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Article
Open AccessMicrocirculatory disturbance in acute liver injury is triggered by IFNγ-CD40 axis
Acute liver failure (ALF) is a life-threatening disorder that progresses from self-limiting acute liver injury (ALI). Microcirculatory disturbance characterized by sinusoidal hypercoagulation and subsequent ma...
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Article
Open AccessMyeloid cell-specific ablation of Runx2 gene exacerbates post-infarct cardiac remodeling
Runt-related transcription factor 2 (Runx2), a regulator of osteoblast differentiation, is pathologically involved in vascular calcification; however, the significance of Runx2 in cardiac homeostasis remains u...
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Article
Open AccessSLPI is a critical mediator that controls PTH-induced bone formation
Osteoclastic bone resorption and osteoblastic bone formation/replenishment are closely coupled in bone metabolism. Anabolic parathyroid hormone (PTH), which is commonly used for treating osteoporosis, shifts t...
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Article
Open AccessIn vivo dynamic analysis of BMP-2-induced ectopic bone formation
Bone morphogenetic protein (BMP)-2 plays a central role in bone-tissue engineering because of its potent bone-induction ability. However, the process of BMP-induced bone formation in vivo remains poorly elucidate...
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Article
Open AccessBovine sperm selection procedure prior to cryopreservation for improvement of post-thawed semen quality and fertility
The application of cryopreservation and artificial insemination technology have contributed to the advancement of animal reproduction. However, a substantial proportion of spermatozoa undergoes alterations and...
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Article
Open AccessRoles of Enhancer RNAs in RANKL-induced Osteoclast Differentiation Identified by Genome-wide Cap-analysis of Gene Expression using CRISPR/Cas9
Bidirectional transcription has been proposed to play a role associated with enhancer activity. Transcripts called enhancer RNAs (eRNAs) play important roles in gene regulation; however, their roles in osteocl...
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Article
Open AccessAutomated transition analysis of activated gene regulation during diauxic nutrient shift in Escherichia coli and adipocyte differentiation in mouse cells
Comprehensively understanding the dynamics of biological systems is among the biggest current challenges in biology and medicine. To acquire this understanding, researchers have measured the time-series expres...
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Article
Open AccessDirect cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
Bone homeostasis is regulated by communication between bone-forming mature osteoblasts (mOBs) and bone-resorptive mature osteoclasts (mOCs). However, the spatial–temporal relationship and mode of interaction i...
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Article
Open AccessTranscriptomic signature of the follicular somatic compartment surrounding an oocyte with high developmental competence
During antral folliculogenesis, developmental competence of prospective oocytes is regulated in large part by the follicular somatic component to prepare the oocyte for the final stage of maturation and subseq...
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Article
Open AccessDirected evolution of cell size in Escherichia coli
In bacteria, cell size affects chromosome replication, the assembly of division machinery, cell wall synthesis, membrane synthesis and ultimately growth rate. In addition, cell size can also be a target for Da...
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Inference of TFRNs (2)
This chapter introduces to a study aiming at comprehensively understanding the transcription factor regulatory networks (TFRNs) that govern the process of a cell differentiation. Here we focus on the adipocyte...
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Article
Analysis about the influence on the fetus infected with parvovirus B19 using amniotic erythropoietin and troponin-T
We tried to identify the influence on the fetus infected with parvovirus B19 (PB19) and retrospectively analyze the severity of fetal infection.
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Article
Open AccessThe effect of intravenous glucose solutions on neonatal blood glucose levels after cesarean delivery
Intravenous solutions are often administered to the mother on the day of a cesarean delivery to minimize the effect of preoperative fasting or to stabilize the hemodynamics. Different intravenous solutions con...
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Article
Open AccessMultilevel comparative analysis of the contributions of genome reduction and heat shock to the Escherichia colitranscriptome
Both large deletions in genome and heat shock stress would lead to alterations in the gene expression profile; however, whether there is any potential linkage between these disturbances to the transcriptome ha...
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Article
Open AccessAn estimation method for inference of gene regulatory net-work using Bayesian network with uniting of partial problems
Bayesian networks (BNs) have been widely used to estimate gene regulatory networks. Many BN methods have been developed to estimate networks from microarray data. However, two serious problems reduce the effec...
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Article
Open AccessPerfect Hamming code with a hash table for faster genome map**
With the advent of next-generation sequencers, the growing demands to map short DNA sequences to a genome have promoted the development of fast algorithms and tools. The tools commonly used today are based on ...
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Article
Exploration of Potential Genomic Portraits Associated with Intrahepatic Recurrence in Human Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a heterogeneous disease with recognized variability in virus infection, genetic features, and clinical outcome. To date, transcriptional profilings of HCC have been used to pr...
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Article
Mobile-bearing prosthesis did not improve mid-term clinical results of total knee arthroplasty
A prospective study was performed to compare the clinical and radiological results of mobile- and fixed-bearing total knee arthroplasty with specific attention to rotational alignment and range of motion. Sixt...
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Article
Development of an Ultra-Rapid Diagnostic Method Based on Heart-Type Fatty Acid Binding Protein Levels in the CSF of CJD Patients
Creutzfeldt-Jakob disease (CJD) is a transmissible, fatal, neurodegenerative disease in humans. Recently, various drugs have been reported to be useful in the treatment of CJD; however, for such treatments to ...
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Article
Sudden cardiac arrest during cesarean section due to epidural anaesthesia using ropivacaine: a case report
Sudden cardiac arrest occurred subsequent to epidural anaesthesia in the patient of elective cesarean section. During cardio–pulmonary resuscitation, immediate section saved the infant and the mother recovered...
