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Article
Open AccessDifferential CpG methylation at Nnat in the early establishment of beta cell heterogeneity
Beta cells within the pancreatic islet represent a heterogenous population wherein individual sub-groups of cells make distinct contributions to the overall control of insulin secretion. These include a subpop...
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Article
Open AccessLoss of H3K9 trimethylation alters chromosome compaction and transcription factor retention during mitosis
Recent studies have shown that repressive chromatin machinery, including DNA methyltransferases and polycomb repressor complexes, binds to chromosomes throughout mitosis and their depletion results in increase...
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Article
Open AccessSnapshots of actin and tubulin folding inside the TRiC chaperonin
The integrity of a cell’s proteome depends on correct folding of polypeptides by chaperonins. The chaperonin TCP-1 ring complex (TRiC) acts as obligate folder for >10% of cytosolic proteins, including he cytos...
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Article
Open AccessIndisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma
Neuroblastoma is the most common paediatric solid tumour and prognosis remains poor for high-risk cases despite the use of multimodal treatment. Analysis of public drug sensitivity data showed neuroblastoma li...
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Article
Open AccessSexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis
Variants close to the VPS13C/C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes in genome-wide association studies. While previous functional work has suggested roles for VPS13C and C2CD4A in...
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Article
Open AccessIdentifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction
Epigenetic information is transmitted from mother to daughter cells through mitosis. Here, to identify factors that might play a role in conveying epigenetic memory through cell division, we report on the isol...
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Article
Open AccessAspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern
AspH is an endoplasmic reticulum (ER) membrane-anchored 2-oxoglutarate oxygenase whose C-terminal oxygenase and tetratricopeptide repeat (TPR) domains present in the ER lumen. AspH catalyses hydroxylation of a...
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Article
FACT mediates cohesin function on chromatin
Cohesin is a regulator of genome architecture with roles in sister chromatid cohesion and chromosome compaction. The recruitment and mobility of cohesin complexes on DNA is restricted by nucleosomes. Here, we ...
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Chapter
Market Conditions, Mission Requirements and Operational Profiles
The present chapter deals with the modern ship design from the perspective of an experienced European ship design and engineering office, namely Elomatic Oy. When a shipowner sees the opportunity to expand his...
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Article
The influence of parameter estimation on the ARL of Shewhart type charts for time series
In this paper we discuss the behavior of the Shewhart residual chart and the modified Shewhart chart if the parameters of the underlying process are unknown and thus have to be estimated. We focus on the estim...
