![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings
We recently found that renal carbonic anhydrase (CA) is involved in the reabsorption of inorganic nitrite (NO2−), an abundant reservoir of nitric oxide (NO) in tissues and cells. Impaired NO synthesis in the endo...
-
Article
Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease
Elevated circulating concentrations of total l-homocysteine (thCys) and free asymmetric dimethylarginine (ADMA) are long-established cardiovascular risk factors. Low circulating l-homoarginine (hArg) concentratio...
-
Article
Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free l-arginine in humans
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis, whereas l-arginine (Arg) and l-homoarginine (hArg) serve as substrates for NO synthesis. ADMA and other methylated arg...
-
Article
Effects of chronic oral l-arginine administration on the l-arginine/NO pathway in patients with peripheral arterial occlusive disease or coronary artery disease: l-Arginine prevents renal loss of nitrite, the major NO reservoir
Despite saturation of nitric oxide (NO) synthase (NOS) by its substrate l-arginine (Arg), oral and intravenous supplementation of Arg may enhance NO synthesis, a phenomenon known as “The l-arginine paradox”. Yet,...
-
Article
Aortic thrombus and pulmonary embolism in a patient with hyperhomocysteinemia
Background A 32-year-old man presented at hospital with persistent pain, hypothermia and paraesthesia in his right leg, caused by embolic occlusion of all three large arteries as a result of massive thrombi in th...
-
Article
Pregraduate teaching clinical pharmacology in Germany
-
Article
Effects of carvedilol on oxidative stress in human endothelial cells and healthy volunteers
Carvedilol is a nonselective β- and α1-receptor antagonist with additional antioxidant properties in vitro. In this study, we assessed the antioxidative potential of carvedilol in cell culture and in antihyperten...
-
Article
The Second Generation of COX-2 Inhibitors
The discovery of two cyclooxygenase (COX)-isoenzymes, a constitutive OX-1, serving homeostatic prostanoid synthesis, and an inducible COX-2, responsible for proinflammatory prostanoid production, led to the de...
-
Article
Blood donors on medication
Objectives: Drugs and their metabolites in transfused blood components may cause effects in the recipient. If the treated disorder is not to be regarded as an exclusion criterion from blood donation, donors on m...
-
Article
Neue nichtsteroidale Antirheumatika: Selektive Hemmstoffe der induzierbaren Cyclooxygenase
Nichtsteroidale Antirheumatika (NSAR) üben ihre antiinflammatorischen, analgetischen und antipyretischen Wirkungen durch Hemmung der Prostanoidsynthese aus. Die typischen Nebenwirkungen der NSAR und deren Inte...
-
Article
Differential inhibition of human platelet aggregation and thromboxane A2 formation by L-arginine in vivo and in vitro
We compared the effects of L-arginine (L-ARG), the precursor of endogenous NO, on platelet aggregation and thromboxane A2 formation in vivo and in vitro. Human platelet-rich plasma (PRP) was anticoagulated with c...
-
Article
Impaired Degradation of Prostaglandins and Thromboxane in Zellweger Syndrome
ABSTRACT: Cyclooxygenase products are metabolized by ω-oxidation as well as β-oxidation. Children with Zellweger syndrome (ZS) are characterized by peroxisome deficiency. To evaluate the role of peroxisomal β-...
-
Article
Analysis of leukotriene B4 as free acid and its δ-lactone by high-performance liquid chromatography: a study on the stability and formation of leukotriene B4 δ-lactone
Reversed-phase high-performance liquid chromatography (RP-HPLC) with UV detection (270 nm) was applied to study the stability of LTB4 δ-lactone in aqueous solutions and its chemical formation from LTB4. LTB4 δ-la...
-
Article
Determination of nitrite as pentafluorobenzyl derivative by RP-HPLC and UV detection with and without ion-pair extraction
A reversed-phase high-performance liquid chromatographic (RP-HPLC) method with UV detection (270 nm) for the determination of nitrite as its pentafluorobenzyl derivative with and without ion-pair extraction is...
-
Article
Analysis of nitrite and nitrate as 1-nitro-2,4,6-trimethoxybenzene derivatives by reversed-phase HPLC with UV-detection
A reversed-phase HPLC method for the determination of nitrite and nitrate in aqueous solutions, biological buffers and human urine is described. The method is based on the conversion of nitrite and nitrate int...
-
Chapter
Renal prostaglandins and leukotrienes
-
Article
Thimerosal induces endothelium-dependent vascular smooth muscle relaxations by interacting with thiol groups
-
The sulfhydryl reagent thimerosal, as well as acetylcholine and Ca2+-ionophore A23187, produced concentration...
-
-
Chapter
Investigations on Renal Prostaglandins by Gas Chromatography—Mass Spectrometry
The large number of arachidonic acid metabolites present in the mammalian kidney and urine require highly sensitive and specific analytical methods for the determination of very small amounts of chemically clo...