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Open AccessCan you feel the force just right? Tactile force feedback for training of minimally invasive surgery—evaluation of vibration feedback for adequate force application
Tissue handling is a crucial skill for surgeons and is challenging to learn. The aim of this study was to develop laparoscopic instruments with different integrated tactile vibration feedback by varying differ...
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Article
Open AccessCorrelation of microscopic tumor extension with tumor microenvironment in esophageal cancer patients
In the era of image-guided adaptive radiotherapy, definition of the clinical target volume (CTV) is a challenge in various solid tumors, including esophageal cancer (EC). Many tumor microenvironmental factors,...
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Article
Der digitale Operationssaal
Am zentralen Arbeitsplatz des Chirurgen hat die Digitalisierung im Operationssaal besondere Auswirkungen auf die chirurgische Arbeitsweise. Von der intraoperativen Schnittbildgebung und Sonographie über funkti...
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Article
Open AccessExploring semantic consistency in unpaired image translation to generate data for surgical applications
In surgical computer vision applications, data privacy and expert annotation challenges impede the acquisition of labeled training data. Unpaired image-to-image translation techniques have been explored to aut...
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Article
Open AccessOne model to use them all: training a segmentation model with complementary datasets
Understanding surgical scenes is crucial for computer-assisted surgery systems to provide intelligent assistance functionality. One way of achieving this is via scene segmentation using machine learning (ML). ...
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Article
Therapiestrategien beim Rektumkarzinomrezidiv
Multimodale Therapieansätze mit neoadjuvanter Strahlen- und Chemotherapie gefolgt von onkologischer und totaler mesorektaler Resektion (TME) haben die Rezidivrate selbst bei lokal fortgeschrittenen Rektumkarzi...
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Article
Künstliche Intelligenz in der onkologischen Chirurgie
Künstliche Intelligenz (KI) durchdringt alle Bereiche der Medizin. Ziel dieser Arbeit ist eine Zusammenfassung des aktuellen Stands von KI in der onkologischen Chirurgie und ein Ausblick auf zukünftige Forschu...
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Article
Open AccessThe development of tissue handling skills is sufficient and comparable after training in virtual reality or on a surgical robotic system: a prospective randomized trial
Virtual reality is a frequently chosen method for learning the basics of robotic surgery. However, it is unclear whether tissue handling is adequately trained in VR training compared to training on a real robo...
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Article
Open AccessPreoperative anaemia in distal pancreatectomy: a propensity-score matched analysis
Preoperative anaemia is a prevalent morbidity predictor that adversely affects short- and long-term outcomes of patients undergoing surgery. This analysis aimed to investigate preoperative anaemia and its detr...
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Article
Open AccessImpact of dehydration on laparoscopic performance: a prospective, open-label, randomized cross-over trial
During laparoscopic surgery, surgeons may experience prolonged periods without fluid intake, which might impact surgical performance, yet there are no objective data investigating this issue. Therefore, the ai...
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Article
Open AccessSatisfaction of surgeons with the current state of training in minimally invasive surgery: a survey among German surgeons
Minimally invasive surgery (MIS) requires intense education and training with structured supervision and feedback. However, a standardized training structure is lacking in Germany. This nationwide survey aimed...
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Article
Open AccessPreoperative IL-8 levels as prognostic indicators of overall survival: an extended follow-up in a prospective cohort with colorectal liver metastases
CRC with liver metastases is a major contributor to cancer-related mortality. Despite advancements in liver resection techniques, patient survival remains a concern due to high recurrence rates. This study see...
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Article
Open AccessStratifying esophago-gastric cancer treatment using a patient-derived organoid-based threshold
This study sought to determine the value of patient-derived organoids (PDOs) from esophago-gastric adenocarcinoma (EGC) for response prediction to neoadjuvant chemotherapy (neoCTx).
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Article
Open AccessUltra-sensitive CTC-based liquid biopsy for pancreatic cancer enabled by large blood volume analysis
The limited sensitivity of circulating tumor cell (CTC) detection in pancreatic adenocarcinoma (PDAC) stems from their extremely low concentration in the whole circulating blood, necessitating enhanced detecti...
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Article
Open AccessActive learning for extracting surgomic features in robot-assisted minimally invasive esophagectomy: a prospective annotation study
With Surgomics, we aim for personalized prediction of the patient's surgical outcome using machine-learning (ML) on multimodal intraoperative data to extract surgomic features as surgical process characteristi...
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Article
Open AccessCorrection: COMPASS: deCOMPressing stomA and two-Stage elective resection vs. emergency reSection in patients with left-sided obstructive colon cancer
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Article
Open AccessSerum immune checkpoint profiling identifies soluble CD40 as a biomarker for pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) responds poorly to systemic treatment, including new immunotherapeutic approaches. Biomarkers are urgently needed for early disease detection, patient stratification for...
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Article
Open AccessCOMPASS: deCOMPressing stomA and two-Stage elective resection vs. emergency reSection in patients with left-sided obstructive colon cancer
Colorectal cancer stands as a prevalent cause of cancer-related mortality, necessitating effective treatment strategies. Acute colonic obstruction occurs in approximately 20% of patients and represents a surgi...
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Article
Open AccessInterleukin-8 is superior to CRP for the prediction of severe complications in a prospective cohort of patients undergoing major liver resection
Early detection of severe complications may reduce morbidity and mortality in patients undergoing hepatic resection. Therefore, we prospectively evaluated a panel of inflammatory blood markers for their value ...
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Article
Open AccessThree-year survival and distribution of lymph node metastases in gastric cancer following neoadjuvant chemotherapy: results from a European randomized clinical trial
Adequate lymphadenectomy is an important step in gastrectomy for cancer, with a modified D2 lymphadenectomy being recommended for advanced gastric cancers. When assessing a novel technique for the treatment of...
