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Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis
Metastasis is the leading cause of cancer-related deaths and myeloid cells are critical in the metastatic microenvironment. Here, we explore the implications of reprogramming pre-metastatic niche myeloid cells...
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Open AccessThe induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression
Despite the remarkable success of immunotherapy in many types of cancer, pancreatic ductal adenocarcinoma has yet to benefit. Innate immune cells are critical to anti-tumor immunosurveillance and recent studie...
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Open AccessHigh-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
High-fat diet (HFD) decreases insulin sensitivity. How high-fat diet causes insulin resistance is largely unknown. Here, we show that lean mice become insulin resistant after being administered exosomes isolat...
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Open AccessEnhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway
The importance of gut microbiota in human health and pathophysiology is undisputable. Despite the abundance of metagenomics data, the functional dynamics of gut microbiota in human health and disease remain el...
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Open AccessArrowtail RNA for Ligand Display on Ginger Exosome-like Nanovesicles to Systemic Deliver siRNA for Cancer Suppression
Exosomes have shown increasing potential as delivery vesicles for therapy, but challenges like cost/yield, drug payload, and targeting specificity still exist. Plant derived exosome-like nanoparticles have bee...
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Open AccessMicrobiota-activated CD103+ DCs stemming from microbiota adaptation specifically drive γδT17 proliferation and activation
IL-17-producing γδT cells (γδT17) promote autoinflammatory diseases and cancers. Yet, γδT17 peripheral regulation has not been thoroughly explored especially in the context of microbiota-host interaction. The ...
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Open AccessMVP-mediated exosomal sorting of miR-193a promotes colon cancer progression
Exosomes are emerging mediators of intercellular communication; whether the release of exosomes has an effect on the exosome donor cells in addition to the recipient cells has not been investigated to any exte...
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Article
Open AccessCorrection: Corrigendum: Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids
Nature Communications 4: Article number: 1867 (2013); Published: 21 May 2013; Updated: 20 April 2016 The financial support for this Article was not fully acknowledged. The Acknowledgements should have included...
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Correction: Corrigendum: Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis
Nature Communications 6: Article number: 6956 (2015); Published 24 April 2015; Updated 11 April 2016 The financial support for this Article was not fully acknowledged. The Acknowledgements should have included...
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Correction: Corrigendum: Differential developmental requirement and peripheral regulation for dermal Vγ4 and Vγ6T17 cells in health and inflammation
Nature Communications 5: Article number: 3986 (2014); Published 9 June 2014; Updated 11 April 2016 The financial support for this Article was not fully acknowledged. The Acknowledgements should have included t...
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Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis
Gut-associated inflammation plays a crucial role in the progression of colon cancer. Here, we identify a novel pathogen–host interaction that promotes gut inflammation and the development of colon cancer. We f...
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Differential developmental requirement and peripheral regulation for dermal Vγ4 and Vγ6T17 cells in health and inflammation
Dermal IL-17-producing γδT cells have a critical role in skin inflammation. However, their development and peripheral regulation have not been fully elucidated. Here we demonstrate that dermal γδT cells develo...
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Open AccessExosomes: an overview of biogenesis, composition and role in ovarian cancer
Exosomes are tiny membrane-bound vesicles that are over produced by most proliferating cell types during normal and pathological states. Their levels are up-regulated during pregnancy and disease states such a...
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Article
Integrin CD11b negatively regulates BCR signalling to maintain autoreactive B cell tolerance
A variant of the integrin-α-M (CD11b) gene has been linked to the pathogenesis of systemic lupus erythematosus. However, how this genotype results in the lupus phenotype is not fully understood. Here we show that...
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Correction: Corrigendum: Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids
Nature Communications 4: Article number: 1867 (2013); Published: 21 May 2013; Updated: 6 September 2013. The authors inadvertently omitted Lifeng Zhang, who analysed data presented in this Article, from the au...
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Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids
Although the use of nanotechnology for the delivery of a wide range of medical treatments has potential to reduce adverse effects associated with drug therapy, tissue-specific delivery remains challenging. Her...
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Book
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The Role of Tumor Exosomes in Tumorigenicity
Tumor growth and metastasis is dependent on a complex interplay between the tumor cells and the tumor stroma as well as tumor-tumor interaction. This communication occurs through direct interaction, secreted f...
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The Effects of Exosomes and Related Vesicles on Cancer Development, Progression, and Dissemination
Exosomes are small bilayer-membrane-bound nanoparticles that are released from normal, diseased, and neoplastic cells and are present in blood and other bodily fluids. Exosomes contain a variety of signal mole...
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Article
Regulation of apoptosis proteins in cancer cells by ubiquitin
Ubiquitin inhibitors act at many levels to enhance apoptosis signaling. For TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis signaling, there are at least five mechanisms by which apoptosis are...
