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Role of MSK1 in the Induction of NF-κB by the Chemokine CX3CL1 in Microglial Cells

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  1. Article

    Open Access

    α-Synuclein Induces the GSK-3-Mediated Phosphorylation and Degradation of NURR1 and Loss of Dopaminergic Hallmarks

    In Parkinson’s disease, the dysfunction of the dopaminergic nigrostriatal tract involves the loss of function of dopaminergic neurons of the substantia nigra pars compacta followed by death of these neurons. T...

    Ángel Juan García-Yagüe, Isabel Lastres-Becker, Leonidas Stefanis… in Molecular Neurobiology (2021)

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  2. Article

    Open Access

    NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling

    The transcription factor NRF2 is a master regulator of cellular antioxidant and detoxification responses, but it also regulates other processes such as autophagy and pluripotency. In human embryonic stem cells...

    Ana Martin-Hurtado, Raquel Martin-Morales, Natalia Robledinos-Antón… in Scientific Reports (2019)

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  3. Article

    Open Access

    New alternative splicing variants of the ATXN2 transcript

    Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant disorder with progressive degeneration of cerebellar Purkinje cells and selective loss of neurons in the brainstem. This neurodegenerative disorder...

    Isabel Lastres-Becker, David Nonis, Joachim Nowock… in Neurological Research and Practice (2019)

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  4. Article

    Open Access

    Ataxin-2 Modulates the Levels of Grb2 and Src but Not Ras Signaling

    Ataxin-2 (ATXN2) is implicated mainly in mRNA processing. Some ATXN2 associates with receptor tyrosine kinases (RTK), inhibiting their endocytic internalization through interaction of proline-rich domains (PRD...

    Jessica Drost, David Nonis, Florian Eich, Oliver Leske… in Journal of Molecular Neuroscience (2013)

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