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  1. Article

    Open Access

    ePyDGGA: automatic configuration for fitting epidemic curves

    Many epidemiological models and algorithms are used to fit the parameters of a given epidemic curve. On many occasions, fitting algorithms are interleaved with the actual epidemic models, which yields combinat...

    Josep Alòs, Carlos Ansótegui, Ivan Dotu, Manuel García-Herranz in Scientific Reports (2024)

  2. Article

    Open Access

    RNAdualPF: software to compute the dual partition function with sample applications in molecular evolution theory

    RNA inverse folding is the problem of finding one or more sequences that fold into a user-specified target structure s 0, i.e. whose minimum free energy secondary structure is identical...

    Juan Antonio Garcia-Martin, Amir H. Bayegan, Ivan Dotu, Peter Clote in BMC Bioinformatics (2016)

  3. Article

    Open Access

    Designing synthetic RNAs to determine the relevance of structural motifs in picornavirus IRES elements

    The function of Internal Ribosome Entry Site (IRES) elements is intimately linked to their RNA structure. Viral IRES elements are organized in modular domains consisting of one or more stem-loops that harbor c...

    Javier Fernandez-Chamorro, Gloria Lozano, Juan Antonio Garcia-Martin in Scientific Reports (2016)

  4. No Access

    Article

    RNA folding pathways and kinetics using 2D energy landscapes

    RNA folding pathways play an important role in various biological processes, such as (i) the hok/sok (host-killing/suppression of killing) system in E. coli to check for sufficient plasmid copy number, (ii) the c...

    Evan Senter, Ivan Dotu, Peter Clote in Journal of Mathematical Biology (2015)

  5. No Access

    Chapter and Conference Paper

    Abstract: Using the Fast Fourier Transform to Accelerate the Computational Search for RNA Conformational Switches

    We describe the broad outline of a new thermodynamics-based algorithm, FFTbor, that uses the fast Fourier transform to perform polynomial interpolation to compute the Boltzmann probability that secondary structur...

    Evan Senter, Saad Sheikh, Ivan Dotu in Research in Computational Molecular Biology (2013)

  6. No Access

    Article

    On the page number of RNA secondary structures with pseudoknots

    Let \({\mathcal {S}}\) denote the set of (possibly noncanonical) base pairs {i, j} of an RNA tertiary structure; i.e....

    Peter Clote, Stefan Dobrev, Ivan Dotu in Journal of Mathematical Biology (2012)

  7. No Access

    Article

    Boosting video tracking performance by means of Tabu Search in intelligent visual surveillance systems

    In this paper, we present a fast and efficient technique for the data association problem applied to visual tracking systems. Visual tracking process is formulated as a combinatorial hypotheses search with a h...

    Ivan Dotu, Miguel A. Patricio, A. Berlanga, J. García in Journal of Heuristics (2011)

  8. No Access

    Chapter and Conference Paper

    Real-Time Tabu Search for Video Tracking Association

    Intelligent Visual Surveillance (IVS) systems are becoming a ubiquitous security component as they aim at monitoring, in real time, persistent and transcient activities in specific environments. This paper con...

    Ivan Dotu, Pascal Van Hentenryck in Principles and Practice of Constraint Prog… (2009)

  9. No Access

    Chapter and Conference Paper

    Protein Structure Prediction with Large Neighborhood Constraint Programming Search

    Protein structure predictions is regarded as a highly challenging problem both for the biology and for the computational communities. Many approaches have been developed in the recent years, moving to increasi...

    Ivan Dotu, Manuel Cebrián in Principles and Practice of Constraint Prog… (2008)

  10. No Access

    Article

    Local Search-based Hybrid Algorithms for Finding Golomb Rulers

    The Golomb ruler problem is a very hard combinatorial optimization problem that has been tackled with many different approaches, such as constraint programming (CP), local search (LS), and evolutionary algorit...

    Carlos Cotta, Iván Dotú, Antonio J. Fernández, Pascal Van Hentenryck in Constraints (2007)

  11. No Access

    Chapter and Conference Paper

    Scheduling Social Golfers with Memetic Evolutionary Programming

    The social golfer problem (SGP) has attracted significant attention in recent years because of its highly symmetrical, constrained, and combinatorial nature. Nowadays, it constitutes one of the standard benchm...

    Carlos Cotta, Iván Dotú, Antonio J. Fernández in Hybrid Metaheuristics (2006)

  12. No Access

    Chapter and Conference Paper

    A Memetic Approach to Golomb Rulers

    Finding Golomb rulers is an extremely challenging optimization problem with many practical applications. This problem has been approached by a variety of search methods in recent years. We consider in this wor...

    Carlos Cotta, Iván Dotú in Parallel Problem Solving from Nature - PPS… (2006)

  13. No Access

    Chapter and Conference Paper

    A Note on Low Autocorrelation Binary Sequences

    The Low Autocorrelation Binary Sequences problem (LABS) is problem 005 in the CSPLIB library, where it is stated that “these problems pose a significant challenge to local search methods”. This paper presents ...

    Iván Dotú, Pascal Van Hentenryck in Principles and Practice of Constraint Prog… (2006)

  14. No Access

    Chapter and Conference Paper

    Scheduling Social Tournaments

    Tournament scheduling problems arise in many practical applications and their highly symmetric and combinatorial nature makes them particularly challenging for search algorithms. This research generalizes the ...

    Iván Dotú, Álvaro del Val in Principles and Practice of Constraint Prog… (2005)

  15. No Access

    Chapter and Conference Paper

    Scheduling Social Golfers Locally

    The scheduling of social golfers has attracted significant attention in recent years because of its highly symmetrical and combinatorial nature. In particular, it has become one of the standard benchmarks for ...

    Iván Dotú, Pascal Van Hentenryck in Integration of AI and OR Techniques in Con… (2005)

  16. No Access

    Chapter and Conference Paper

    Redundant Modeling for the QuasiGroup Completion Problem

    The Quasigroup Completion Problem (QCP) is a very challenging benchmark among combinatorial problems, and the focus of much recent interest in the area of constraint programming. [5] reports that QCPs of order...

    Iván Dotú, Alvaro del Val, Manuel Cebrián in Principles and Practice of Constraint Prog… (2003)