-
Article
Open AccessDouble seismic zone and seismicity in the mantle wedge beneath the Ogasawara Islands identified by an ocean bottom seismometer observation
Around the Ogasawara Islands, only a few seismic stations in the area can be used to determine the hypocenters of regional earthquakes; thus, hypocenter location precision tends to be low. To more precisely de...
-
Article
A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine
Shiro Ikegawa and colleagues report the results of a genome-wide association study for ossification of the posterior longitudinal ligament of the spine in a Japanese cohort. They identify six new loci, three o...
-
Article
Open AccessSub-seafloor resistivity sensing using a vertical electrode configuration
There is growing interest in marine direct current (DC) resistivity methods for sub-seafloor exploration of a broad range of geophysical and geological targets. To address this, we have developed a new marine ...
-
Chapter
Microarray Analysis of Expression of Cell Death-Associated Genes in Spinal Cord Cells with Cyclic Tensile Strain
Previous studies have described alterations in gene expression following spinal cord injury, but this response to mechanical stimuli is difficult to investigate in vivo. Therefore, we have investigated the eff...
-
Chapter
Blockade of Interleukin-6 Effects on Cytokine Profiles and Macrophage Activation After Spinal Cord Injury in Mice
The objective of this study was to clarify the effects of a temporal blockade of IL-6/IL-6 receptor (IL-6R) engagement, using an anti-mouse IL-6R monoclonal antibody (MR16-1), on macrophage activation and the ...
-
Chapter
Transplantation of Mesenchymal Stem Cells Derived from Bone Marrow in the Injured Spinal Cord
The present study was designed to investigate the effects of mesenchymal stem cells (MSC) transplantation with a special focus on their effect on macrophage activation after SCI. The transplanted MSC migrated ...
-
Chapter
Morphological Changes in Anterior Horn Cells, Immunoreactivity to Neurotrophic Factors, and Neuronal Cell Death of Spinal Cord Lesions in the Spinal Hyperostotic Mouse (twy/twy) with Chronic Mechanical Cord Compression
We examined the morphology of spinal accessory motoneurons, immunoreactivity to brain-derived neurotrophic factor (BDNF) and neurotrophin (NT)-3, and reactive astrocytosis in 70 tiptoe-walking Yoshimura (twy/twy)...
-
Chapter
Clinical Significance of 3D-MRI/18F-FDG PET Fusion Imaging of Patients with Cervical Compressive Myelopathy
The present study was designed to evaluate the use of three-dimensional (3D)-MRI/18F-FDG PET fusion imaging to define intramedullary signal changes on MRIs and local glucose metabolic rate measured on 18F-FDG PET...
-
Chapter
Targeted Retrograde Gene Delivery into the Injured Spinal Cord Using Recombinant Adenovirus Vector Carrying Neurotrophic Factor Gene
We investigated the efficacy of retrograde gene delivery via the sternomastoid muscle of recombinant adenovirus vector (AdV) carrying brain-derived neurotrophic factor (BDNF) gene for the rescue of injured rat...
-
Article
The effects of adenoviral transfection of the keratinocyte growth factor gene on epidermal stem cells: An in vitro study
Epidermal stem cells (ESCs) are characterized as slowcycling, multi-potent, and self-renewing cells that not only maintain somatic homeostasis but also participate in tissue regeneration and repair. To examine...
-
Article
Dislocated intra-articular femoral head fracture associated with fracture-dislocation of the hip and acetabulum: report of 12 cases and technical notes on surgical intervention
This report describes case series of the femoral head fractures associated with fracture-dislocation of the hip joint to evaluate the mid- and long-term outcomes and to highlight the surgical technique of fixa...
-
Article
Open AccessChondroblastoma of the distal femur resected through a small fenestra via computed tomography navigation and endoscopy: a case report
Chondroblastoma is a benign bone tumor with a relatively high incidence in older children and adolescents during the period of active epiphyseal growth. It is generally regarded as a benign neoplasm, but somet...
-
Article
A genome-wide sib-pair linkage analysis of ossification of the posterior longitudinal ligament of the spine
Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common musculoskeletal disease among people after middle age. The OPLL presents with serious neurological abnormalities due to comp...
-
Article
Fracture of the acetabulum: a retrospective review of ninety-one patients treated at a single institution
Acetabular fracture result in fairly good outcome after the anatomic reduction in the displaced fracture fragments and damaged joint structure, but some patients will inevitably suffer from hip joint problems ...
-
Article
Open AccessCutaneous squamous cell carcinoma (SCC) arising in stump of amputated finger in a patient with resected glossal SCC
Cutaneous squamous cell carcinoma (SCC) of the hands and fingers are sometimes locally aggressive; with higher rates of regional metastasis than other cutaneous SCC, although distant metastasis is rare.
-
Article
Open AccessClinical significance of MRI/18F-FDG PET fusion imaging of the spinal cord in patients with cervical compressive myelopathy
18F-FDG PET is used to investigate the metabolic activity of neural tissue. MRI is used to visualize morphological changes, but the relationship between intramedullary signal changes and clinic...
-
Article
Open AccessRetroperitoneal hematoma with bone resorption around the acetabular component after total hip arthroplasty: a case report and review of the literature
Vascular complications related to cup-fixating screws penetrating the medial acetabular wall during total hip arthroplasty are not uncommon but rarely are associated with serious adverse events in the late pos...
-
Article
Anteroposterior and varus–valgus laxity of the knee increase after stair climbing in patients with mild osteoarthritis
The aim of this study was to measure exercise-induced changes in knee joint laxity in patients with knee osteoarthritis (OA). The study subjects were 46 female patients with OA and 22 age- and sex-matched norm...
-
Article
Open AccessApoptosis of neurons and oligodendrocytes in the spinal cord of spinal hyperostotic mouse (twy/twy): possible pathomechanism of human cervical compressive myelopathy
Cervical compressive myelopathy is the most serious complication of cervical spondylosis or ossification of the posterior longitudinal ligament (OPLL) and the most frequent cause of spinal cord dysfunction. Th...
-
Article
Open AccessBlockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice
Recent in vivo and in vitro studies in non-neuronal and neuronal tissues have shown that different pathways of macrophage activation result in cells with different properties. Interleukin (IL)-6 triggers the clas...
