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  1. No Access

    Article

    Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases

    Toll-like receptor 7 (TLR7) senses microbial-derived RNA but can also potentially respond to self-derived RNA. To prevent autoimmune responses, TLR7 is thought to localize in endolysosomes. Contrary to this vi...

    Atsuo Kanno, Natsuko Tanimura, Masayuki Ishizaki, Kentaro Ohko… in Nature Communications (2015)

  2. Article

    Open Access

    Dichotomy in FcγRIIB deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development of autoantibodies and glomerulonephritis

    The significance of a unique inhibitory Fc receptor for IgG, FcγRIIB (RIIB), in the prevention of spontaneous production of autoantibodies remains controversial, due mainly to the fact that the RIIB locus is adja...

    Yasuyoshi Kanari, Akiko Sugahara–Tobinai, Haruka Takahashi, Masanori Inui… in BMC Immunology (2014)

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