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  1. Article

    Open Access

    Mechanoporation enables rapid and efficient radiolabeling of stem cells for PET imaging

    Regenerative medicine uses the patient own stem cells to regenerate damaged tissues. Molecular imaging techniques are commonly used to image the transplanted cells, either right after surgery or at a later tim...

    Kyung Oh Jung, Ashok Joseph Theruvath, Hossein Nejadnik, Anna Liu… in Scientific Reports (2022)

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  2. No Access

    Article

    Ferumoxytol Can Be Used for Quantitative Magnetic Particle Imaging of Transplanted Stem Cells

    To evaluate, if clinically translatable ferumoxytol nanoparticles can be used for in vivo detection and quantification of stem cell transplants with magnetic particle imaging (MPI).

    Hossein Nejadnik, Prachi Pandit, Olga Lenkov… in Molecular Imaging and Biology (2019)

  3. No Access

    Article

    Association of Tumor [18F]FDG Activity and Diffusion Restriction with Clinical Outcomes of Rhabdomyosarcomas

    To evaluate whether the extent of restricted diffusion and 2-deoxy-2-[18F] fluoro-d-glucose ([18F]FDG) uptake of pediatric rhabdomyosarcomas (RMS) on positron emission tomography (PET)/magnetic resonance (MR) ima...

    Arian Pourmehdi Lahiji, Tatianie Jackson, Hossein Nejadnik… in Molecular Imaging and Biology (2019)

  4. No Access

    Article

    Tumor Formation of Adult Stem Cell Transplants in Rodent Arthritic Joints

    While imaging matrix-associated stem cell transplants aimed for cartilage repair in a rodent arthritis model, we noticed that some transplants formed locally destructive tumors. The purpose of this study was t...

    Fanny Chapelin, Aman Khurana, Mohammad Moneeb… in Molecular Imaging and Biology (2019)

  5. Article

    Open Access

    Nanoparticle enhanced MRI can monitor macrophage response to CD47 mAb immunotherapy in osteosarcoma

    CD47 monoclonal antibodies (mAbs) activate tumor-associated macrophages (TAMs) in sarcomas to phagocytose and eliminate cancer cells. Though CD47 mAbs have entered clinical trials, diagnostic tests for monitor...

    Suchismita Mohanty, Ketan Yerneni, Johanna Lena Theruvath… in Cell Death & Disease (2019)

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  6. No Access

    Article

    Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

    Until now, the Food and Drug Administration (FDA)-approved iron supplement ferumoxytol and other iron oxide nanoparticles have been used for treating iron deficiency, as contrast agents for magnetic resonance ...

    Saeid Zanganeh, Gregor Hutter, Ryan Spitler, Olga Lenkov… in Nature Nanotechnology (2016)

  7. Article

    Open Access

    Macrophage phagocytosis alters the MRI signal of ferumoxytol-labeled mesenchymal stromal cells in cartilage defects

    Human mesenchymal stem cells (hMSCs) are a promising tool for cartilage regeneration in arthritic joints. hMSC labeling with iron oxide nanoparticles enables non-invasive in vivo monitoring of transplanted cells ...

    Hossein Nejadnik, Olga Lenkov, Florian Gassert, Deborah Fretwell… in Scientific Reports (2016)

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  8. Article

    Open Access

    Improved Approach for Chondrogenic Differentiation of Human Induced Pluripotent Stem Cells

    Human induced pluripotent stem cells (hiPSCs) have demonstrated great potential for hyaline cartilage regeneration. However, current approaches for chondrogenic differentiation of hiPSCs are complicated and in...

    Hossein Nejadnik, Sebastian Diecke, Olga D. Lenkov… in Stem Cell Reviews and Reports (2015)

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  9. No Access

    Protocol

    Magnetic Resonance Imaging and Tracking of Stem Cells

    To date, several stem cell labeling protocols have been developed, contributing to a fast growing and promising field of stem cell imaging by MRI (magnetic resonance imaging). Most of these methods utilize iro...

    Hossein Nejadnik, Rostislav Castillo… in Imaging and Tracking Stem Cells (2013)

  10. Article

    Engineering stem cells for treatment of osteochondral defects

    Hossein Nejadnik, Heike E. Daldrup-Link in Skeletal Radiology (2012)

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