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Article
A comparative study on hemostasis effect of different application methods and time of tranexamic acid in total hip arthroplasty
To analyze the hemostatic effect of different application methods and time of tranexamic acid (TXA) on primary unilateral total hip arthroplasty.
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Article
Disruption of cholangiocyte-B cell crosstalk by blocking the CXCL12-CXCR4 axis alleviates liver fibrosis
B cells can promote liver fibrosis, but the mechanism of B cell infiltration and therapy against culprit B cells are lacking. We postulated that the disruption of cholangiocyte-B-cell crosstalk could attenuate...
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Article
Open AccessMTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis
Human MutT Homolog 1 (MTH1) is a nucleotide pool sanitization enzyme that hydrolyzes oxidized nucleotides to prevent their mis-incorporation into DNA under oxidative stress. Expression and functional roles of ...
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Article
Open AccessAtypical cholangiocytes derived from hepatocyte-cholangiocyte transdifferentiation mediated by COX-2: a kind of misguided liver regeneration
Hepatocyte-cholangiocyte transdifferentiation (HCT) is a potential origin of proliferating cholangiocytes in liver regeneration after chronic injury. This study aimed to determine HCT after chronic liver injur...
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Article
Open AccessCorrection: Celecoxib and octreotide synergistically ameliorate portal hypertension via inhibition of angiogenesis in cirrhotic rats
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Article
Therapeutic exosomes loaded with SERPINA5 attenuated endometrial cancer cell migration via the integrin β1/FAK signaling pathway
Metastasis is still the major cause of endometrial cancer (EC)-related death. Because of their biological function and regenerative properties, exosomes have been applied to therapeutic regimens. SERPINA5 expr...
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Article
The effectiveness of travel restriction measures in alleviating the COVID-19 epidemic: evidence from Shenzhen, China
With the expansion of the global novel coronavirus disease (COVID-19) pandemic, unprecedented interventions have been widely implemented in many countries, including China. In view of this scenario, this resea...
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Article
Open AccessDoes Monitoring Total and Free Polymyxin B1 Plasma Concentrations Predict Polymyxin B-Induced Nephrotoxicity? A Retrospective Study in Critically Ill Patients
The correlation between total and free polymyxin B (PMB including PMB1 and PMB2) exposure in vivo and acute kidney injury (AKI) remains obscure. This study explores the relationships between plasma exposure of...
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Article
Physical Properties, Pore-Throat Structure, Fractal Characteristics and Their Effects on the Gas-Bearing Capacity of Tight Sandstone: A Case Study from the Northern Tianhuan Depression, Ordos Basin, China
In this study, various testing methods were used to analyze the mineral characteristics, reservoir storage types and pore-throat network characteristics of the Permian tight sandstone in the Upper Paleozoic of...
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Article
Open AccessAuthor Correction: Targeting inhibition of extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) suppresses growth and angiogenesis of gastric cancer
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Article
Detection of multiple lesions of gastrointestinal tract for endoscopy using artificial intelligence model: a pilot study
This study was aimed to develop a computer-aided diagnosis (CAD) system with deep-learning technique and to validate its efficiency on detecting the four categories of lesions such as polyps, advanced cancer, ...
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Article
Adverse reactions to subcutaneous immunotherapy in patients with allergic rhinitis, a real-world study
The efficacy of subcutaneous immunotherapy (SCIT) for allergic rhinitis (AR) have been proven but application is still limited by concerns about the safety. The aims of this study were to investigate the incid...
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Article
Open AccessDimethyl fumarate inhibits antibody-induced platelet destruction in immune thrombocytopenia mouse
Immune thrombocytopenia (ITP) is an autoimmune disease characterized as a low platelet count resulting from immune-mediated platelet destruction. Dimethyl fumarate (DMF) is widely applied for the treatment of ...
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Article
Plasma exosomes from endometrial cancer patients contain LGALS3BP to promote endometrial cancer progression
Endometrial cancer (EC) is a common gynaecological cancer worldwide. Exosomes, secreted by living cells and detected in various body fluids, can exchange information between organs and compartments to affect c...
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Article
Compromised Ileal Mucus Barrier Due to Impaired Epithelial Homeostasis Caused by Notch1 Signaling in Cirrhotic Rats
In liver cirrhosis, intestinal mucus barrier is rarely studied.
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Article
Open AccessThe impacts of acid suppression on duodenal microbiota during the early phase of severe acute pancreatitis
Duodenal dysbiosis may be potential infection risks in patients with severe acute pancreatitis (SAP). Acid-suppression drugs (ACDs) are widely used in SAP patients in Asian countries. However, the impact of AC...
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Article
Tacrolimus ameliorates thrombocytopenia in an ITP mouse model
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by lower platelet count resulting from immune cells-mediated platelet clearance. Tacrolimus is an immunosuppressive agent which selectively ...
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Article
High expression of long non-coding RNA Linc-A associates with poor survival in patients with colorectal cancer
Long intergenic non-coding RNA for kinase activation (Linc-A) has been reported to enhance the occurrence and progression of breast cancer. Nevertheless, whether Linc-A is related to the tumorigenesis of color...
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Article
Open AccessAutocrine motility factor promotes endometrial cancer progression by targeting GPER-1
Autocrine motility factor (AMF) is a critical factor regulating aggressiveness of endometrial cancer (EC). Multiple pieces of evidence indicate that it is through G protein coupled estrogen receptor (GPER) sig...
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Article
Theoretical realization of three-dimensional nanolattice structure fabrication based on high-order waveguide-mode interference and sample rotation
A theoretical method of using high-order waveguide-mode interference combined with sample rotation is proposed to fabricate different kinds of three-dimensional nanolattice structures. The lithography sample i...
