42 Result(s)

Article

The mutational oncoprint of recurrent cytogenetic abnormalities in adult patients with de novo acute myeloid leukemia

Recurrent chromosomal abnormalities and gene mutations detected at the time of diagnosis of acute myeloid leukemia (AML) are associated with particular disease features, treatment response and survival of AML ...

A-K Eisfeld, K Mrózek, J Kohlschmidt, D Nicolet, S Orwick, C J Walker… in Leukemia (2017)

Article

PLCG2 C2 domain mutations co-occur with BTK and PLCG2 resistance mutations in chronic lymphocytic leukemia undergoing ibrutinib treatment

D Jones, J A Woyach, W Zhao, S Caruthers, H Tu, J Coleman, J C Byrd… in Leukemia (2017)

Article

Leukemia-cell proliferation and disease progression in patients with early stage chronic lymphocytic leukemia

The clinical course of patients with recently diagnosed early stage chronic lymphocytic leukemia (CLL) is highly variable. We examined the relationship between CLL-cell birth rate and treatment-free survival (...

E J Murphy, D S Neuberg, L Z Rassenti, G Hayes, R Redd, C Emson, K Li… in Leukemia (2017)

Article

Mutations in the CCND1 and CCND2 genes are frequent events in adult patients with t(8;21)(q22;q22) acute myeloid leukemia

Core-binding factor acute myeloid leukemia (CBF-AML) is defined by the presence of either t(8;21)(q22;q22)/RUNX1-RUNX1T1 or inv(16)(p13.1q22)/t(16;16)(p13.1;q22)/CBFB-MYH11. The resulting fusion genes require a ‘...

A-K Eisfeld, J Kohlschmidt, S Schwind, D Nicolet, J S Blachly, S Orwick, C Shah… in Leukemia (2017)

Article

Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies

The nuclear export receptor, Exportin 1 (XPO1), mediates transport of growth-regulatory proteins, including tumor suppressors, and is overactive in many cancers, including chronic lymphocytic leukemia (CLL), a...

Z A Hing, H Y J Fung, P Ranganathan, S Mitchell, D El-Gamal, J A Woyach… in Leukemia (2016)

Article

Adult acute myeloid leukemia with trisomy 11 as the sole abnormality is characterized by the presence of five distinct gene mutations: MLL-PTD, DNMT3A, U2AF1, FLT3-ITD and IDH2

A-K Eisfeld, J Kohlschmidt, K Mrózek, J S Blachly, D Nicolet, K Kroll, S Orwick… in Leukemia (2016)

Article

Clinical features and gene- and microRNA-expression patterns in adult acute leukemia patients with t(11;19)(q23;p13.1) and t(11;19)(q23;p13.3)

B Bhatnagar, J S Blachly, J Kohlschmidt, A-K Eisfeld, S Volinia, D Nicolet… in Leukemia (2016)

Article

Incidence and description of autoimmune cytopenias during treatment with ibrutinib for chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is frequently complicated by secondary autoimmune cytopenias (AICs). Ibrutinib is an irreversible inhibitor of Bruton’s tyrosine kinase approved for the treatment of relapsed...

K A Rogers, A S Ruppert, A Bingman, L A Andritsos, F T Awan, K A Blum… in Leukemia (2016)

Article

Autologous hematopoietic stem cell transplant induces the molecular aging of T-cells in multiple myeloma

A Rosko, C Hofmeister, D Benson, Y Efebera, Y Huang… in Bone Marrow Transplantation (2015)

Article

Dinaciclib is a novel cyclin-dependent kinase inhibitor with significant clinical activity in relapsed and refractory chronic lymphocytic leukemia

Dinaciclib (SCH727965) is a selective CDKi chosen for clinical development based upon a favorable therapeutic index in cancer xenograft models. We performed a phase I dose escalation study of dinaciclib in rel...

J Flynn, J Jones, A J Johnson, L Andritsos, K Maddocks, S Jaglowski, J Hessler… in Leukemia (2015)

Article

miR-155 expression is associated with chemoimmunotherapy outcome and is modulated by Bruton’s tyrosine kinase inhibition with Ibrutinib

D Guinn, A S Ruppert, K Maddocks, S Jaglowski, A Gordon, T S Lin, R Larson… in Leukemia (2015)

Article

Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia

Selective cytotoxicity to cancer cells without compromising their normal counterparts pose a huge challenge for traditional drug design. Here we developed a tumor antigen-targeted delivery of immunonanoparticl...

R Mani, Y Mao, F W Frissora, C-L Chiang, J Wang, Y Zhao, Y Wu, B Yu, R Yan… in Leukemia (2015)

Article

Mitochondrial priming of chronic lymphocytic leukemia patients associates Bcl-x_L dependence with alvocidib response

W E Pierceall, S L Warner, R J Lena, C Doykan, N Blake, M Elashoff, D V Hoff… in Leukemia (2014)

Article

Circulating miRNA markers show promise as new prognosticators for multiple myeloma

A Rocci, C C Hofmeister, S Geyer, A Stiff, M Gambella, L Cascione, J Guan… in Leukemia (2014)

Article

The CD37-targeted antibody–drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model

Therapeutic regimens for chronic lymphocytic leukemia (CLL) have increasingly utilized monoclonal antibodies since the chimeric anti-CD20 antibody rituximab was introduced. Despite improved clinical outcomes, ...

K A Beckwith, F W Frissora, M R Stefanovski, W H Towns, C Cheney, X Mo… in Leukemia (2014)

Article

Impact of targeted therapy on outcome of chronic lymphocytic leukemia patients with relapsed del(17p13.1) karyotype at a single center

D M Stephens, A S Ruppert, J A Jones, J Woyach, K Maddocks, S M Jaglowski… in Leukemia (2014)

Article

Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells

Y Zhong, D El-Gamal, J A Dubovsky, K A Beckwith, B K Harrington, K E Williams… in Leukemia (2014)

Article

Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia

Histone deacetylase (HDAC) inhibitors either alone or in combination with hypomethylating agents have limited clinical effect in acute myeloid leukemia (AML). Previously, we demonstrated that AML patients with...

A Mims, A R Walker, X Huang, J Sun, H Wang, R Santhanam, A M Dorrance, C Walker… in Leukemia (2013)