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  1. No Access

    Article

    Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis

    Metastasis is the leading cause of cancer-related deaths and myeloid cells are critical in the metastatic microenvironment. Here, we explore the implications of reprogramming pre-metastatic niche myeloid cells...

    Chuanlin Ding, Rejeena Shrestha, **aojuan Zhu, Anne E. Geller… in Nature Immunology (2023)

  2. Article

    Open Access

    The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression

    Despite the remarkable success of immunotherapy in many types of cancer, pancreatic ductal adenocarcinoma has yet to benefit. Innate immune cells are critical to anti-tumor immunosurveillance and recent studie...

    Anne E. Geller, Rejeena Shrestha, Matthew R. Woeste, Haixun Guo… in Nature Communications (2022)

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  3. Article

    Correction: Corrigendum: Differential developmental requirement and peripheral regulation for dermal Vγ4 and Vγ6T17 cells in health and inflammation

    Nature Communications 5: Article number: 3986 (2014); Published 9 June 2014; Updated 11 April 2016 The financial support for this Article was not fully acknowledged. The Acknowledgements should have included t...

    Yihua Cai, Feng Xue, Chris Fleming, Jie Yang, Chuanlin Ding… in Nature Communications (2016)

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  4. No Access

    Article

    Differential developmental requirement and peripheral regulation for dermal Vγ4 and Vγ6T17 cells in health and inflammation

    Dermal IL-17-producing γδT cells have a critical role in skin inflammation. However, their development and peripheral regulation have not been fully elucidated. Here we demonstrate that dermal γδT cells develo...

    Yihua Cai, Feng Xue, Chris Fleming, Jie Yang, Chuanlin Ding… in Nature Communications (2014)

  5. No Access

    Article

    Integrin CD11b negatively regulates BCR signalling to maintain autoreactive B cell tolerance

    A variant of the integrin-α-M (CD11b) gene has been linked to the pathogenesis of systemic lupus erythematosus. However, how this genotype results in the lupus phenotype is not fully understood. Here we show that...

    Chuanlin Ding, Yunfeng Ma, **ngguo Chen, Min Liu, Yihua Cai… in Nature Communications (2013)

  6. No Access

    Article

    Regulation of autoreactive B cells: checkpoints and activation

    It has become clear that the autoreactive B cells are a part of the normal naïve B cell repertoire in the periphery, despite the fact that they undergo a series of checkpoints, which include receptor editing (...

    Chuanlin Ding, Jun Yan in Archivum Immunologiae et Therapiae Experimentalis (2007)