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Open AccessCell-type specialization is encoded by specific chromatin topologies
The three-dimensional (3D) structure of chromatin is intrinsically associated with gene regulation and cell function1–3. Methods based on chromatin conformation capture have mapped chromatin structures in neurona...
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Article
Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis
The regulatory specificity of enhancers and their interaction with gene promoters is thought to be controlled by their sequence and the binding of transcription factors. By studying Pitx1, a regulator of hindlimb...
