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  1. No Access

    Chapter

    p53 Protein and Pathogenesis of Melanoma and Nonmelanoma Skin Cancer

    The p53 tumor suppressor gene and gene product are among the most diverse and complex molecules involved in cellular functions. Genetic alterations within the p53 gene have been shown to have a direct correlat...

    Cara L. Benjamin, Vladislava O. Melnikova… in Sunlight, Vitamin D and Skin Cancer (2008)

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    Chapter

    p53 Protein and Nonmelanoma Skin Cancer

    Skin cancer is the most common type of human cancer today, and its incidence has been increasing with an astonishing rate. It is estimated that about 70% of nonmelanoma skin cancers (NMSC) are induced by ultra...

    Vladislava O. Melnikova… in Molecular Mechanisms of Basal Cell and Squ… (2006)

  3. No Access

    Article

    Fate of UVB-induced p53 mutations in SKH-hr1 mouse skin after discontinuation of irradiation: relationship to skin cancer development

    Chronic exposure to ultraviolet (UV) radiation causes skin cancer in humans and mice. We have previously shown that in hairless SKH-hr1 mice, UVB-induced p53 mutations arise very early, well before tumor developm...

    Vladislava O Melnikova, Alessia Pacifico, Sergio Chimenti, Ketty Peris… in Oncogene (2005)

  4. No Access

    Article

    Genomic alterations in spontaneous and carcinogen-induced murine melanoma cell lines

    We have conducted an analysis of genetic alterations in spontaneous murine melanoma cell line B16F0 and its two metastatic clones, B16F1 and B16F10 and the carcinogen-induced murine melanoma cell lines CM519, CM3...

    Vladislava O Melnikova, Svetlana V Bolshakov, Christopher Walker… in Oncogene (2004)

  5. No Access

    Article

    Mutant p53 is constitutively phosphorylated at Serine 15 in UV-induced mouse skin tumors: involvement of ERK1/2 MAP kinase

    Upon DNA damage, phosphorylation and nuclear translocation of wild-type p53 tumor suppressor protein signals its functional activation. However, very little is known about phosphorylation and localization of m...

    Vladislava O Melnikova, Annette B Santamaria, Svetlana V Bolshakov… in Oncogene (2003)

  6. No Access

    Article

    Persistence of p53 mutations and resistance of keratinocytes to apoptosis are associated with the increased susceptibility of mice lacking the XPC gene to UV carcinogenesis

    Like xeroderma pigmentosum (XP) patients, transgenic mice lacking nucleotide excision repair (NER) genes such as XPA and XPC are extremely susceptible to ultraviolet (UV)-induced skin cancer. Because the p53 gene...

    Honnavara N Ananthaswamy, Allal Ouhtit, Randall L Evans, Alexander Gorny… in Oncogene (1999)

  7. No Access

    Article

    p53 protects against skin cancer induction by UV-B radiation

    To assess the role of the p53 tumor suppressor gene in skin carcinogenesis by UV radiation, mice constitutively lacking one or both copies of the functional p53 gene were compared to wild-type mice for their susc...

    Weidong Jiang, Honnavara N Ananthaswamy, H Konrad Muller, Margaret L Kripke in Oncogene (1999)

  8. No Access

    Article

    Sunlight and skin cancer: Inhibition of p53 mutations in UV-irradiated mouse skin by sunscreens

    UV-induced mutations in the p53 tumor suppressor gene play an essential role in skin cancer development. We report here that such mutations can be detected in UV-irradiated mouse skin months before the gross appe...

    Honnavara N. Ananthaswamy, Susan M. Loughlin, Patricia Cox… in Nature Medicine (1997)

  9. No Access

    Article

    Inhibition of colony formation in agarose of metastatic human breast carcinoma and melanoma cells by synthetic glycoamine analogs

    We studied the influence of 10 synthetic glycoamine analogs on colony formation in 0.3 and 0.9% agarose by metastatic human breast carcinoma (MDA-MB-435) and melanoma (TXM-13) cells. Nine synthetic analogs sig...

    Gennadi V. Glinsky, Valeri V. Mossine, Janet E. Price… in Clinical & Experimental Metastasis (1996)

  10. No Access

    Article

    Correlation between Ha-ras gene amplification and spontaneous metastasis in NIH 3T3 cells transfected with genomic DNA from human skin cancers

    Our previous studies have shown that DNA from some human skin cancers contained activated Ha-ras oncogenes capable of inducing tumorigenic transformation when introduced into NIH 3T3 cells by DNA-mediated gene tr...

    Honnavara N. Ananthaswamy, Janet E. Price… in Clinical & Experimental Metastasis (1989)