15 Result(s)

Article

Genome-wide copy number variation analysis of hepatitis B infection in a Japanese population

Genome-wide association studies have been performed to identify common genetic variants associated with hepatitis B (HB). However, little is known about copy number variations (CNVs) in HB. In this study, we p...

Masataka Kikuchi, Kaori Kobayashi, Nao Nishida, Hiromi Sawai… in Human Genome Variation (2021)

Article

Importance of HBsAg recognition by HLA molecules as revealed by responsiveness to different hepatitis B vaccines

Hepatitis B (HB) vaccines (Heptavax-II and Bimmugen) designed based on HBV genotypes A and C are mainly used for vaccination against HB in Japan. To determine whether there are differences in the genetic backg...

Nao Nishida, Masaya Sugiyama, Jun Ohashi, Yosuke Kawai… in Scientific Reports (2021)

Article

The association of integration patterns of human papilloma virus and single nucleotide polymorphisms on immune- or DNA repair-related genes in cervical cancer patients

The present study investigated the association between single nucleotide polymorphisms (SNPs) in immune- or DNA repair-related genes and the integration pattern of human papillomavirus (HPV), a promising progn...

Jungnam Joo, Yosuke Omae, Yuki Hitomi, Boram Park, Hye-** Shin… in Scientific Reports (2019)

Article

Analysis of whole Y-chromosome sequences reveals the Japanese population history in the Jomon period

The Jomon and the Yayoi are considered to be the two major ancestral populations of the modern mainland Japanese. The Jomon people, who inhabited mainland Japan, admixed with Yayoi immigrants from the Asian co...

Yusuke Watanabe, Izumi Naka, Seik-Soon Khor, Hiromi Sawai… in Scientific Reports (2019)

Article

Identification of a two-SNP PLA2R1 Haplotype and HLA-DRB1 Alleles as Primary Risk Associations in Idiopathic Membranous Nephropathy

The associations of single nucleotide polymorphisms (SNPs) in PLA2R1 and HLA-DQA1, as well as HLA-DRB1*15:01-DQB1*06:02 haplotype with idiopathic membranous nephropathy (IMN) is well known. However, the primary a...

Khun Zaw Latt, Kenjiro Honda, Myo Thiri, Yuki Hitomi, Yosuke Omae… in Scientific Reports (2018)

Article

Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma

We have performed a genome-wide association study (GWAS) including 473 Japanese HBV (hepatitis B virus)-positive HCC (hepatocellular carcinoma) patients and 516 HBV carriers including chronic hepatitis and asy...

Hiromi Sawai, Nao Nishida, Seik-Soon Khor, Masao Honda… in Scientific Reports (2018)

Article

7th Drug hypersensitivity meeting: part two

Poster walk 11: miscellaneous drug hypersensitivity 2 (P92–P94, P96–P101)

Javier Dionicio Elera, Cosmin Boteanu… in Clinical and Translational Allergy (2016)

Article

Understanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genoty**-based association analysis

Associations of variants located in the HLA class II region with chronic hepatitis B (CHB) infection have been identified in Asian populations. Here, HLA imputation method was applied to determine HLA alleles usi...

Nao Nishida, Jun Ohashi, Seik-Soon Khor, Masaya Sugiyama… in Scientific Reports (2016)

Article

HLA-A*02:06 and PTGER3 polymorphism exert additive effects in cold medicine-related Stevens–Johnson syndrome with severe ocular complications

We previously reported that PTGER3 (prostaglandin E receptor 3 (subtype EP3)) single-nucleotide polymorphisms (SNPs) were associated with Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with sever...

Mayumi Ueta, Katsushi Tokunaga, Chie Sotozono, Hiromi Sawai… in Human Genome Variation (2015)

Article

Strong association between hla-a*02:06 and acetaminophen-related stevens-johnson syndrome with severe mucosal involvements in the Japanese

Mayumi Ueta, Chie Sotozono, Hiromi Sawai… in Clinical and Translational Allergy (2014)

Article

Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement

Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroida...

Mayumi Ueta, Nahoko Kaniwa, Chie Sotozono, Katsushi Tokunaga… in Scientific Reports (2014)

Article

No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations

A recent genome-wide association study (GWAS) using chronic HBV (hepatitis B virus) carriers with and without hepatocellular carcinoma (HCC) in five independent Chinese populations found that one SNP (rs174019...

Hiromi Sawai, Nao Nishida, Hamdi Mbarek, Koichi Matsuda… in BMC Medical Genetics (2012)

Article

Lineage-specific positive selection at the merozoite surface protein 1 (msp1) locus of Plasmodium vivax and related simian malaria parasites

The 200 kDa merozoite surface protein 1 (MSP-1) of malaria parasites, a strong vaccine candidate, plays a key role during erythrocyte invasion and is a target of host protective immune response. Plasmodium vivax,...

Hiromi Sawai, Hiroto Otani, Nobuko Arisue, Nirianne Palacpac… in BMC Evolutionary Biology (2010)