16 Result(s)

Article

The effectiveness of relugolix compared with leuprorelin for preoperative therapy before laparoscopic myomectomy in premenopausal women, diagnosed with uterine fibroids: protocol for a randomized controlled study (MyLacR study)

The oral gonadotropin-releasing hormone antagonist relugolix, which temporarily stops menstruation, is used to treat heavy menstrual bleeding, pelvic pressure, and low back pain in women with uterine fibroids....

Mari Kitade, Jun Kumakiri, Hiroyuki Kobori, Keisuke Murakami in Trials (2024)

Article

Melatonin in chronic kidney disease: a promising chronotherapy targeting the intrarenal renin–angiotensin system

Asadur Rahman, Arif Ul Hasan, Hiroyuki Kobori in Hypertension Research (2019)

Article

Independent regulation of renin–angiotensin–aldosterone system in the kidney

Renin–angiotensin–aldosterone system (RAAS) plays important roles in regulating renal hemodynamics and functions, as well as in the pathophysiology of hypertension and renal disease. In the kidney, angiotensin...

Akira Nishiyama, Hiroyuki Kobori in Clinical and Experimental Nephrology (2018)

Article

Intrarenal renin-angiotensin system activation in end-stage renal disease

Maki Urushihara, Hiroyuki Kobori in Hypertension Research (2017)

Article

Role of the renal sympathetic nerve in renal glucose metabolism during the development of type 2 diabetes in rats

Recent clinical studies have shown that renal sympathetic denervation (RDX) improves glucose metabolism in patients with resistant hypertension. We aimed to elucidate the potential contribution of the renal sy...

Kazi Rafiq, Yoshihide Fujisawa, Shamshad J. Sherajee, Asadur Rahman… in Diabetologia (2015)

Article

Effect of dipeptidyl peptidase-4 inhibition on circadian blood pressure during the development of salt-dependent hypertension in rats

A growing body of evidence has indicated that dipeptidyl peptidase-4 (DPP-4) inhibitors have antihypertensive effects. Here, we aim to examine the effect of vildagliptin, a DPP-4-specific inhibitor, on blood p...

Abu Sufiun, Kazi Rafiq, Yoshihide Fujisawa, Asadur Rahman… in Hypertension Research (2015)

Article

(Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma

Although Wnt/β-catenin signaling is known to be aberrantly activated in PDAC, mutations of CTNNB1, APC or other pathway components are rare in this tumor type, suggesting alternative mechanisms for Wnt/β-catenin ...

Yuki Shibayama, Takayuki Fujimori, Genevieve Nguyen, Takuo Hirose… in Scientific Reports (2015)

Article

Serum soluble (pro)renin receptor levels in patients with essential hypertension

The (pro)renin receptor ((P)RR) is expressed in several tissues including kidney, heart and brain, and is thought to regulate the tissue renin–angiotensin system (RAS) through the non-proteolytic activation of...

Satoshi Morimoto, Takashi Ando, Michita Niiyama, Yasufumi Seki… in Hypertension Research (2014)

Article

Liver-specific angiotensinogen suppression: an old yet novel target for blood pressure control through RAS inhibition?

Kento Kitada, Hiroyuki Kobori, Akira Nishiyama in Hypertension Research (2014)

Article

High sodium augments angiotensin II-induced vascular smooth muscle cell proliferation through the ERK 1/2-dependent pathway

Angiotensin II (Ang II)-induced vascular injury is exacerbated by high-salt diets. This study examined the effects of high-sodium level on Ang II-induced cell proliferation in rat vascular smooth muscle cells ...

Gang Liu, Hirofumi Hitomi, Asadur Rahman, Daisuke Nakano… in Hypertension Research (2014)

Article

The angiotensin II type 1 receptor blocker olmesartan preferentially improves nocturnal hypertension and proteinuria in chronic kidney disease

Accumulated evidence suggests that an altered ambulatory blood pressure (BP) profile, particularly elevated nighttime BP, reflects target organ injury and is a better predictor of further cardiorenal risk than...

Mai Yanagi, Kouichi Tamura, Tetsuya Fujikawa, Hiromichi Wakui… in Hypertension Research (2013)

Article

Regulation of a novel angiotensin II precursor, proangiotensin-12, in the tissues by blockade of the renin–angiotensin system

Ryousuke Satou, Hiroyuki Kobori in Hypertension Research (2012)

Article

Rho-kinase/nuclear factor-κβ/angiotensinogen axis in angiotensin II-induced renal injury

Hiroyuki Kobori, Yuri Ozawa, Omar W Acres, Kayoko Miyata… in Hypertension Research (2011)

Article

Glomerular angiotensinogen is induced in mesangial cells in diabetic rats via reactive oxygen species—ERK/JNK pathways

Whereas intra-renal angiotensinogen is predominantly localized in proximal tubular cells under basal conditions, it has been previously reported that angiotensinogen expression is induced in glomeruli under pa...

Naro Ohashi, Maki Urushihara, Ryousuke Satou, Hiroyuki Kobori in Hypertension Research (2010)

Article

Systemic candesartan reduces brain angiotensin II via downregulation of brain renin–angiotensin system

The renin–angiotensin system has an important function in the regulation of blood pressure as well as in pathophysiological processes in the central nervous system. We examined the effects of the angiotensin r...

Nicolas Pelisch, Naohisa Hosomi, Masaki Ueno, Hisashi Masugata… in Hypertension Research (2010)

Article

Glomerular angiotensinogen protein is enhanced in pediatric IgA nephropathy

Enhanced intrarenal renin-angiotensin system (RAS) is implicated in the development and progression of renal injury. To investigate whether angiotensinogen (AGT) expression is involved in glomerular RAS activi...

Masanori Takamatsu, Maki Urushihara, Shuji Kondo, Maki Shimizu… in Pediatric Nephrology (2008)