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Article
A predictive model of inflammatory markers and patient-reported symptoms for cachexia in newly diagnosed pancreatic cancer patients
Cachexia is a frequent manifestation of pancreatic cancer, can limit a patient’s ability to take chemotherapy, and is associated with shortened survival. We developed a model to predict the early onset of cach...
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Article
Open AccessChronic inflammation initiates multiple forms of K-Ras-independent mouse pancreatic cancer in the absence of TP53
Chronic inflammation (CI) is a risk factor for pancreatic cancer (PC) including the most common type, ductal adenocarcinoma (PDAC), but its role and the mechanisms involved are unclear. To investigate the role...
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Article
Rain drop size variation with cloud base height at a tropical location
The inter-relation of rain drop size distribution with cloud base height has been investigated at a tropical location, Kolkata (22°34′N, 88°22′E). The study focuses the association of rain drop size distributi...
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Article
p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells
Pancreatic cancer is one of the most lethal malignancies, with virtually all patients eventually succumbing to their disease. Mutations in p53 have been documented in >50% of pancreatic cancers. Owing to the h...
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Article
Open AccessHuman genome meeting 2016
O1 The metabolomics approach to autism: identification of biomarkers for early detection of autism spectrum disorder
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Article
Open AccessValidation of histomolecular classification utilizing histological subtype, MUC1, and CDX2 for prognostication of resected ampullary adenocarcinoma
Outcomes for ampullary adenocarcinomas are heterogeneous, and numerous methods of categorisation exist. A histomolecular phenotype based on histology, caudal-type homeodomain transcription factor 2 (CDX2) stai...
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Article
Differential in vivo tumorigenicity of diverse KRAS mutations in vertebrate pancreas: A comprehensive survey
Somatic activation of the KRAS proto-oncogene is evident in almost all pancreatic cancers, and appears to represent an initiating event. These mutations occur primarily at codon 12 and less frequently at codons 1...
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Article
Effects on stratospheric moistening by rates of change of aerosol optical depth and ozone due to solar activity in extra-tropics
The solar-induced changes in ozone and aerosol optical depth have relative effects on stratospheric moistening at upper troposphere/lower stratosphere region. Wavelet-based multi-scale principal component anal...
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Article
Next-generation sequencing of endoscopic biopsies identifies ARID1A as a tumor-suppressor gene in Barrett’s esophagus
The incidence of Barrett’s esophagus (BE)-associated esophageal adenocarcinoma (EAC) is increasing. Next-generation sequencing (NGS) provides an unprecedented opportunity to uncover genomic alterations during ...
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Article
Single nucleotide polymorphisms in caprine calpastatin gene
The calpains and calpastatin (CAST) make up a major cytosolic proteolytic system, the calpain-calpastatin system, found in mammalian tissues. The relative levels of the components of the calpain-calpastatin sy...
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Article
Differentiation of four indian aboriginal cattle populations revealed by SIR markers
Cattle are the most important livestock in India and play a pivotal role in agrarian economy. There are 34 recognized breeds of cattle and number of unexplored lesser known populations. The present study is a ...
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Article
Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer
During tumor initiation, oncogene-induced senescence (OIS) is proposed to limit the progression of preneoplasms to invasive carcinoma unless circumvented by the acquisition of certain tumor suppressor mutation...
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Article
Sharp depletion of attenuation of 22.235 GHz associated with Nor’wester over Kolkata, India and possible method of forecasting Nor’wester
The sharp depletion of attenuation of 22.235 GHz signal before the onset of Nor’wester over Kolkata, India is observed and possible explanation of such type of variation is presented. It is concluded that this...
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Chapter and Conference Paper
MicroRNA miR-155 is a biomarker of early pancreatic neoplasia
Intraductal papillary mucinous neoplasms (IPMN) are non-invasive precursor lesions of pancreatic cancer (PC), which originate in ductal cells and can be macroscopically identified. These lesions can be classif...
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Article
Congenital generalized lipodystrophy in an Indian patient with a novel mutation in BSCL2 gene
Congenital generalized lipodystrophy (CGL) is an autosomal recessive metabolic syndrome with involvement of multiple organs. Mutations in BSCL2 are known to be associated with a severe form of CGL and mental reta...
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Chapter and Conference Paper
Die Überexpression der onkogenen Kras-Mutation G12D im adulten Pankreas führt zur Entstehung von highgrade PanIN-Läsionen in Ela-CreERT2;LSL-KrasG12D-Mäusen
Background: Pancreatic ductal adenocarcinomas (PDA) typically arise from three different precursor lesion. Out of these, pancreatic intraepithelial neoplasias (PanINs) are best characterized at b...
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Chapter and Conference Paper
Aktivierung von Snail und Sonic Hedgehog bei neuroendokrinen Tumoren des Ileums
The transcription factor Snail represses E-cadherin and induces epithelial-mesenchymal transition (EMT), a process also exploited by invasive cancer cells. Aberrant Hedgehog (Hh) signaling was recently observe...
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Chapter
Pathology of Pancreatic Cancer
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Chapter and Conference Paper
Die Überexpression von Sonic Hedgehog führt zur epithelialen-mesenchymalen Transition im adulten Pankreas der Maus
The Hedgehog signaling pathway plays a central in carcinogenesis in tumors of endodermal origin, including pancreatic cancer. To directly determine the effect of sustained Hedgehog activity on mature mammalian...
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Chapter and Conference Paper
Hedgehog Signalweg Aktivierung während akuter Schädigung und Regeneration des exokrinen Pankreas
Unsere Ergebnisse zeigen erstmals, dass der Hh Signalweg während der akuten Gewebsschädigung des exokrinen Pankreas aktiviert wird. Dieser Prozess scheint ebenso eine wichtige Rolle in der Regenerationsphase z...
