12 Result(s)

Article

Melatonin in chronic kidney disease: a promising chronotherapy targeting the intrarenal renin–angiotensin system

Asadur Rahman, Arif Ul Hasan, Hiroyuki Kobori in Hypertension Research (2019)

Article

Intrarenal renin-angiotensin system activation in end-stage renal disease

Maki Urushihara, Hiroyuki Kobori in Hypertension Research (2017)

Article

Effect of dipeptidyl peptidase-4 inhibition on circadian blood pressure during the development of salt-dependent hypertension in rats

A growing body of evidence has indicated that dipeptidyl peptidase-4 (DPP-4) inhibitors have antihypertensive effects. Here, we aim to examine the effect of vildagliptin, a DPP-4-specific inhibitor, on blood p...

Abu Sufiun, Kazi Rafiq, Yoshihide Fujisawa, Asadur Rahman… in Hypertension Research (2015)

Article

Serum soluble (pro)renin receptor levels in patients with essential hypertension

The (pro)renin receptor ((P)RR) is expressed in several tissues including kidney, heart and brain, and is thought to regulate the tissue renin–angiotensin system (RAS) through the non-proteolytic activation of...

Satoshi Morimoto, Takashi Ando, Michita Niiyama, Yasufumi Seki… in Hypertension Research (2014)

Article

Liver-specific angiotensinogen suppression: an old yet novel target for blood pressure control through RAS inhibition?

Kento Kitada, Hiroyuki Kobori, Akira Nishiyama in Hypertension Research (2014)

Article

High sodium augments angiotensin II-induced vascular smooth muscle cell proliferation through the ERK 1/2-dependent pathway

Angiotensin II (Ang II)-induced vascular injury is exacerbated by high-salt diets. This study examined the effects of high-sodium level on Ang II-induced cell proliferation in rat vascular smooth muscle cells ...

Gang Liu, Hirofumi Hitomi, Asadur Rahman, Daisuke Nakano… in Hypertension Research (2014)

Article

The angiotensin II type 1 receptor blocker olmesartan preferentially improves nocturnal hypertension and proteinuria in chronic kidney disease

Accumulated evidence suggests that an altered ambulatory blood pressure (BP) profile, particularly elevated nighttime BP, reflects target organ injury and is a better predictor of further cardiorenal risk than...

Mai Yanagi, Kouichi Tamura, Tetsuya Fujikawa, Hiromichi Wakui… in Hypertension Research (2013)

Article

Regulation of a novel angiotensin II precursor, proangiotensin-12, in the tissues by blockade of the renin–angiotensin system

Ryousuke Satou, Hiroyuki Kobori in Hypertension Research (2012)

Article

Rho-kinase/nuclear factor-κβ/angiotensinogen axis in angiotensin II-induced renal injury

Hiroyuki Kobori, Yuri Ozawa, Omar W Acres, Kayoko Miyata… in Hypertension Research (2011)

Article

Glomerular angiotensinogen is induced in mesangial cells in diabetic rats via reactive oxygen species—ERK/JNK pathways

Whereas intra-renal angiotensinogen is predominantly localized in proximal tubular cells under basal conditions, it has been previously reported that angiotensinogen expression is induced in glomeruli under pa...

Naro Ohashi, Maki Urushihara, Ryousuke Satou, Hiroyuki Kobori in Hypertension Research (2010)

Article

Systemic candesartan reduces brain angiotensin II via downregulation of brain renin–angiotensin system

The renin–angiotensin system has an important function in the regulation of blood pressure as well as in pathophysiological processes in the central nervous system. We examined the effects of the angiotensin r...

Nicolas Pelisch, Naohisa Hosomi, Masaki Ueno, Hisashi Masugata… in Hypertension Research (2010)