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Article
Open AccessPostmortem gene expression profiles in the habenulae of suicides: implication of endothelial dysfunction in the neurovascular system
The habenula (Hb) is an epithalamic structure that links multiple forebrain areas with the mid/hindbrain monoaminergic systems. As an anti-reward center, it has been implicated in the etiology of various neuro...
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Article
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 6...
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Article
Open AccessHighly sensitive and multiplexed one-step RT-qPCR for profiling genes involved in the circadian rhythm using microparticles
Given the growing interest in molecular diagnosis, highly extensive and selective detection of genetic targets from a very limited amount of samples is in high demand. We demonstrated the highly sensitive and ...
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Article
Open AccessPsychological characteristics and associations between living kidney transplantation recipients and biologically related or unrelated donors
Although recipients and donors in living kidney transplantation experience psychological distress—including depression and anxiety—during the pre-operative period, very few studies have evaluated the related p...
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Article
Open AccessTemporal association between zolpidem medication and the risk of suicide: A 12-year population-based, retrospective cohort study
There have been concerns about abuse and unnecessary chronic administration of zolpidem, and zolpidem’s relation to suicide risk. To investigate the temporal association of zolpidem with the risk of suicide, w...
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Article
Circadian disruption and increase of oxidative stress in male and female volunteers after bright light exposure before bed time
Circadian rhythms are patterns of behaviour, physiology, and metabolism that occur within a period of approximately 24 h. The higher risk of breast and prostate cancers among shift workers, as well as the gene...
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Comorbid Sleep and Wake Problems in Treatment-Resistant Psychiatric Conditions
Sleep and wake problems are comorbid in several psychiatric illnesses and are often important factors in treatment resistance. They are often experienced in clinical situations. For example, it is common to co...
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Chapter
Sleep and Sleep Disorders in Depression
Disturbances of the sleep-wake cycle are very common in depression and serve as a sensitive biological marker of brain function. Insomnia and hypersomnia not only are some of the main symptoms of depression bu...
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Article
Open AccessCorrelation of occupational stress with depression, anxiety, and sleep in Korean dentists: cross-sectional study
This study aimed to investigate the degree of occupational stress and the clinical mental state of dentists. In addition, we investigated the correlation of occupational stress with depression, anxiety, and sl...
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Article
The quality of life of suspected obstructive sleep apnea patients is related to their subjective sleep quality rather than the apnea-hypopnea index
The relationship between the severity of the apnea-hypopnea index (AHI) and the quality of life (QOL) in patients with obstructive sleep apnea (OSA) has been inconsistent in previous studies. This study aimed ...
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Article
Open AccessDecrease in fMRI brain activation during working memory performed after slee** under 10 lux light
The aim of this study was to investigate the effect of exposure to dim light at night (dLAN) when slee** on functional brain activation during a working-memory tasks. We conducted the brain functional magnet...
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Article
Open AccessMolecular circadian rhythm shift due to bright light exposure before bedtime is related to subthreshold bipolarity
This study examined the link between circadian rhythm changes due to bright light exposure and subthreshold bipolarity. Molecular circadian rhythms, polysomnography, and actigraphy data were studied in 25 youn...
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Article
Open AccessFMR1, circadian genes and depression: suggestive associations or false discovery?
There are several indications that malfunctions of the circadian clock contribute to depression. To search for particular circadian gene polymorphisms associated with depression, diverse polymorphisms were gen...
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Article
Open AccessPER2 Variation is Associated with Diurnal Preference in a Korean Young Population
The PER2 gene has been reported to influence diurnal preference. In this study, we have attempted to characterize the associations between the PER2 gene polymorphisms and diurnal preference in a population of hea...
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Article
A Tryptophan Hydroxylase 2 Gene Polymorphism is Associated with Panic Disorder
Panic disorder (PD) is a complex and heterogeneous psychiatric condition. Dysfunction within the serotonergic system has been hypothesized to play an important role in PD. The novel brain-specific serotonin sy...
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Psychosocial and Genetic Susceptibility to Posttraumatic Stress Disorder
