19 Result(s)
within
Jürgen May
Biomedicine
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Article
Open AccessCarriage of ESBL-producing Klebsiella pneumoniae and Escherichia coli among children in rural Ghana: a cross-sectional study
Extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae (ESBL-KP) and Escherichia coli (ESBL-EC) present a high burden in both communities and healthcare sectors, leading to difficult-to-treat inf...
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Open AccessClustering of Cryptosporidium species infections among sheep and cattle but not children in remote highland communities of Madagascar
The aim of this study was to identify local transmission patterns of Cryptosporidium spp. infections among livestock and humans in four extremely rural and remote highland communities in Madagascar.
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Open AccessChallenges in the clinical development pathway for triple and multiple drug combinations in the treatment of uncomplicated falciparum malaria
The addition of a third anti-malarial drug matching the pharmacokinetic characteristics of the slowly eliminated partner drug in artemisinin-based combination therapy (ACT) has been proposed as new therapeutic...
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Article
Open AccessSerum cytokine responses in Rickettsia felis infected febrile children, Ghana
The intracellular pathogen Rickettsia felis causes flea-borne spotted fever and is increasingly recognized as an emerging cause of febrile illness in Africa, where co-infection with Plasmodium falciparum is commo...
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Open AccessDiagnostic performance of the Luminex xTAG gastrointestinal pathogens panel to detect rotavirus in Ghanaian children with and without diarrhoea
Rotavirus is one of the leading causes of childhood diarrhoea worldwide. The highest disease burden is seen in resource-constrained settings of sub-Saharan Africa. Recently, commercial multiplex PCR panels pro...
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Open AccessSpatial heterogeneity of malaria in Ghana: a cross-sectional study on the association between urbanicity and the acquisition of immunity
Malaria incidence has declined considerably over the last decade. This is partly due to a scale-up of control measures but is also attributed to increasing urbanization. This study aimed to analyse the associa...
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Open AccessPrevalence of malaria parasitaemia in school children from two districts of Ghana earmarked for indoor residual spraying: a cross-sectional study
Indoor residual spraying (IRS) is considered a valuable transmission control measure against malaria but exact efficacy data are not available for many epidemiological settings. This study was conducted to det...
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Open AccessMolecular epidemiology and seroprevalence in asymptomatic Plasmodium falciparum infections of Malagasy pregnant women in the highlands
Malaria epidemiology in Madagascar is classified into four different areas, ranging from unstable seasonal transmission in the highlands to hyperendemic perennial transmission areas in the costal level. Most m...
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Malaria transmission in two rural communities in the forest zone of Ghana
Malaria transmission was assessed in two rural communities, Kona and Afamanaso in Sekyere South district, Ashanti Region, in the forest zone of Ghana to provide baseline data for ongoing clinical studies and t...
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Article
Open AccessMultiplicity of Plasmodium falciparum infection following intermittent preventive treatment in infants
Intermittent preventive treatment in infants with sulphadoxine-pyrimethamine (IPTi-SP) reduces malaria morbidity by 20% to 33%. Potentially, however, this intervention may compromise the acquisition of immunit...
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Article
Open AccessPrincipal component analysis of socioeconomic factors and their association with malaria in children from the Ashanti Region, Ghana
The socioeconomic and sociodemographic situation are important components for the design and assessment of malaria control measures. In malaria endemic areas, however, valid classification of socioeconomic fac...
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Open AccessMalaria transmission in non-endemic areas: case report, review of the literature and implications for public health management
In non-endemic areas, malaria is rare and locally acquired infections, particularly with Plasmodium falciparum, are exceptional events. The diagnosis is, therefore, likely to be delayed or missed in patients with...
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Open AccessSickle cell trait (HbAS) and stunting in children below two years of age in an area of high malaria transmission
While the protective effects of sickle cell trait (HbAS) against severe malaria and the resulting survival advantage are well known, the impact on the physical development in young children remains unclear. Th...
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Open AccessA randomized trial on effectiveness of artemether-lumefantrine versus artesunate plus amodiaquine for unsupervised treatment of uncomplicated Plasmodium falciparum malaria in Ghanaian children
Numerous trials have demonstrated high efficacy and safety of artemisinin-based combination therapy (ACT) under supervised treatment. In contrast, effectiveness studies comparing different types of ACT applied...
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Article
Open AccessTherapeutic and prophylactic effect of intermittent preventive anti-malarial treatment in infants (IPTi) from Ghana and Gabon
Intermittent preventive treatment in infants (IPTi) with sulphadoxine-pyrimethamine (SP) reduces the incidence of malaria episodes in young children. The exact mechanism by which the protective effect is media...
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Article
The impact of IgG antibodies to recombinant Plasmodium falciparum 732var CIDR-1α domain in mothers and their newborn babies
Different domains of a novel full-length var gene (termed 732var) isolated from a placenta of a malaria-infected woman were expressed in Escherichia coli as recombinant proteins and analysed biochemically and imm...
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Article
DPB1 * BR: an Mhc class II DPB1 allele (DPB1 * 6601) of negroid origin
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Article
DPB1 * BR: anMhc class IIDPB1 allele (DPB1 * 6601) of negroid origin
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Article
DPA1 *02012: a DPA1 *0201-related Mhc class II allele in West Africa
