807 Result(s)
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Hua **a
Biomedicine
Oncology
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Article
Chronic changes in brain Mg2+ concentration after forebrain ischemia in the rat
Brain Mg2+ ion concentrations, [Mg2+], were evaluated in three groups of animals subjected to either 8 minutes (n=10), or 12 minutes (n=10) of near-complete forebrain ischemia, or sham operation (n=10), from thei...
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Chapter and Conference Paper
Changes in Protein Expression During Oval Cell Proliferation in the Liver
Two-dimensional Polyacrylamide gel electrophoresis (2DE) is a powerful technique for separation of proteins. This technology can now be used for analysis of protein expression and variation, and for identifica...
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Article
Involvement of heparan sulfate and related molecules in sequestration and growth promoting activity of fibroblast growth factor
Heparan sulfate proteoglycans (HSPGs) are ubiquitous macromolecules associated with the cell surface and extracellular matrix (ECM) of a wide range of cells of vertebrate and invertebrate tissues [1,2]. The ba...
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Chapter and Conference Paper
Characterization of Antioxidative Peptides from Soybean Proteins
Protease hydrolyses of various proteins yielded antioxidative activity against the peroxidation of linoleic acid. From the hydrolysate of a soybean protein, six antioxidative peptides were isolated by size exc...
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Article
Zinc ligand-disrupted recombinant human Endostatin: Potent inhibition of tumor growth, safety and pharmacokinetic profile
Endostatin, a potent endogenous inhibitor of angiogenesis, inhibits the growth of primary tumors without induction of acquired drug resistance in mice. We report that a soluble recombinant human (rh) Endostati...
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Article
Transcriptional profiling of human microvascular endothelial cells in the proliferative and quiescent state using cDNA arrays
Endothelial cells are known to be a rich source of transcriptional gene expression. Recent technological advances now permit the detailed profiling of mRNA expression using arrays of known cDNAs on blots. We h...
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Article
Phosphoinositide 3 kinase is critical for survival, mitogenesis and migration but not for differentiation of endothelial cells
Angiogenesis involves endothelial cell invasion and migration into the surrounding tissue where cells differentiate, to form new lumen-containing vessels. We have investigated the role of phosphoinositide 3-ki...
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Article
Alcohol Consumption and Breast Cancer among Black and White Women in North Carolina (United States)
Objective: The purpose of this study was to investigate the effects of alcohol consumption on breast cancer risk in black and white women.
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Article
Neuropilin is a Mediator of Angiogenesis
Neuropilin is both a receptor for semaphorins, which are mediators of neuronal guidance, and for VEGF, an angiogenesis factor. While the function of neuropilin in the nervous system has been characterized, its...
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Article
Open AccessP53 germline mutations in childhood cancers and cancer risk for carrier individuals
The family history of cancer in children treated for a solid malignant tumour in the Paediatric Oncology Department at Institute Gustave-Roussy, has been investigated. In order to determine the role of germlin...
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Article
GSTP1 polymorphisms and gastric cancer in a high-risk Chinese population
Objectives: In a population-based case–control study in Yangzhong, China, we investigated the relationship between genetic polymorphisms of GSTP1 and susceptibility to gastric cancer and its premalignant lesion,...
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Article
Open AccessImmunodetection of nmt55/p54nrbisoforms in human breast cancer
We previously identified and characterized a novel 55 kDa nuclear protein, termed nmt55/p54nrb, whose expression was decreased in a subset of human breast tumors. The objective of this study was to determine if t...
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Article
Open AccessExpression of p53, inducible nitric oxide synthase and vascular endothelial growth factor in gastric precancerous and cancerous lesions: correlation with clinical features
The growth and metastasis of tumors depend on the development of an adequate blood supply via angiogenesis. Recent studies indicate that the inducible nitric oxide synthase (iNOS), vascular endothelial growth ...
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Article
Establishment of fluorescent lung carcinoma metastasis model and its real-time microscopic detection in SCID mice
Lung cancer is the most prevalent malignant tumor in the world. Metastasis of the disease causes death in lung cancer patients. Recent study has shown that multiple cascades of gene defects occur in lung cance...
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Article
Open AccessA subgroup of microsatellite stable colorectal cancers has elevated mutation rates and different responses to alkylating and oxidising agents
An early step in the carcinogenesis of hereditary non-polyposis colorectal cancer (HNPCC) and some sporadic colorectal cancers (CRCs) is the acquisition of a ‘mutator phenotype’ resulting from defects in DNA m...
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Article
Tumor cell invasion and survival in head and neck cancer
Squamous cell carcinoma (SCC) is the primary tumor type in head and neck cancer. Typically, these tumor cells show persistent invasion that frequently leads to local recurrence and distant lymphatic metastasis...
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Article
Open AccessStromal cell derived factor-1: its influence on invasiveness and migration of breast cancer cells in vitro, and its association with prognosis and survival in human breast cancer
Stromal cell-derived factor (SDF)-1 (CXC chemokine ligand-12) is a member of the CXC subfamily of chemokines, which, through its cognate receptor (CXC chemokine receptor [CXCR]4), plays an important role in ch...
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Article
Targeting STAT3 affects melanoma on multiple fronts
As a point of convergence for numerous oncogenic signaling pathways, STAT3 is constitutively-activated at 50 to 90% frequency in diverse human cancers, including melanoma. A critical role of STAT3 in tumor cel...
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Article
Open AccessBreast tumor copy number aberration phenotypes and genomic instability
Genomic DNA copy number aberrations are frequent in solid tumors, although the underlying causes of chromosomal instability in tumors remain obscure. Genes likely to have genomic instability phenotypes when mu...
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Article
Open AccessTrends in incidence and mortality of nasopharyngeal carcinoma over a 20–25 year period (1978/1983–2002) in Sihui and Cangwu counties in southern China
Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world but is common in southern China. A recent report from the Hong Kong Cancer Registry, a high-risk area for NPC in southern China, s...
