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Article
Exogenous midkine administration prevents cardiac remodeling in pacing-induced congestive heart failure of rabbits
Midkine (MK), a heparin-binding growth factor, has been shown to prevent cardiac remodeling after ischemic injury through its anti-apoptotic effect. Cell apoptosis is central to the pathophysiology of cardiac ...
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Article
Open AccessAccuracy of ECG-based screening for sleep-disordered breathing: a survey of all male workers in a transport company
Sleep-disordered breathing (SDB) is associated with increased risk for cardiovascular morbidity and mortality and for sleepiness-related accidents, but >75 % of the patients remain undiagnosed. We sought to de...
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Article
Acute amiodarone promotes drift and early termination of spiral wave re-entry
Intravenous application of amiodarone is commonly used in the treatment of life-threatening arrhythmias, but the underlying mechanism is not fully understood. The purpose of the present study is to investigate...
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Article
Sema3a maintains normal heart rhythm through sympathetic innervation patterning
Sympathetic innervation is critical for effective cardiac function. However, the developmental and regulatory mechanisms determining the density and patterning of cardiac sympathetic innervation remain unclear...
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Article
A case of short-coupled variant of torsade de pointes characterized by spatial heterogeneity of action potential duration and its restitution kinetics
A 21-year-old male experienced frequent episodes of polymorphic ventricular tachycardia (PVT) initiated by a closely coupled premature ventricular complex (PVC) in the absence of QT prolongation and structural...
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Chapter
The Sinoatrial Node Gap Junction Distribution and Impulse Propagation
The function of the sinoatrial (SA) node is to act as the heart’s pacemaker and for this the cells of the SA node have to be electrically connected both to one another and also the atrial cells surrounding the...
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Article
α1-Adrenoceptor agonists and IGF-1, myocardial hypertrophic factors, regulate the Kv1.5 K+ channel expression differentially in cultured newborn rat ventricular cells
Interest has arisen concerning the importance of α-adrenergic function and insulin-like growth factor-1 (IGF-1) in cardiac remodelling. The hypothesis that these two factors may underlie the regulation of vol...
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Article
Deferoxamine reduces the reperfusion injury in isolated neonatal rabbit hearts after hypothermic preservation
The protective action of deferoxamine, an iron chelator, against reperfusion injury following hypothermic preservation was investigated in the Langendorff-perfused hearts of neonatal rabbits. Left ventricular ...
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Article
Effects of combined use of class I antiarrhythmic agents on V max of guinea-pig ventricular muscles
The effects of the combined use of class-I antiarrhythmic drugs on the resting potentials (RP), amplitude of action potential (AMP), and V max of the action potential were inves...
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Article
Regional differences in the electrical activity of the rabbit sinus node
In order to study regional differences in membrane properties within the sinus node, we have investigated the electrical activity of small specimens of tissue (∼0.3 mm in diameter) that have been prepared from...
