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Article
Open AccessMetabolic profiles of saliva in male mouse models of chronic sleep disorders induced by psychophysiological stress
Disordered sleep is a global social problem and an established significant risk factor for psychological and metabolic diseases. We profiled non-targeted metabolites in saliva from mouse models of chronic slee...
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Article
Open AccessForebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice
Calcineurin (Cn), a phosphatase important for synaptic plasticity and neuronal development, has been implicated in the etiology and pathophysiology of neuropsychiatric disorders, including schizophrenia, intel...
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Article
Open AccessSimilarities of developmental gene expression changes in the brain between human and experimental animals: rhesus monkey, mouse, Zebrafish, and Drosophila
Experimental animals, such as non-human primates (NHPs), mice, Zebrafish, and Drosophila, are frequently employed as models to gain insights into human physiology and pathology. In developmental neuroscience a...
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Article
Open AccessPeripheral blood metabolome predicts mood change-related activity in mouse model of bipolar disorder
Bipolar disorder is a major mental illness characterized by severe swings in mood and activity levels which occur with variable amplitude and frequency. Attempts have been made to identify mood states and biol...
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Article
Open AccessExpression of progenitor cell/immature neuron markers does not present definitive evidence for adult neurogenesis
It is agreed upon that adult hippocampal neurogenesis (AHN) occurs in the dentate gyrus (DG) in rodents. However, the existence of AHN in humans, particularly in elderly individuals, remains to be determined. ...
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Article
Open AccessFluoxetine-induced dematuration of hippocampal neurons and adult cortical neurogenesis in the common marmoset
The selective serotonin reuptake inhibitor fluoxetine (FLX) is widely used to treat depression and anxiety disorders. Chronic FLX treatment reportedly induces cellular responses in the brain, including increas...
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Article
Open AccessAuthor Correction: Transcriptomic immaturity inducible by neural hyperexcitation is shared by multiple neuropsychiatric disorders
In the original published version of this article, Supplementary Data 1 reported gene expression fold changes incorrectly. The original supplementary file reported all fold changes as raw values, whereas the m...
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Article
Open AccessTranscriptomic immaturity inducible by neural hyperexcitation is shared by multiple neuropsychiatric disorders
Biomarkers are needed to improve the diagnosis of neuropsychiatric disorders, which are often associated to excitatory/inhibitory imbalances in neural transmission and abnormal maturation. Here, we characteriz...
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Article
Open AccessImmature-like molecular expression patterns in the hippocampus of a mouse model of dementia with Lewy body-linked mutant β-synuclein
Maturation abnormalities of the brain cells have been suggested in several neuropsychiatric disorders, including schizophrenia, bipolar disorder, autism spectrum disorders, and epilepsy. In this study, we exam...
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Article
Open AccessDecreased Brain pH as a Shared Endophenotype of Psychiatric Disorders
Although the brains of patients with schizophrenia and bipolar disorder exhibit decreased brain pH relative to those of healthy controls upon postmortem examination, it remains controversial whether this findi...
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Article
Open AccessImmature morphological properties in subcellular-scale structures in the dentate gyrus of Schnurri-2 knockout mice: a model for schizophrenia and intellectual disability
Accumulating evidence suggests that subcellular-scale structures such as dendritic spine and mitochondria may be involved in the pathogenesis/pathophysiology of schizophrenia and intellectual disability. Previ...
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Article
Open AccessTranscriptomic immaturity of the hippocampus and prefrontal cortex in patients with alcoholism
Alcoholism, which is defined as the recurring harmful use of alcohol despite its negative consequences, has a lifetime prevalence of 17.8%. Previous studies have shown that chronic alcohol consumption disrupts...
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Article
Open AccessTranscriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia
Schizophrenia, a severe psychiatric disorder, has a lifetime prevalence of 1%. The exact mechanisms underlying this disorder remain unknown, though theories abound. Recent studies suggest that particular cell ...
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Article
Open AccessDeficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia
Schnurri-2 (Shn-2), an nuclear factor-κB site-binding protein, tightly binds to the enhancers of major histocompatibility complex class I genes and inflammatory cytokines, which have been shown to harbor common v...
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Article
Open AccessExpression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus
New granule cells are continuously generated in the dentate gyrus of the adult hippocampus. During granule cell maturation, the mechanisms that differentiate new cells not only describe the degree of cell diff...
