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Article
Open AccessSignal peptide mimicry primes Sec61 for client-selective inhibition
Preventing the biogenesis of disease-relevant proteins is an attractive therapeutic strategy, but attempts to target essential protein biogenesis factors have been hampered by excessive toxicity. Here we descr...
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Article
Open AccessSnapshots of actin and tubulin folding inside the TRiC chaperonin
The integrity of a cell’s proteome depends on correct folding of polypeptides by chaperonins. The chaperonin TCP-1 ring complex (TRiC) acts as obligate folder for >10% of cytosolic proteins, including he cytos...
