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    Article

    The sinking platform test: a novel paradigm to measure persistence in animal models

    Persistence is the propensity to maintain goal-directed actions despite adversities. While this temperamental trait is crucial to mitigate depression risk, its neurobiological foundations remain elusive. Devel...

    Gabriele Floris, Sean C. Godar, Giulia Braccagni… in Neuropsychopharmacology (2024)

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    Article

    Maternal choline supplementation ameliorates Alzheimer’s disease pathology by reducing brain homocysteine levels across multiple generations

    The lack of effective treatments for Alzheimer’s disease (AD) is alarming, considering the number of people currently affected by this disorder and the projected increase over the next few decades. Elevated ho...

    Ramon Velazquez, Eric Ferreira, Wendy Winslow, Nikhil Dave… in Molecular Psychiatry (2020)

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    Article

    Necroptosis activation in Alzheimer's disease

    The mechanisms underpinning neuronal death in Alzheimer's disease (AD) remain unclear. Caccamo and colleagues show that necroptosis contributes to neurodegeneration in AD. Blocking necroptosis reduced neuronal...

    Antonella Caccamo, Caterina Branca, Ignazio S Piras, Eric Ferreira… in Nature Neuroscience (2017)