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Article
A novel pH-sensitive antibacterial bilayer film for intelligent packaging
Intelligent single-layer packaging is widely used in food monitoring and storage. However, most single-layer intelligent packaging has poor mechanical strength and water barrier properties. In this study, a b...
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Article
Evaluation of [99mTc]Tc-TTHMP as a SPECT imaging agent for skeletal system
TTHMP (triethylene-tetramine-hexamethylene-phosphonic acid) shows good bone-seeking ability in previous studies. In this research, [99mTc]Tc-TTHMP was prepared with the radiochemical yield of 98% and the possibl...
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Article
Comparative cytotoxicity of 177Lu on various lung cancer cells and in vivo targeting of 177Lu-labeled cetuximab
Differences in cellular radiosensitivity and the binding affinity of radiopharmaceuticals could directly affect the radiotherapeutic effects. In this study, we investigated the radionuclide (177Lu) induced radios...
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Article
Effective lutetium/ytterbium separation for no-carrier added lutetium-177 production
In order to realize no-carrier added lutetium-177 (177Lu) production through 176Yb(n, γ) 177Yb→ 177Lu process, effective separation of 177Lu from Yb target including lanthanide resin (LNR) and high performance li...
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Article
Protonation of Chelidamic Acid: Thermodynamic Analysis and Crystal Structure
Thermodynamics of the protonation of chelidamic acid (4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid) was studied using potentiometry and calorimetry in 0.1 mol·L− 1 NaClO4 solution at 298 K under standard press...
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Article
Preliminary evaluation and in vitro cytotoxicity studies of [131I]I-trastuzumab in HER2 expressing ovarian cancer cells
As trastuzumab is known to target the human epidermal growth factor receptor type (HER2), the potential of [131I]I-trastuzumab as a radioimmunotherapy agent was evaluated in vitro and in vivo for HER2-overexpress...
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Article
Black Phosphorus/Nanocarbons Constructing a Dual-Carbon Conductive Network for High-Performance Sodium-Ion Batteries
Black phosphorus has been recognized as a prospective candidate anode material for sodium-ion batteries (SIBs) due to its ultrahigh theoretical capacity of 2596 mA·h/g and high electric conductivity of ≈ 300 S...
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Article
In vitro and in vivo evaluation of a novel anti-EGFR antibody labeled with 89Zr and 177Lu
There is an urgent need to develop more specific targeted therapies for lung cancer treatment due to the its low survival rate. EGFR is a transmembrane tyrosine kinase protein that is overexpressed in lung can...
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Article
A novel method for preparation of SiC/SiO2 nanocables and photoluminescence performance study
Herein, a novel and catalyst-free method for preparation of SiC/SiO2 nanocables was proposed. SiC/SiO2 nanocables were successfully prepared from expanded graphite and rice husk ash via carbon thermal reduction. ...
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Article
89Zr and 177Lu labeling of anti-DR5 monoclonal antibody for colorectal cancer targeting PET-imaging and radiotherapy
Death receptor 5 (DR5) is overexpressed in many tumors. Combination of the anti-DR5 antibody with radionuclides such as lutetium-177 (177Lu) could enhance apoptosis and decrease the possibility of drug-induced re...
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Article
Solubility and Thermodynamic Properties of Sulfamethazine–Saccharin Cocrystal in Pure and Binary (Acetonitrile + 2-Propanol) Solvents
In this work, a new crystallization method was used to prepare two polymorphs of sulfamethazine–saccharin (SMT–SAC) cocrystal in bulk. The purity and crystal form of both polymorphs were confirmed by optical m...
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Article
Synergistic Effect of Cocamidopropyl Betaine and Sodium Lauroyl Sarcosinate
In this study, we investigated the synergistic effect of a zwitterionic surfactant (cocamidopropyl betaine) and amino acid surfactant (sodium lauroyl sarcosinate) by measurements of surface tension, rheologica...
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Article
Preparation and Physicochemical Properties of Catechin/β-cyclodextrin Inclusion Complex Nanoparticles
Nano-size catechin/β-cyclodextrin inclusion complex (CA/β-CD IC) with 1:1 molar ratio was obtained by cooling precipitation at 4 °C. Physicochemical properties of the CA/β-CD IC nanoparticles were characterize...
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Article
Genetic risk factors for autism-spectrum disorders: a systematic review based on systematic reviews and meta-analysis
Based on recent evidence, more than 200 susceptibility genes have been identified to be associated with autism until now. Correspondingly, cytogenetic abnormalities have been reported for almost every chromoso...
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Article
Paraffin/SiC as a Novel Composite Phase-Change Material for a Lithium-Ion Battery Thermal Management System
A lithium-ion battery thermal management system has always been a hot spot in the battery industry. In this study, a novel high-thermal-conductivity composite phase-change material (CPCM) made by paraffin wax ...
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Article
Open AccessMolecular detection and phylogenetic analyses of Wolbachia in natural populations of nine galling Aphid species
Wolbachia is one of the most abundant facultative intracellular symbionts in arthropods. It alters host biology in diverse ways, including the induction of reproductive manipulation, association of nutrient suppl...
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Article
Preparation and cellular-interaction investigation of 177Lu/FITC labeled NGR peptides
Aminopeptidase N (CD13) as the malignant cell surface marker is overexpressed on many tumor cells including lung cancer and the neovascular cell membranes. A tripeptide structure, Asn-Gly-Arg (NGR), can specif...
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Article
Complexation of 1,3-Diamino-2-hydroxypropane-N,N,N',N'-tetraacetic Acid (DHPTA) with Heavy Lanthanides (Tb3+, Ho3+, Lu3+) in Aqueous Solution
Thermodynamic equilibria of complexes of 1,3-diamino-2-hydroxypropane-N,N,N',N'-tetraacetic acid (DHPTA) with heavy lanthanides (Tb3+, Ho3+ and Lu3+) in aqueous solution have been investigated with potentiometry,...
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Article
131I-labeled PEG and folic acid co-functionalized graphene quantum dots for tumor-targeted imaging
In this study, we successfully synthesized polyethylene glycol (PEG) and folic acid (FA) co-functionalized graphene quantum dots (GQDs) to improve the biocompatibility and tumor-targeting ability of GQDs simul...
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Article
Comparative cell uptake study of FITC-/177Lu-labeled RM26 monomer, dimer and trimer on PC-3: improving binding affinity of gastrin releasing peptide receptor (GRPR) antagonist via bivalency/trivalency
The gastrin releasing peptide receptors (GRPRs) overexpress in various tumors, which provided the opportunity for GRPR targeted tumor radiological diagnosis and therapy. In recent reports, the GPPR antagonists...
