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Open AccessAn old model with new insights: endogenous retroviruses drive the evolvement toward ASD susceptibility and hijack transcription machinery during development
The BTBR T+Itpr3tf/J (BTBR/J) strain is one of the most valid models of idiopathic autism, serving as a potent forward genetics tool to dissect the complexity of autism. We found that a sister strain with an inta...
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Open AccessSex-linked markers in an Australian frog Platyplectrum ornatum (Limnodynastidae) with a small genome and homomorphic sex chromosomes
Amphibians have highly diverse sex-determining modes leading to a notable interest in vertebrate sex determination and sex chromosome evolution. The identification of sex-determining systems in amphibians, how...
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Publisher Correction: Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessA rapid rate of sex-chromosome turnover and non-random transitions in true frogs
The canonical model of sex-chromosome evolution predicts that, as recombination is suppressed along sex chromosomes, gametologs will progressively differentiate, eventually becoming heteromorphic. However, the...
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Correction to: Cell dynamics during differentiation therapy with all-trans retinoic acid in acute promyelocytic leukemia
In the original publication of the article, Table 2 was published incorrectly. The column names were swapped under the column heading “Prom (%)”. The correct column names are PB and BM.
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Open AccessGenetic map** of a male factor subfertility locus on mouse chromosome 4
Male reproductive anomalies are widely distributed among mammals, and male factors are estimated to contribute to approximately 50% of cases of human infertility. The B10.M/Sgn (B10.M) mouse strain exhibits tw...
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Open AccessA portion of expanded granular lymphocytes cause pure white cell aplasia?
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Open AccessDe novo acute lymphoblastic leukemia-like disease of high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: a case report and literature review
B-cell lymphomas harboring the 8q24/MYC plus 18q21/BCL2 translocations are now referred to as high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-MBR). Although HGBL-MBR is frequently fo...
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Open AccessThe parathyroid hormone regulates skin tumour susceptibility in mice
Using a forward genetics approach to map loci in a mouse skin cancer model, we previously identified a genetic locus, Skin tumour modifier of MSM 1 (Stmm1) on chromosome 7, conferring strong tumour resistance. Su...
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Open AccessPhylogeography reveals an ancient cryptic radiation in East-Asian tree frogs (Hyla japonica group) and complex relationships between continental and island lineages
In contrast to the Western Palearctic and Nearctic biogeographic regions, the phylogeography of Eastern-Palearctic terrestrial vertebrates has received relatively little attention. In East Asia, tectonic event...
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Open AccessIdentification of mutations through dominant screening for obesity using C57BL/6 substrains
The discovery of leptin substantiated the usefulness of a forward genetic approach in elucidating the molecular network regulating energy metabolism. However, no successful dominant screening for obesity has b...
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Open AccessKDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR
KDEL receptors are responsible for retrotransporting endoplasmic reticulum (ER) chaperones from the Golgi complex to the ER. Here we describe a role for KDEL receptor 1 (KDELR1) that involves the regulation of...
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Open AccessEffects of background mutations and single nucleotide polymorphisms (SNPs) on the Disc1 L100P behavioral phenotype associated with schizophrenia in mice
Disrupted-in-schizophrenia 1 (DISC1) is a promising candidate susceptibility gene for psychiatric disorders, including schizophrenia, bipolar disorder and major depression. Several previous studies reported th...
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Open AccessThe evolution of mitochondrial genomes in modern frogs (Neobatrachia): nonadaptive evolution of mitochondrial genome reorganization
Although mitochondrial (mt) gene order is highly conserved among vertebrates, widespread gene rearrangements occur in anurans, especially in neobatrachians. Protein coding genes in the mitogenome experience ad...
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Open AccessQTL on mouse chromosomes 1 and 4 causing sperm-head morphological abnormality and male subfertility
The B10.M mouse strain represents a model for male subfertility as it produces a significantly low number of offspring. The only known male reproductive phenotype of this strain is its high frequency of sperm-...
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Independent degeneration of W and Y sex chromosomes in frog Rana rugosa
The frog Rana rugosa uniquely possesses two different sex-determining systems of XX/XY and ZZ/ZW, separately in the geographic populations. The sex chromosomes of both types share the same origin at chromosome 7,...
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Open AccessPrimary splenic diffuse large B-cell lymphoma manifesting in red pulp
We evaluated six cases of diffuse large B-cell lymphoma (DLBCL) involving the red pulp of the spleen. All had B symptoms and an aggressive clinical course. The lymphoma cells proliferated diffusely and non-coh...
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Open AccessDisentangling genetic vs. environmental causes of sex determination in the common frog, Rana temporaria
Understanding of sex ratio dynamics in a given species requires understanding its sex determination system, as well as access for reliable tools for sex identification at different life stages. As in the case ...