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Article
Open AccessPlasmacytoid dendritic cells control homeostasis of megakaryopoiesis
Platelet homeostasis is essential for vascular integrity and immune defence1,2. Although the process of platelet formation by fragmenting megakaryocytes (MKs; thrombopoiesis) has been extensively studied, the cel...
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Article
Open AccessOntogeny of arterial macrophages defines their functions in homeostasis and inflammation
Arterial macrophages have different developmental origins, but the association of macrophage ontogeny with their phenotypes and functions in adulthood is still unclear. Here, we combine macrophage fate-map**...
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Article
Open AccessCathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation
Leukocyte-released antimicrobial peptides contribute to pathogen elimination and activation of the immune system. Their role in thrombosis is incompletely understood. Here we show that the cathelicidin LL-37 i...