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Article
Open AccessRecombinant antithrombin attenuates acute kidney injury associated with rhabdomyolysis: an in vivo animal study
Rhabdomyolysis is characterized by the destruction and necrosis of skeletal muscle tissue, resulting in acute kidney injury (AKI). Recombinant antithrombin (rAT) has DNA repair and vascular endothelial-protect...
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Mouse Brain Tissue Preparation for Scanning Electron Microscopy
Scanning electron microscopy (SEM) is used to observe the surface structure of an object by irradiating an electron beam onto the sample and detecting the reflected and emitted electrons. Because of its large ...
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Article
Open AccessDelayed diagnosis of Lemierre’s syndrome in a patient with severe coronavirus disease 2019: importance of comprehensive oral and neck examination – a case report
Given the widespread prevalence of the coronavirus disease 2019 (COVID-19), oral and neck examinations tend to be avoided in patients with suspected or confirmed COVID-19. This might delay the diagnosis of con...
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Article
Open AccessInvestigation of the relationship between intradialytic hypotension during hemodialysis and serum syndecan-1 concentration
Intradialytic hypotension and arrhythmias are complications of hemodialysis. They are associated with decreased intravascular volume due to reduced ultrafiltration volume, cardiac function, and arterial tone. ...
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Article
Open AccessAtypical drug-induced hypersensitivity syndrome with multiple organ failure rescued by combined acute blood purification therapy: a case report
Drug-induced hypersensitivity syndrome (DIHS), including Stevens-Johnson syndrome (SJS), is a severe rash that often develops 2–6 weeks after the intake of the causative drug; however, its diagnosis is sometim...
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Article
Open AccessSpinal injury with spinal ankylosing disorders as a primary cause of death: report of two cases
Spinal ankylosing disorders (SADs) refer to a group of conditions resulting in spontaneous or postsurgical ossification and fusion of the spinal segments. The spine becomes increasingly susceptible to injury o...
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Article
Open AccessHypergranulation over a meshed split-thickness skin graft, a complication of negative-pressure wound therapy: a case report
We present a case of a rare complication of negative-pressure wound therapy (NPWT) wherein there was fixation of a meshed split-thickness skin graft (STSG), suspected as a failure by hypergranulation. However,...
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Article
Open AccessComplex poisoning mainly with benzyl alcohol complicated by paralytic ileus: a case report
Benzyl alcohol is used as strip** agent in paints and other applications, and benzyl alcohol poisoning is indicated by symptoms, such as impaired consciousness, respiratory depression, hypotension, metabolic...
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Article
Open AccessLeriche syndrome diagnosed due to polytrauma: a case report
Leriche syndrome is caused by atherosclerosis and is often characterized by symptoms such as intermittent claudication and numbness and coldness of the lower limbs. Its exact prevalence and incidence are unkno...
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Article
Open AccessPoint of tangency between coronavirus disease and endothelial injury
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Article
Open AccessEndothelial cell-specific reduction of heparan sulfate suppresses glioma growth in mice
Heparan sulfate (HS) is one of the factors that has been suggested to be associated with angiogenesis and invasion of glioblastoma (GBM), an aggressive and fast-growing brain tumor. However, it remains unclear...
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Article
Open AccessEffect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study
To evaluate the effect of cryoprecipitate (CRYO) transfusion in women referred for postpartum hemorrhage (PPH). This retrospective cohort study included patients with primary PPH referred to Gifu University Ho...
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Article
Open AccessPostmortem diagnosis of pulmonary tumor thrombotic microangiopathy with rapid exacerbation in a patient with gastric cancer: a case report
Pulmonary tumor thrombotic microangiopathy (PTTM) is a condition that involves the development of pulmonary hypertension due to the presence of microscopic tumor emboli of the peripheral pulmonary arteries. He...
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Article
Open AccessValidity and risk factor analysis for helicopter emergency medical services in Japan: a pilot study
Some emergency departments use triage scales, such as the Canadian Triage and Acuity Scale and Japan Urgent Stroke Triage Score, to detect life-threatening situations. However, these protocols have not been us...
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Article
Open AccessSerum syndecan-1 reflects organ dysfunction in critically ill patients
Syndecan-1 (SDC-1) is found in the endothelial glycocalyx and shed into the blood during systemic inflammatory conditions. We investigated organ dysfunction associated with changing serum SDC-1 levels for earl...
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Article
Open AccessSevere heat stroke complicated by multiple cerebral infarctions: a case report
Heat-related illnesses include symptoms such as heat syncope/cramps, heat exhaustion, and life-threatening heat stroke. Usually, a heat stroke causes cerebellar ataxia, cognitive impairment, dysphagia, and aph...
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Article
Open AccessPossible involvement of Syndecan-1 in the state of COVID-19 related to endothelial injury
The coronavirus infection 2019 (COVID-19) is associated with microvascular endothelial injury. Here, we report that syndecan-1, a component of endothelial glycocalyx, may reflect the disease state of COVID-19 ...
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Article
Open AccessMultiple trauma including pelvic fracture with multiple arterial embolization: an autopsy case report
Pelvic fracture with high energy trauma has a high mortality rate, especially in men. In addition, severe multiple trauma, major hemorrhage, and administration of red blood cells predict mortality in elderly p...
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Article
Open AccessHerpes zoster and meningitis in an immunocompetent child: a case report
Development of neurological complications of varicella zoster virus reactivation is relatively uncommon, particularly in an immunocompetent child.
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Article
Open AccessBrain-Specific Ultrastructure of Capillary Endothelial Glycocalyx and Its Possible Contribution for Blood Brain Barrier
Endothelial glycocalyx coats healthy vascular endothelium and plays an important role in vascular homeostasis. Although cerebral capillaries are categorized as continuous, as are those in the heart and lung, t...
