20 Result(s)
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Chapter
Accessory cell function of human endothelial cells: presentation of antigen to T cells
Recognition of antigen by either in vitro or in vivo primed human T cells requires the participation of some type of Ia positive antigen-presenting cells (for ref. see 1). In rodent and human systems, peripheral ...
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Article
Human interleukin-2 activated cytotoxic cells kill autologous glioma cells in vitro
We have cultured peripheral blood lymphocytes (PBL) from glioblastoma patients in recombinant interleukin-2 (IL-2) containing medium for a period of 5 days. The cytotoxicity of these cells was tested on 51Cr-labe...
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Article
Intra-arterial BCNU in the treatment of recurrent medulloblastoma
Two patients with recurrent medulloblastomas were treated with combined oral and intra-venous chemotherapy followed by intra-arterial BCNU. The 7 days course of oral and intra-venous chemotherapy consisted of ...
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Article
High incidence of serious side effects of high-dose dexamethasone treatment in patients with epidural spinal cord compression
Twenty-eight consecutive patients were given high-dose dexamethasone (96 mg i.v. loading dose, decreasing doses to zero in 14 days) and radiotherapy for epidural spinal cord compression due to malignant diseas...
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Article
Pre-radiation chemotherapy in glioma patients with poor prognostic factors
Nineteen patients in an age group from 56–67 years (mean age 62,5 years) with histologically verified glioblastoma multiforme were treated with chemotherapy consisting of two cycles of oral CCNU, intravenous v...
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Article
Combined intra-arterial chemotherapy followed by radiation in astrocytomas
Seventy-five patients harboring astrocytomas received 4 cycles of infra-ophtalmic carotid injections of BCNU, combined with vincristine intravenously and procarbazine orally. All of the patients thereafter, re...
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Article
Prognostic significance of CT contrast enhancement within histological subgroups of intracranial glioma
We report the prognostic significance of tumor CT contrast enhancement within histological subgroups in 831 consecutive adult glioma patients of high-grade (n=516) and low-grade (n=315) histology. In the prese...
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Article
An Indwelling Brachytherapy Balloon Catheter: Potential Use as an Intracranial Light Applicator for Photodynamic Therapy
An indwelling balloon applicator developed for postoperative intracavity afterloading brachytherapy was evaluated for photodynamic therapy (PDT). Following tumor resection, the applicator is positioned in the ...
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Article
ALA- and ALA-ester-mediated Photodynamic Therapy of Human Glioma Spheroids
The effects of photodynamic therapy (PDT) in human glioma spheroids incubated in 5-aminolevulinic acid (ALA), or ALA esters, are investigated. Spheroid survival and growth are monitored following PDT at repres...
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Article
Repetitive 5-aminolevulinic acid-mediated photodynamic therapy on human glioma spheroids
The response of human glioma spheroids to repetitive 5-aminolevulinic acid-mediated photodynamic therapy (PDT) was investigated. In all cases, light fluences were kept below toxic thresholds to simulate condit...
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Article
Enhanced cytotoxic effects of 5-aminolevulinic acid-mediated photodynamic therapy by concurrent hyperthermia in glioma spheroids
During photodynamic therapy (PDT) both normal and pathological brain tissue, in close proximity to the light source, can experience significant temperature increases. The purpose of this study was to investiga...
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Article
Motexafin gadolinium enhances the efficacy of aminolevulinic acid mediated-photodynamic therapy in human glioma spheroids
Photodynamic therapy (PDT) has been investigated as a postoperative treatment in patients with high grade gliomas. The purpose of this in vitro investigation was to determine whether motexafin gadolinium (MGd)...
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Article
Targeted delivery of bleomycin to the brain using photo-chemical internalization of Clostridium perfringens epsilon prototoxin
Cells infiltrating into normal brain from malignant brain tumors are protected by the blood brain barrier (BBB) which prevents the delivery and limits the effects of anti-tumor agents. We have evaluated the ab...
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Article
Open AccessPhotothermal treatment of glioma; an in vitro study of macrophage-mediated delivery of gold nanoshells
One of the major factors that limits the treatment effectiveness for gliomas is the presence of the blood–brain barrier (BBB) which protects infiltrating glioma cells from the effects of anti-cancer agents. Ci...
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Article
Increased sensitivity of glioma cells to 5-fluorocytosine following photo-chemical internalization enhanced nonviral transfection of the cytosine deaminase suicide gene
Despite advances in surgery, chemotherapy and radiotherapy, the outcomes of patients with GBM have not significantly improved. Tumor recurrence in the resection margins occurs in more than 80 % of cases indica...
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Article
Nanoparticle-loaded macrophage-mediated photothermal therapy: potential for glioma treatment
Gold-based nanoparticles have been used in a number of therapeutic and diagnostic applications. The purpose of this study was to investigate the efficacy of gold–silica nanoshells (AuNS) in photothermal therap...
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Article
Enhancing the effects of chemotherapy by combined macrophage-mediated photothermal therapy (PTT) and photochemical internalization (PCI)
Light-based treatment modalities such as photothermal therapy (PTT) or photochemical internalization (PCI) have been well documented both experimentally and clinically to enhance the efficacy of chemotherapy. ...
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Article
Photosensitizer delivery by fibrin glue: potential for bypassing the blood-brain barrier
Fibrin glue (FG) has potential as a delivery vehicle for photosensitizer directly to the resection cavity, so it may bypass the blood-brain barrier (BBB) and increase the concentration of successfully delivere...
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Article
An improved in vitro photochemical internalization protocol for 3D spheroid cultures
Photochemical internalization (PCI) is a modified form of photodynamic therapy (PDT) that enhances the efficacy of therapeutic agents in a site and temporal specific manner in both in vitro and in vivo publica...
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Article
Open AccessFibrin glue mediated direct delivery of radiation sensitizers results in enhanced efficacy of radiation treatment
Radiation therapy (RT) plays an important role in the treatment of glioblastoma multiforme (GBM). However, inherent intrinsic resistance of tumors to radiation, coupled with the need to consider the tolerance ...
