-
Article
Open AccessUltra-sensitive CTC-based liquid biopsy for pancreatic cancer enabled by large blood volume analysis
The limited sensitivity of circulating tumor cell (CTC) detection in pancreatic adenocarcinoma (PDAC) stems from their extremely low concentration in the whole circulating blood, necessitating enhanced detecti...
-
Article
Risk factors for post-operative ileus in patients with anterior resection for rectal cancer. A single center cohort
Postoperative ileus (POI) is a major cause of morbidity in patients undergoing colorectal surgery. The aim of our study was to evaluate potential risk factors for POI in cases with anterior resection for recta...
-
Article
Open AccessDistribution of gastrointestinal neuroendocrine tumors in Europe: results from a retrospective cross-sectional study
Gastrointestinal (non-pancreatic) neuroendocrine tumors (GI-NETs) represent a rare but increasingly common tumor entity. Prognosis and biological behavior of these tumors is extremely heterogenous and largely ...
-
Article
Open AccessTwo-port versus three-port video-assisted thoracoscopic surgery for primary spontaneous pneumothorax: feasibility, postoperative outcome and long-term recurrence rates
Two-port VATS (2-P-VATS) and three-port VATS (3-P-VATS) are well-established techniques for surgical therapy of primary spontaneous pneumothorax (PSP). However, comparisons of both techniques in terms of posto...
-
Article
Open AccessPancreatic ductal adenocarcinoma concomitant with pancreatic metastases of clear-cell renal cell carcinoma: a case report
Metastatic spread to the pancreas is a rare event. Renal cell carcinoma represents one possible site of origin of pancreatic metastases. Renal cell carcinoma often metastasizes late and exclusively to the panc...
-
Chapter
Minimal Residual Disease in Head and Neck Cancer and Esophageal Cancer
Malignant epithelial tumors of the upper digestive tract are a major cause of cancer-related death worldwide. The most common of these cancers are head and neck squamous cell carcinomas (HNSCC) and esophageal ...
-
Article
Open AccessDisseminated tumour cells with highly aberrant genomes are linked to poor prognosis in operable oesophageal adenocarcinoma
Chromosomal instability (CIN) has repeatedly been identified as a prognostic marker. Here we evaluated the percentage of aberrant genome per cell (PAG) as a measure of CIN in single disseminated tumour cells (...
-
Article
Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments
Hypoxia is a poor-prognosis microenvironmental hallmark of solid tumours, but it is unclear how it influences the fate of disseminated tumour cells (DTCs) in target organs. Here we report that hypoxic HNSCC an...
-
Article
Open AccessSnail1 expression in colorectal cancer and its correlation with clinical and pathological parameters
Snail1 is a transcription regulator of E-cadherin. The loss of E-cadherin seems to be a crucial step in the process of Epithelial-mesenchymal transition (EMT). EMT initiates invasion and proliferation in many ...
