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  1. Article

    Open Access

    Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice

    Calcineurin (Cn), a phosphatase important for synaptic plasticity and neuronal development, has been implicated in the etiology and pathophysiology of neuropsychiatric disorders, including schizophrenia, intel...

    Hideo Hagihara, Hirotaka Shoji, Mahomi Kuroiwa, Isabella A. Graef… in Molecular Brain (2022)

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  2. Article

    Open Access

    Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders

    Although the brains of patients with schizophrenia and bipolar disorder exhibit decreased brain pH relative to those of healthy controls upon postmortem examination, it remains controversial whether this findi...

    Hideo Hagihara, Vibeke S Catts, Yuta Katayama, Hirotaka Shoji… in Neuropsychopharmacology (2018)

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  3. No Access

    Article

    NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21

    Trisomy 21 results in Down's syndrome, but little is known about how a 1.5-fold increase in gene dosage produces the pleiotropic phenotypes of Down's syndrome. Here we report that two genes, DSCR1 and DYRK1A , li...

    Joseph R. Arron, Monte M. Winslow, Alberto Polleri, Ching-Pin Chang, Hai Wu… in Nature (2006)

  4. No Access

    Article

    L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons

    The molecular basis of learning and memory has been the object of several recent advances, which have focused attention on calcium-regulated pathways controlling transcription. One of the molecules implicated ...

    Isabella A. Graef, Paul G. Mermelstein, Kryn Stankunas, Joel R. Neilson… in Nature (1999)