
Zur Behandlung der therapierefraktären Hypertonie (trHTN) steht seit einigen Jahren die Möglichkeit der Barorezeptoraktivierungstherapie (BAT) zur Verfügung. Das Verfahren wird derzeit in Deutschland an einer ...
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Article
Open AccessDecipher correlation patterns post prostatectomy: initial experience from 2 342 prospective patients
Currently, there are multiple commercially available RNA-based biomarkers that are Medicare approved and suggested for use by the National Comprehensive Cancer Network guidelines. There is uncertainty as to wh...
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Article
Open AccessSodium MRI in Multiple Sclerosis is Compatible with Intracellular Sodium Accumulation and Inflammation-Induced Hyper-Cellularity of Acute Brain Lesions
The cascade of inflammatory pathogenetic mechanisms in multiple sclerosis (MS) has no specific conventional MRI correlates. Clinicians therefore stipulate improved imaging specificity to define the pathologica...
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Article
Pharmacological MRI (phMRI) of the Human Central Nervous System
Pharmacological magnetic resonance imaging (phMRI) of the central nervous system (CNS) addresses the increasing demands in the biopharma industry for new methods that can accurately predict, as early as possib...
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Article
Open AccessThe LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been associated with Parkinson’s disease, and its inhibition opens potential new therapeutic options. Among the drug inhibitors of both wild-type an...
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Article
Open AccessAutophagy and mitochondrial alterations in human retinal pigment epithelial cells induced by ethanol: implications of 4-hydroxy-nonenal
Retinal pigment epithelium has a crucial role in the physiology and pathophysiology of the retina due to its location and metabolism. Oxidative damage has been demonstrated as a pathogenic mechanism in several...
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Chapter
Analysis of Networked Systems
In this chapter fundamental properties of networked control systems are discussed that characterize obstructions to and requirements for the control of interconnections through digital channels. On the one han...
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Article
Open AccessLatrepirdine is a potent activator of AMP-activated protein kinase and reduces neuronal excitability
Latrepirdine/Dimebon is a small-molecule compound with attributed neurocognitive-enhancing activities, which has recently been tested in clinical trials for the treatment of Alzheimer’s and Huntington’s diseas...
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Article
Open AccessPhenoty** and outcome on contemporary management in a German cohort of patients with peripartum cardiomyopathy
Peripartum cardiomyopathy (PPCM) is a life-threatening heart disease develo** towards the end of pregnancy or in the months following delivery in previously healthy women in terms of cardiac disease. Enhance...
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Article
Positionspapier zur Bedeutung psychosozialer Faktoren in der Kardiologie
Die rasche Weiterentwicklung der psychokardiologischen Forschung, aber auch die wachsende Verankerung psychosozialer Fragestellungen im klinischen Alltag haben die Klinische Kommission der DGK bewogen, einer A...
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Article
Asymmetric dimethylarginine, arginine and homoarginine at 11–13 weeks’ gestation and preeclampsia: a case–control study
The aim of this study was to investigate whether the nitric oxide (NO) pathway is altered in pregnancies that develop preeclampsia (PE). This was a nested case–control study of screening for PE, in which plasm...
