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Article
Open AccessEpigenetic targets of Janus kinase inhibitors are linked to genetic risks of rheumatoid arthritis
Current strategies that target cytokines (e.g., tumor necrosis factor (TNF)-α), or signaling molecules (e.g., Janus kinase (JAK)) have advanced the management for allergies and autoimmune diseases. Nevertheles...
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Article
The effects of breast density on the benefits of mammograms with adjunctive ultrasonography in breast screening
Various efforts have been made to improve the accuracy of breast cancer screening. This study aimed to report differences in the contribution of ultrasonography to cancer screening assessments of dense and non...
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Article
Examination of age-related changes in the submandibular glands of male mice
Salivary gland hypofunction adversely affects the oral environment and daily life by causing dry mouth (xerostomia). Senescence-related atrophy of salivary gland tissues is one cause of xerostomia, and it is p...
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Article
Open AccessBundling of collagen fibrils influences osteocyte network formation during bone modeling
Osteocytes form a cellular network by gap junctions between their cell processes. This network is important since intercellular communication via the network is essential for bone metabolism. However, the fact...
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Article
Open AccessRare case of exostosin 1/exostosin 2-related membranous lupus nephritis concomitant with dual ANCA- and anti-GBM antibody-associated crescentic glomerulonephritis effectively diagnosed by mass spectrometry: a case report
Recent developments in mass spectrometry (MS) have revealed target antigens for membranous nephropathy (MN), including phospholipase A2 receptor and exostosin 1/exostosin 2 (EXT1/2). EXT1/2 are known antigens ...
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Article
A morphometric analysis of the osteocyte canaliculus using applied automatic semantic segmentation by machine learning
Osteocytes play a role as mechanosensory cells by sensing flow-induced mechanical stimuli applied on their cell processes. High-resolution imaging of osteocyte processes and the canalicular wall are necessary ...
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Article
Long-term clinical course of immunotactoid glomerulopathy complicated with diffuse large B-cell lymphoma
We report a case of immunotactoid glomerulopathy (ITG) complicated with diffuse large B-cell lymphoma (DLBCL). A 68-year-old woman presented with leg edema and was diagnosed with nephrotic syndrome (NS). Renal...
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Article
Systemic Elevation of n-3 Polyunsaturated Fatty Acids (n-3-PUFA) Is Associated with Protection against Visual, Motor, and Emotional Deficits in Mice following Closed-Head Mild Traumatic Brain Injury
Traumatic brain injury (TBI) causes neuroinflammation and neurodegeneration leading to various pathological complications such as motor and sensory (visual) deficits, cognitive impairment, and depression. N-3 ...
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Article
Effects of the prevention of medication-related osteonecrosis of the jaw by local administration of a dental pulp stem cell-conditioned medium to the rat tooth extraction socket
The onset of osteonecrosis of the jaw, which is a side effect of bisphosphonates, often develops after tooth extraction; measures for its prevention have not yet been established. While treatment with systemic...
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Article
Open AccessInitiation of peritoneal dialysis in a patient with chronic renal failure associated with tetralogy of Fallot: a case report
Tetralogy of Fallot is the most common cyanotic congenital heart disease. Patients with the condition have a high risk of develo** chronic kidney disease. Treatment of kidney disease in patients with complex...
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Chapter and Conference Paper
A Comparative Study of The Corpus for Story Creation System
In recent years, there are lots of researches to generate creations such as comics and novels by computing methods. Especially, the orders of sentences are very important for the quality of stories. Thus, the ...
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Article
An autopsy case of TAFRO syndrome with membranoproliferative glomerulonephritis-like lesions
TAFRO syndrome (thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly) is an atypical manifestation of multicentric Castleman’s disease. Although overproduction of interleukin-6, vascu...
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Article
Establishment and characterization of human gingival squamous cell carcinoma cell line NOCS-1
The NOCS-1 cell line was established from the left gingiva tumor in an 86-year-old Japanese man. Histopathological diagnosis of the original tumor was well-differentiated squamous cell carcinoma. NOCS-1 cells ...
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Article
Open AccessResected thymic large cell neuroendocrine carcinoma: report of a case
Thymic large cell neuroendocrine carcinoma (LCNEC) is extremely rare. The detailed clinical features of thymic LNCECs remain unknown.
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Article
Establishment and characterization of a squamous cell carcinoma cell line, designated hZK-1, derived from a metastatic lymph node tumor of the tongue
The hZK-1 cell line was successfully established from the metastatic foci of a lymph node of an 82-year-old Japanese woman with squamous cell carcinoma of the tongue. The pathological diagnosis of the tumor wa...
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Article
Regenerative medicine for Parkinson’s disease using differentiated nerve cells derived from human buccal fat pad stem cells
The purpose of this study was to evaluate the utility of human adipose stem cells derived from the buccal fat pad (hBFP-ASCs) for nerve regeneration. Parkinson’s disease (PD) is a neurodegenerative disorder ch...
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Article
Establishment and characterization of a clear cell carcinoma cell line, designated NOCC, derived from human ovary
A cell line, designated NOCC, was established from the ascites of a patient with clear cell adenocarcinoma of the ovary. The cell line has been grown without interruption and continuously propagated by serial ...
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Article
Effects of climatic conditions on tree-ring widths of three deciduous broad-leaved tree species at their northern distribution limit in Mont St. Hilaire, eastern Canada
This study examined the effects of climatic conditions on tree-ring widths of red oak (Quercus rubra), sugar maple (Acer saccharum) and American beech (Fagus grandifolia) at their northern distribution limit in M...
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Article
Establishment and characterization of human lingual squamous cell carcinoma cell lines designated Nialym derived from metastatic foci of lymph node, and Nialymx derived from transplanted tumor of Nialym cells
The squamous cell carcinoma cell lines Nialym was successfully established from metastatic foci of lymph nodes from a 48-year-old male Japanese patient with squamous cell carcinoma of the tongue. In addition, ...
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Article
Open AccessDichotomy in FcγRIIB deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development of autoantibodies and glomerulonephritis
The significance of a unique inhibitory Fc receptor for IgG, FcγRIIB (RIIB), in the prevention of spontaneous production of autoantibodies remains controversial, due mainly to the fact that the RIIB locus is adja...
