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Article
The transcriptional and regulatory identity of erythropoietin producing cells
Erythropoietin (Epo) is the master regulator of erythropoiesis and oxygen homeostasis. Despite its physiological importance, the molecular and genomic contexts of the cells responsible for renal Epo production...
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Article
Heads or tails: histone tail clip** regulates macrophage activity
Chromatin undergoes extensive reprogramming during immune cell differentiation. Histone clip**, an underexplored epigenetic mechanism, ensures precise macrophage development and function and is now found to ...
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Article
Variants in KIAA0825 underlie autosomal recessive postaxial polydactyly
Postaxial polydactyly (PAP) is a common limb malformation that often leads to cosmetic and functional complications. Molecular evaluation of polydactyly can serve as a tool to elucidate genetic and signaling p...
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Article
Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis
The regulatory specificity of enhancers and their interaction with gene promoters is thought to be controlled by their sequence and the binding of transcription factors. By studying Pitx1, a regulator of hindlimb...