Abstract
Recognition of antigen by either in vitro or in vivo primed human T cells requires the participation of some type of Ia positive antigen-presenting cells (for ref. see 1). In rodent and human systems, peripheral blood-derived monocyte/macrophages (MØ), Langerhans epidermal cells, and splenic dendritic cells, all of which carry Ia or Ia-like determinants have shown themselves to be effective accessory cells (2–7). In man, as well as in rodents, gene products of the major histocompatibility complex (HLA) are involved in T cell-accessory cell interaction and activation of sensitized T cells in vitro seems to require co-recognition of self MHC (HLA-D/DR) gene products on the accessory cells together with antigen (8, 9 and 10 for ref.).
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© 1984 Martinus Nijhoff Publishers, Boston
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Hirschberg, H. (1984). Accessory cell function of human endothelial cells: presentation of antigen to T cells. In: Jaffe, E.A. (eds) Biology of Endothelial Cells. Developments in Cardiovascular Medicine, vol 27. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2825-4_39
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DOI: https://doi.org/10.1007/978-1-4613-2825-4_39
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