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Article
LAMMER Kinase Governs the Expression and Cellular Localization of Gas2, a Key Regulator of Flocculation in Schizosaccharomyces pombe
It was reported that LAMMER kinase in Schizosaccharomyces pombe plays an important role in cation-dependent and galactose-specific flocculation. Analogous to other flocculating yeasts, when cell wall extracts of ...
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Article
Open AccessDifferent inhaled corticosteroid doses in triple therapy for chronic obstructive pulmonary disease: systematic review and Bayesian network meta-analysis
A systematic review and Bayesian network meta-analysis is necessary to evaluate the efficacy and safety of triple therapy with different doses of inhaled corticosteroids (ICS) in stable chronic obstructive pul...
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Article
Mannitol-1-phosphate dehydrogenase, MpdA, is required for mannitol production in vegetative cells and involved in hyphal branching, heat resistance of conidia and sexual development in Aspergillus nidulans
Aspergillus nidulans produces cleistothecia as sexual reproductive organs in a process affected by genetic and external factors. To gain a deeper insight into A. nidulans sexual development, we performed comparat...
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Article
Open AccessMutations in FAM50A suggest that Armfield XLID syndrome is a spliceosomopathy
Intellectual disability (ID) is a heterogeneous clinical entity and includes an excess of males who harbor variants on the X-chromosome (XLID). We report rare FAM50A missense variants in the original Armfield XLI...
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Article
The putative C2H2 transcription factor RocA is a novel regulator of development and secondary metabolism in Aspergillus nidulans
Multiple transcriptional regulators play important roles in the coordination of developmental processes, including asexual and sexual development, and secondary metabolism in the filamentous fungus Aspergillus ni...
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Article
Open AccessSurvival factor SvfA plays multiple roles in differentiation and is essential for completion of sexual development in Aspergillus nidulans
The first member of the velvet family of proteins, VeA, regulates sexual development and secondary metabolism in the filamentous fungus Aspergillus nidulans. In our study, through comparative proteome analysis us...
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Article
Expression of sexual genes in Aspergillus fumigatus homogeneous culture produced by vegetative mass mating
There are presently no studies on the genes for sexual development of Aspergillus fumigatus in situ using mating culture, primarily because of challenging experimental conditions that require a significantly long...
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Article
Transcriptional regulation of fksA, a β-1,3-glucan synthase gene, by the APSES protein StuA during Aspergillus nidulans development
The temporal and spatial regulation of β-1,3-glucan synthesis plays an important role in morphogenesis during fungal growth and development. Northern blot analysis showed that the transcription of fksA, the gene ...
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Article
Erratum to: Phycicoccus ochangensis sp. nov., Isolated from Soil of a Potato Cultivation Field
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Article
Phycicoccus ochangensis sp. nov., isolated from soil of a potato cultivation field
Two novel, Gram-positive, motile, coccal bacteria, strains L1b-b9T and B5a-b5, were isolated from a potato cultivation field in Ochang, Korea. These isolates grew at 10–45°C, pH 5.0–10.0, and in the presence of 8...
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Article
Effects of mutations in the WD40 domain of α-COP on its interaction with the COPI coatomer in Saccharomyces cerevisiae
Replacement of glycine 227 in the fifth WD40 motif of α-COP/Ret1p/Soo1p by charged or aromatic amino acids is responsible for the temperature-dependent osmo-sensitivity of Saccharomyces cerevisiae, while truncati...
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Article
Correction: Corrigendum: Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe
Nat. Biotechnol. 28, 617–623 (2010); published online 16 May 2010; corrected after print 7 December 2010 In the version of this article initially published, the address of one of the authors, Young-Joo Jang, w...
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Article
Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe
Genome-wide single-gene deletion libraries can be important tools for understanding the molecular workings of an organism, but have only been created for a single eukaryotic species, Saccharomyces cerevisiae. Now...
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Article
Generation of expression vectors for high-throughput functional analysis of target genes in Schizosaccharomyces pombe
An immediate challenge in the post-genomic era is to assign a biological functions to proteins unraveled by genome analysis. This report is based on studies conducted using Schizosaccharomyces pombe, a simple mod...
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Article
Paenibacillus camelliae sp. nov., isolated from fermented leaves of Camellia sinensis
A novel bacterium, strain blls-2T was isolated from Pu’er tea. The isolate was Gram-positive, endospore-forming motile rod that grew at 15∼42°C and pH 6.0∼10.2. The DNA G+C content was 48.3 mol%, the predominant ...
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Article
Conformational Analysis, Molecular Modeling, and Quantitative Structure–Activity Relationship Studies of Agents for the Inhibition of Astrocytic Chloride Transport
Molecular modeling studies were carried out on a series of 1-oxoisoindolines which are pharmacologically active as inhibitors of astrocytic chloride transport. Conformational analysis revealed that the halogen...
