-
Article
Epiglottitis-Like Symptoms of COVID-19 in the Omicron Wave
-
Article
Open AccessGenetic factors associated with response to as-needed aflibercept therapy for typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
In the present study, we investigated the association between susceptible genetic variants to age-related macular degeneration (AMD) and response to as-needed intravitreal aflibercept injection (IAI) therapy f...
-
Article
Clinical characteristics of cuticular drusen in the Japanese population
To investigate the clinical characteristics of eyes with cuticular drusen in Japanese individuals, while paying special attention to large colloid drusen (LCD).
-
Article
Pseudodrusen pattern and development of late age-related macular degeneration in the fellow eye of the unilateral case
To investigate whether the development of late age-related macular degeneration (AMD) in fellow eyes with pseudodrusen is associated with the pseudodrusen pattern in patients with unilateral exudative AMD.
-
Article
Open AccessClinical and genetic characteristics of pachydrusen in patients with exudative age-related macular degeneration
We investigated the clinical and genetic characteristics of patients with unilateral exudative age-related macular degeneration (AMD), including typical AMD, polypoidal choroidal vasculopathy, and retinal angi...
-
Article
Mechanisms of vision loss in eyes with macular edema associated with retinal vein occlusion
Anti-vascular endothelial growth factor agents reduce macular edema and improve vision in eyes with macular edema associated with retinal vein occlusion (RVO), including branch RVO (BRVO) and central RVO. Howe...
-
Article
Reduced light sensitivity due to impaired retinal perfusion in branch retinal vein occlusion
To study the reduction in light sensitivity in areas where impaired retinal perfusion was established by fluorescein angiogram (FA) in eyes with branch retinal vein occlusion (BRVO) that recovered from retinal...
-
Article
AREDS simplified severity scale as a predictive factor for response to aflibercept therapy for typical neovascular age-related macular degeneration
To investigate whether the severity of the condition in the untreated fellow eye is a predictive factor for the response to intravitreal aflibercept injection (IAI) for exudative age-related macular degenerati...
-
Article
Open AccessComparison of two-year outcomes after photodynamic therapy with ranibizumab or aflibercept for polypoidal choroidal vasculopathy
Photodynamic therapy (PDT) combined with intravitreal anti-vascular endothelial growth factor (VEGF) agents is currently the first-line treatment for polypoidal choroidal vasculopathy (PCV), along with anti-VE...
-
Article
Open AccessA prospective multicenter study on genome wide associations to ranibizumab treatment outcome for age-related macular degeneration
We conducted a genome-wide association study (GWAS) on the outcome of anti-VEGF treatment for exudative age-related macular degeneration (AMD) in a prospective cohort. Four hundred and sixty-one treatment-naïv...
-
Article
Prevalence and characteristics of pseudodrusen subtypes in advanced age-related macular degeneration
The purpose of our study was to investigate the clinical and genetic characteristics of pseudodrusen subtypes and their incidence in advanced age-related macular degeneration (AMD).
-
Article
Open AccessIncidence and risk factors of retreatment after three-monthly aflibercept therapy for exudative age-related macular degeneration
Though anti-vascular endothelial growth factor therapy has become the standard treatment for exudative age-related macular degeneration (AMD), retreatment after the initial loading injection is inevitable in m...
-
Article
Comparison of initial treatment between 3-monthly intravitreal aflibercept monotherapy and combined photodynamic therapy with single intravitreal aflibercept for polypoidal choroidal vasculopathy
To compare the efficacy of two different initial treatment modalities on visual outcome, need for retreatment, and angiographic improvement during 12-month follow-up for polypoidal choroidal vasculopathy (PCV).
-
Article
Retreatment of polypoidal choroidal vasculopathy after photodynamic therapy combined with intravitreal ranibizumab
To investigate the incidence, risk factors and effect on visual improvement of retreatment within 60 months after initial photodynamic therapy (PDT) combined with intravitreal ranibizumab (IVR) in eyes with tr...
-
Article
A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy
Zhenglin Yang and colleagues use whole-exome sequencing to identify a rare variant in the FGD6 gene that is associated with the polypoidal choroidal vasculopathy subtype of wet age-related macular degeneration. T...
-
Article
Correction: Corrigendum: New loci and coding variants confer risk for age-related macular degeneration in East Asians
Nature Communications 6: Article number: 6063 (2015); Published 28 January 2015; Updated 30 March 2015. The financial support for this Article was not fully acknowledged. The Acknowledgements should have inclu...
-
Article
Open AccessNew loci and coding variants confer risk for age-related macular degeneration in East Asians
Age-related macular degeneration (AMD) is a major cause of blindness, but presents differently in Europeans and Asians. Here, we perform a genome-wide and exome-wide association study on 2,119 patients with ex...
-
Article
Genetic and clinical factors associated with reticular pseudodrusen in exudative age-related macular degeneration
Reticular pseudodrusen (RPD) is considered to be a distinct entity from soft drusen and a risk factor for age-related macular degeneration (AMD). In the present study, we investigate the genetic and clinical f...
-
Article
Visual loss and perimetric sensitivity in eyes with retinitis pigmentosa
To investigate the various perimetric parameters that best predict reduction of best-corrected visual acuity (BCVA) to worse than 0.5 in the near future in eyes with retinitis pigmentosa (RP).
-
Article
Foveal sensitivity and visual acuity in macular thickening disorders
To study the relationship between foveal sensitivity and visual acuity in eyes with macular disorders exhibiting macular thickening.
